Natural products isolated from Mexican medicinal plants: Novel inhibitors of sulfotransferases, SULT1A1 and SULT2A1

Mesía-Vela, Sonia

doi:10.1078/s0944-7113(04)70070-7

Cited by 25 publications

(14 citation statements)

References 32 publications

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“…The bark of this species has been shown to contain xanthones with cancer chemopreventive properties (Ito et al, 2002). Also, potent analgesic effects were shown (da Silva et al, 2001) by the crude extracts from the leaves of this plant which contain phenolic compounds, such as hyperin (hyperoside), amentoflavone, quercetin, gallic acid and protocatechuic in polar extracts (Guimaraez et al, 1993) and coumarins in less polar extracts (Mesia-Vela et al, 2001). In addition, potent inhibition of sulfotransferase 1A1 activity was shown for the xanthones and coumarins were also tested here (Mesia-Vela et al, 2001).…”

Section: Introductionmentioning

confidence: 96%

“…Also, potent analgesic effects were shown (da Silva et al, 2001) by the crude extracts from the leaves of this plant which contain phenolic compounds, such as hyperin (hyperoside), amentoflavone, quercetin, gallic acid and protocatechuic in polar extracts (Guimaraez et al, 1993) and coumarins in less polar extracts (Mesia-Vela et al, 2001). In addition, potent inhibition of sulfotransferase 1A1 activity was shown for the xanthones and coumarins were also tested here (Mesia-Vela et al, 2001). Chemical analysis has also revealed the presence of prenylated xanthones in the bark (Sartori et al, 1999) and wood (Reyes Chilpa et al, 1997).…”

Section: Introductionmentioning

confidence: 97%

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Inhibition of gastric H+,K+-ATPase activity by flavonoids, coumarins and xanthones isolated from Mexican medicinal plants

Reyes-Chilpa

Baggio

Alavez-Solano

et al. 2006

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 97%

Inhibition of gastric H+,K+-ATPase activity by flavonoids, coumarins and xanthones isolated from Mexican medicinal plants

Reyes-Chilpa

Baggio

Alavez-Solano

et al. 2006

Journal of Ethnopharmacology

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“…(Clusiaceae) is a large tree widely distributed in Latin America, as far as from Mexico to Brazil (Mesía-Vela et al, 2001), occurring in damp and swampy ground (Botrel et al, 2006). In Brazil, it is found in large groups in the Amazon and Atlantic forests and in places that remain intermittently or permanently flooded in Brazilian Cerrado (Lorenzi, 1992).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antiulcer activity of chromanone fraction from Calophyllum brasiliesnse Camb

Lemos

Martins

Tanajura

et al. 2012

Journal of Ethnopharmacology

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“…Many endogenous and exogenous compounds inhibit the activity of sulfotransferases [16, 30–33]. Such inhibition could result from either a molecule serving solely as an inhibitor or as an alternate substrate that competes for the catalytic site of the enzyme.…”

Section: Introductionmentioning

confidence: 99%

Binding interactions of hydroxylated polychlorinated biphenyls (OHPCBs) with human hydroxysteroid sulfotransferase hSULT2A1

Ekuase

Lehmler

Robertson

et al. 2014

Chemico-Biological Interactions

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Polychlorinated biphenyls (PCBs) are persistent environmental contaminants, and exposure to PCBs and their hydroxylated metabolites (OHPCBs) has been associated with various adverse health effects. The mammalian cytosolic sulfotransferases (SULTs) catalyze the sulfation of OHPCBs, and the interaction of OHPCBs with both the SULT1 and SULT2 families of these enzymes has received attention both with respect to metabolic disposition of these molecules and the potential mechanisms for their roles in endocrine disruption. We have previously shown that OHPCBs interact with human hydroxysteroid sulfotransferase hSULT2A1, an enzyme that catalyzes the sulfation of dehydroepiandrosterone (DHEA), other alcohol-containing steroids, bile acids, and many xenobiotics. The objective of our current studies is to investigate the mechanism of inhibition of hSULT2A1 by OHPCBs by combining inhibition kinetics with determination of equilibrium binding constants and molecular modeling of potential interactions. Examination of the effects of fifteen OHPCBs on the sulfation of DHEA catalyzed by hSULT2A1 showed predominantly noncompetitive inhibition patterns. This was observed for OHPCBs that were substrates for sulfation reactions catalyzed by the enzyme as well as those that solely inhibited the sulfation of DHEA. Equilibrium binding experiments and molecular modeling studies indicated that the OHPCBs bind at the binding site for DHEA on the enzyme, and that the observed noncompetitive patterns of inhibition are consistent with binding in more than one orientation to more than one enzyme complex. These results have implications for the roles of SULTs in the toxicology of OHPCBs, while also providing molecular probes of the complexity of substrate/inhibitor interactions with hSULT2A1.

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Natural products isolated from Mexican medicinal plants: Novel inhibitors of sulfotransferases, SULT1A1 and SULT2A1

Cited by 25 publications

References 32 publications

Inhibition of gastric H+,K+-ATPase activity by flavonoids, coumarins and xanthones isolated from Mexican medicinal plants

Inhibition of gastric H+,K+-ATPase activity by flavonoids, coumarins and xanthones isolated from Mexican medicinal plants

Evaluation of antiulcer activity of chromanone fraction from Calophyllum brasiliesnse Camb

Binding interactions of hydroxylated polychlorinated biphenyls (OHPCBs) with human hydroxysteroid sulfotransferase hSULT2A1

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