Natural Products of Actinobacteria Derived from Marine Organisms

Karuppiah, Valliappan; Sun, Wei; Li, Z.

doi:10.1016/b978-0-444-63602-7.00013-8

Cited by 16 publications

(10 citation statements)

References 125 publications

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“…Butenolides are found in a variety of natural product scaffolds and possess desirable bioactive properties . For example, linderalactone (Figure A) can protect hepatocytes from oxidative damage .…”

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confidence: 99%

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Butenolide Synthesis from Functionalized Cyclopropenones

et al. 2019

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A general method to synthesize substituted butenolides from hydroxymethylcyclopropenones is reported. Functionalized cyclopropenones undergo ring-opening reactions with catalytic amounts of phosphine, forming reactive ketene ylides. These intermediates can be trapped by pendant hydroxy groups to afford target butenolide scaffolds. The reaction proceeds efficiently in diverse solvents and with low catalyst loadings. Importantly, the cyclization is tolerant of a broad range of functional groups, yielding a variety of αand γ-substituted butenolides.

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confidence: 99%

“…B utenolides are found in a variety of natural product scaffolds and possess desirable bioactive properties. 1 For example, linderalactone (Figure 1A) can protect hepatocytes from oxidative damage. 2 Other butenolides, including (−)-incrustoporin, are potent inhibitors of pathogenic fungi.…”

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confidence: 99%

Butenolide Synthesis from Functionalized Cyclopropenones

et al. 2019

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“…Particularly interesting is that we isolated numerous novel Actinobacteria (Fig. 4b) known to be prolific producers of bioactive compounds (Karuppiah et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Accessing previously uncultured marine microbial resources by a combination of alternative cultivation methods

Jung

Liu

et al. 2021

Microbial Biotechnology

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Few microbes can grow under laboratory conditions, highlighting the fact that the majority of microbes in environment are still uncultured and untapped resources. This study used alternative cultivation methods, diffusion chambers (DC), dilution-to-extinction culture (DTE) and modified agar preparation step (PS media) to cultivate previously uncultured marine bacterial species. These methods were applied to samples from a coastal intertidal zone, and the results were compared with those from standard direct plating (SDP) cultivation. Among the strains isolated with DC, DTE and PS media methods, 28%, 48% and 33% were novel species, respectively, while the SDP method resulted in the isolation of only 9% of novel species. Most isolates were unique to the method used for their cultivation. This implies that each method is selective in its own way, which is different from SDP, thus able to access species that are difficult to obtain using conventional approaches. Comparing the diversity showed that 75 genera were recovered by the alternative methods, 2.7 times higher than that of the SDP cultivation, which constituted 45% of total diversity from culture-independent sequencing. We conclude that combining alternative cultivation methods represents a highly promising key for accessing 'microbial dark matter'.

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“…Proteases are widely employed in leather, textiles, medicines, and detergents, accounting for more than 60% of the global enzyme market [17]. Alkaline proteases are generated by a variety of microorganisms, including yeast, bacteria, fungus, and plants [18]. The process of destroying or suppressing disease-causing bacteria is referred to as antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

Production of Protease Enzyme and Antimicrobial Activities from Marine Actinobacterium of Streptomyces SP

Ananya

Sivaperumal

Anitha

et al. 2021

JPRI

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Introduction: Actinobacteria are Gram-positive bacteria that have traits of both bacteria and fungus. They are found in both terrestrial and aquatic habitats and aid in the breakdown of deceased species' organic matter. Marine actinobacteria are unusual in that they have antibacterial, anticancer, antiviral, insecticidal, and enzyme inhibitory activities. The biggest genus of Actinobacteria is Streptomyces. They create more than two-thirds of all-natural antibiotics that are therapeutically relevant (e.g. Neomycin, Cypemycin, Grisemycin, Bottromycins, and Chloramphenicol). Alkaline proteases are generated by a variety of microorganisms, including yeast, bacteria, and plants. The process of destroying or suppressing disease-causing bacteria is referred to as antimicrobial activity. This is accomplished using a variety of antimicrobial potential as well as antiviral properties. Aim: To find out the antimicrobial activity of protease enzymes produced by the Streptomyces sp of marine actinobacterium. Materials and Methods: A sediment sample was collected and marine Actinobacteria were isolated in Kuster’s Agar Medium (KUA) and were identified based on their chemotaxonomical characteristics. Results: Screening for protease was carried out to assess enzyme production and enzyme assay was carried out to assess the enzymatic activity. The effect and pH on enzyme production were observed. Then the antimicrobial potential of protease enzymes was tested against a few bacterial strains at optimum temperature and pH. Conclusion: From the above study, we conclude that the protease enzyme obtained from Streptomyces shows a potential antimicrobial (antibacterial) effect.

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Natural Products of Actinobacteria Derived from Marine Organisms

Cited by 16 publications

References 125 publications

Butenolide Synthesis from Functionalized Cyclopropenones

Butenolide Synthesis from Functionalized Cyclopropenones

Accessing previously uncultured marine microbial resources by a combination of alternative cultivation methods

Production of Protease Enzyme and Antimicrobial Activities from Marine Actinobacterium of Streptomyces SP

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