Natural products for the treatment of stress-induced depression: Pharmacology, mechanism and traditional use

Dai, Wei; Feng, Kunmiao; Sun, Xiaolei; Xu, Lisha; Wu, Sijia; Rahman, Khalid; Jia, Dan; Han, Ting

doi:10.1016/j.jep.2021.114692

Cited by 34 publications

(21 citation statements)

References 211 publications

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“…The development of more efficient and effective antidepressants may be aided by the quest for new antidepressants based on novel methodologies. Recent studies have placed a greater emphasis on natural goods as they looked for safe and effective antidepressant medications [ 37 , 38 ]. The purpose of this study was to investigate the impact of crocin in relieving depression produced by prolonged mild stress in an animal experimental system.…”

Section: Discussionmentioning

confidence: 99%

Antidepressant Effect of Crocin in Mice with Chronic Mild Stress

et al. 2022

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This study aimed to investigate the antidepressant property of crocin (Crocetin digentiobiose ester) using a chronic mild stress (CMS)-induced depression model in experimental mice. The tail suspension test (TST) and the sucrose preference test were used to evaluate the antidepressant effect on albino mice of either sex after three weeks of CMS. The period of immobility in the TST and percentage preference for sucrose solution were recorded. By monitoring brain malondialdehyde (MDA) level, catalase (CAT) activity, and reduced glutathione (GSH) level, the antioxidant potential was assessed. Three dosages of crocin (4.84, 9.69, and 19.38 mg/kg) were evaluated. When compared to controls, animals that received crocin administration during three periods of CMS had considerably shorter immobility times during the TST. Crocin treatment also raised the percentage preference for sucrose solution in a dose-dependent manner, bringing it to parity with the conventional antidepressant, imipramine. Animals that received a high dose of crocin had a much greater spontaneous locomotor activity. Furthermore, a high dose of crocin remarkably lowered plasma corticosterone and nitrite levels brought on by CMS. Additionally, high doses of crocin given during CMS greatly enhanced reduced glutathione levels while considerably reducing the brain’s MDA and catalase activities. In conclusion, high doses of crocin may have an antidepressant effect in an animal model through several mechanisms. However, further studies should be carried out to explore the role of neurotransmitters for their antidepressant property.

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Section: Discussionmentioning

confidence: 99%

Antidepressant Effect of Crocin in Mice with Chronic Mild Stress

et al. 2022

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“…According to the literature, the effectiveness of herbal medicines for the treatment of MDD has been established (Liu et al, 2015). A growing body of evidence has verified that herbs and their active components exert promising therapeutic effects for the treatment of depressive‐like behaviors in animal models (Dai et al, 2022; Talei et al, 2021). These components exhibit antidepressant activities through anti‐inflammatory, antioxidant, and neuroprotective activities (Anjomshoa et al, 2020).…”

Section: Methodsmentioning

confidence: 99%

Targeting autophagy and neuroinflammation pathways with plant‐derived natural compounds as potential antidepressant agents

Mokhtari

2022

Phytotherapy Research

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Major depressive disorder (MDD) is a life‐threatening disease that presents several characteristics. The pathogenesis of depression still remains poorly understood. Moreover, the mechanistic interactions of natural components in treating depression to target autophagy and neuroinflammation are yet to be evaluated. This study overviewed the effects of plant‐derived natural components in regulating critical pathways, particularly neuroinflammation and autophagy, associated with depression. A list of natural components, including luteolin, apigenin, hyperforin, resveratrol, salvianolic acid b, isoliquiritin, nobiletin, andrographolide, and oridonin, have been investigated. All peer‐reviewed journal articles were searched by Scopus, MEDLINE, PubMed, Web of Science, and Google Scholar using the appropriated keywords, including depression, neuroinflammation, autophagy, plant, natural components, etc. The neuroinflammation and autophagy dysfunction are critically associated with the pathophysiology of depression. Natural components with higher efficiency and lower complications can be used for targeting neuroinflammation and autophagy. These components with different doses showed the beneficial antidepressant properties in rodents. These can modulate autophagy markers, mainly AMPK, LC3II/LC3I ratio, Beclin‐1. Moreover, they can regulate the NLRP3 inflammasome, resulting in the suppression of proinflammatory cytokines (e.g., IL‐1β and IL‐18). Future in vitro and in vivo studies are required to develop novel therapeutic approaches based on plant‐derived active components to treat MDD.

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“…Traditional Chinese medicines (TCM) are widely used in China and other countries for the treatment of mental disorders ( Dai et al, 2022 ; Wang et al, 2019b ). In China, TCM has a history of thousands of years, and is currently a significant part in the whole medical system, practiced alongside Western medicine.…”

Section: Main Research Of Pni In Chinamentioning

confidence: 99%