Natural Products for the Treatment of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review

Abstract

Plants are an untapped natural resource; their secondary metabolites take part in a variety of pharmacological activities, making them an essential ingredient in the synthesis of novel medications and the source of reserve resources in this process. Hepatitis and liver cancer are two conditions that can result from non-alcoholic fatty liver disease (NAFLD). NAFLD is a condition that now affects a significant section of the global population. There is a need for preventative action on predisposing factors. Due to their effectiveness and few side effects, herbal medications are frequently utilized for the prevention and treatment of NAFLD. This review discusses the pathogenetic processes of NAFLD and the evidence brought to support the potential of botanical species and their derivatives in limiting the causes that predispose to the onset of NAFLD.

Acetylated pelargonidin-3-O-glucoside alleviates hepatocyte lipid deposition through activating the AMPK-mediated lysosome-autophagy pathway and redox state

“…), and terpenes (celastrol, boswellic acid, etc .). 6–10 One of the central regulators of cellular and organic metabolism in eukaryotes is AMP-activated protein kinase (AMPK), an evolutionarily conserved serine/threonine protein kinase that is activated when intracellular ATP levels are reduced. 11,12 AMPK is a sensor that balances the energy state of cells and plays a crucial role in regulating lipid metabolism.…”