Natural products of Alternaria sp., an endophytic fungus isolated from Salvadora persica from Saudi Arabia

Elgorban, Abdallah M.; Bahkali, Ali H.; Farraj, Dunia A. Al; Abdel-Wahab, Mohamed A.

doi:10.1016/j.sjbs.2018.04.010

Cited by 35 publications

(15 citation statements)

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“…The compounds found in Dendrobium, including dendrobine and related compounds, can boost human immunity besides preventing and improving metastatic cancer and have shown promising therapeutic effects on Alzheimer's disease (Nie et al, 2016). This medicinal plant has been used to prevent or treat illnesses owing to the presence of bioactive compounds in their cells and have been added to drugs since ancient times (Elgorban et al, 2019). However, dendrobine is not produced in large quantities by the D. nobile plant species because of its slow growth.…”

Section: Introductionmentioning

confidence: 99%

“…reported the possible industrial production of paclitaxel (1124.34 µg/L) under optimized fermentation conditions. A gibberellin-producing Penicillium commune strain has been recovered from the Sesamum indicum plant (Elgorban et al, 2019). Many fungal endophytes have the potential to biosynthesize numerous bioactive natural compounds that may indirectly or directly be applied as therapeutic mediators in the treatment of various diseases.…”

Section: Introductionmentioning

confidence: 99%

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New Insights into Detection of a Dendrobine Compound From a Novel Endophytic Trichoderma longibrachiatum Strain and Its Toxicity Against Phytopathogenic Bacteria

et al. 2020

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Dendrobium nobile is the only plant that could produce the natural bioactive dendrobine. No other source of dendrobine has been found to date except from D. nobile and via chemical synthesis. In this study, we aimed to examine the potential fungal endophyte isolated from D. nobile stem segments using the molecular method and to detect dendrobine compound through high-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), and liquid chromatography with tandem mass spectrometry (LC-MS/MS) and their metabolite for their antibacterial activity. The potential dendrobine producer strain was recognized as Trichoderma longibrachiatum based on molecular DNA sequencing and GenBank databases. The T. longibrachiatum MD33 produced dendrobine and other compounds in a potato dextrose medium (PDM), as confirmed by HPLC retention time peak analysis. The HPLC results revealed that T. longibrachiatum MD33 biomass showed a peak retention time of 5.28 ± 0.2 min, similar to wild D. nobile stem dendrobine (5.32 ± 0.2 min) and standard chemical reference dendrobine (5.30 ± 0.2 min), indicating the presence of dendrobine in the fungal biomass. Results of GC-MS and LC-MS analysis revealed that T. longibrachiatum MD33 produced the same molecular weight (263 in GC-MS and 264.195 in LC-MS) of dendrobine as compared with standard chemical reference dendrobine and D. nobile dendrobine. Antibacterial activity data revealed that T. longibrachiatum MD33 produced the strongest bactericidal activity against Bacillus subtilis, Bacillus mycoides, and Staphylococcus species, and the diameter of the bacterial growth inhibition zone was 12 ± 0.2, 9 ± 0.2, and 8 ± 0.2 mm, respectively. To the best of our knowledge,

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

New Insights into Detection of a Dendrobine Compound From a Novel Endophytic Trichoderma longibrachiatum Strain and Its Toxicity Against Phytopathogenic Bacteria

et al. 2020

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“…were frequently isolated more than others endophytes. Elgorban et al (2019) also showed Alternaria sp. as the prospective endophytic fungi from Salvadora persica for the production of bioactive compounds against pathogenic bacteria and fungi.…”

Section: Discussionmentioning

confidence: 96%

Endophytic fungi for biological control of whitefly and tomato leaf miner in Tanzania

Michael¹,

Nyomora²,

Mvungi³

et al. 2020

Afr. Crop Sci. J.

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Tomato whiteflies (Bemisia tabaci) and leaf miners (Tuta absoluta) are devastating pests of tomato (Lycopersicon esculentum). Pest management using broad spectrum synthetic pesticides is discouraged due to harmful effects on human health and the environment. The objective of this study was to assess the potential of endophytic fungi as bioextracts against tomato whiteflies and leaf miners, as an alternative to synthetic insecticides in Tanzania. The study was done using morphological and molecular techniques, during January 2019 to February 2020 in Arusha region in Tanzania. Three endophyte isolates from pyrethrum (Chrysanthemum cinerariifolium) and lemon grass (Cymbopogon citratus) were identified with resemblance to members of Fusarium sp and Altenaria sp, by 90 and 82 % similarity, respectively; based on phylogenetic clustering patterns and macro- and micro-morphological characteristics. Bioextracts from endophytes of lemon grass leaves (Elg1); and pyrethrum flowers (Epf1) and leaves (Epl1), showed significant repellency properties (F0.05 (df, 15) = 27.052, P = 0.0001) on whiteflies by 54, 76 and 36%, respectively. They also caused significant lethality (F0.05 (df, 11) = 59.559, P = 0.0001) of tomato leaf miner larvae and whiteflies (F0.05 (df, 11) = 53.600, P = 0.0001). The underlying effect was attributed to possession of flavonoid and total phenolics as active ingredients in the bioextracts. This was commensurate to the levels flavonoid and total phenolic contents, which were considerably more in bioextracts of lemon grass and pyrethrum flower (F0.05 (df, 8) = 10.35, P = 0.0114) and (F0.05 (df, 8) = 40.84, P = 0.0003, respectively), than in pyrethrum leaves.

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“…were restricted to stem only whereas Aspergillus sp., C. herbarum to leaves only [ 118 ]. A total of 35 isolates of endophytic fluorescent Pseudomonas were identified from the leaves, shoot, and root samples of both S. persica and S. oleoides [ 119 ] Young and old stem and 125 root segments were processed for the isolation of endophytes and resulted in forty-two fungal isolates namely, Trichoderma sp., 2 species of Alternaria , Rhizopus arrhizus and 6 sterile mycelia [ 120 ].…”

Section: Endomicrobial Diversity Of Important Medicinal Plants/genusmentioning

confidence: 99%

Bioprospecting of endophytes in medicinal plants of Thar Desert: An attractive resource for biopharmaceuticals

Yadav

Meena

2021

Biotechnology Reports

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Highlights Endophytes act as chemical synthesizers of the secondary metabolites of the host plant. Endophytic microflora has been isolated from a wide array of plants. It can serve as a good alternative source for pharmaceutically important compounds. The arid ecosystem of Thar Desert is a rich repository of ethnomedicinal plants. Role of endophytes in the synthesis of bioactive molecules used to enhance production.

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Natural products of Alternaria sp., an endophytic fungus isolated from Salvadora persica from Saudi Arabia

Cited by 35 publications

References 50 publications

New Insights into Detection of a Dendrobine Compound From a Novel Endophytic Trichoderma longibrachiatum Strain and Its Toxicity Against Phytopathogenic Bacteria

New Insights into Detection of a Dendrobine Compound From a Novel Endophytic Trichoderma longibrachiatum Strain and Its Toxicity Against Phytopathogenic Bacteria

Endophytic fungi for biological control of whitefly and tomato leaf miner in Tanzania

Bioprospecting of endophytes in medicinal plants of Thar Desert: An attractive resource for biopharmaceuticals

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