Natural Products for Type II Diabetes Treatment

Plants and Natural Compounds with Antidiabetic Action

“…Nigella sativa inhibited the intestinal absorption of glucose, supporting its use as an antidiabetic compound. Other examples of plants with antidiabetic properties that were studied and confirmed by literature studies include the following: Eucalyptus globules (Ahlem et al, 2009), Phaseolus vulgaris L. (Ocho-Anin Atchibri et al, 2010), Marrubium vulgare (Elberry et al, 2011), Coriandrum sativum L. (Aissaoui et al, 2011), Swertia punicea (Tian et al, 2010), Viscum album (Ohran et al, 2005), Brassica juncea (Thirumalai et al, 2011), Salvia officinalis L. (Eidi et al, 2005), Ruta graveolens (Ahmed et al, 2010), Carissa carandas (Itankar et al, 2011), Pinus pinaster (Bedekar et al, 2010;El-Zein et al, 2011), Punica granatum (Bagri et al, 2009), and Piper retrofractum (Kim et al, 2011).…”

“…α-glucosidase is an enzyme that catalyses the decomposition of disaccharides to glucose. Any inhibitory effect from an external stimulus towards Bedekar et al, 2010;Liu et al, 2004 Piper retrofractum fruits piperidine alkaloids: piperine, pipernonaline,dehydropipernonaline 3T3-L1 adipocytes L6 myocytes Ethanol extract Kim et al, 2011 decrease in blood glucose levels upon administration of Urtica dioica extracts. According to Nistor Baldea et al (2010), Rhododendron tomentosum and Picea mariana exert inhibitory effects on the intestinal glucose absorption, both in vitro and in vivo, and decrease the expression of the Na+-dependent glucose transporter (SGLT1) and glucose transporter 2 (GLUT2) proteins in CaCo-2/15 cell lines, indicating that these plants can be useful in diabetes prevention and care.…”

Natural Products & Complementary Medicines: where are we up to?

“…Natural digestive enzyme inhibitor from plants have been widely used for the treatment of Type-II diabetes and approved by FDA like acarbose, isolated from a number of species of Actinomycetes (Al Sibae and McGuire 2009;Bedekar, Shah et al 2010). Furthermore, human clinical studies have demonstrated the effectiveness of anti-diabetic herbs such as Bidens pilosa.…”

From Nutrition to Health: The Role of Natural Products – A Review

“…Every year the number of diabetic patients is rising by 4-5% (Wagman and Nuss, 2001). Plant extract and complex microbial secondary metabolites of natural products have attracted the attention of scientific world for their potential use as drugs for the treatment of chronic diseases such as Type II diabetes (Bedekar et al, 2010). Acarbose was discovered from compounds isolated from Actinomycetes species, which are potent inhibitors of digestive enzymes such as -amylase, sucrase, and maltase.…”

“…Acarbose was discovered from compounds isolated from Actinomycetes species, which are potent inhibitors of digestive enzymes such as -amylase, sucrase, and maltase. Acarbose is the most widely used digestive enzyme inhibitor among the numerous antidiabetic drugs used for the treatment of Type-II diabetes (Bedekar et al, 2010). Maglitol which was derived from 1-deoxynorjirimycin is one of the widely used -glucosidase inhibitors used in the treatment of Type II diabetes.…”