Natural products for orofacial nociception in pre-clinical studies: A systematic review

Oliveira, Janaíne P.; Souza, Marilia T.S.; Cercato, Luana Mendonça; Souza, Alceu; Nampo, Fernando Kenji; Camargo, E E

doi:10.1016/j.archoralbio.2020.104748

Cited by 5 publications

(2 citation statements)

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“…Evidence shows that other terpenes can reduce nociception in orofacial pain ( Oliveira et al, 2020 ). Furthermore, myrtenol has been found to have antinociceptive action in models of acetic acid-induced abdominal contortions and formalin-, glutamate- and capsaicin-induced nociception in mouse paws ( Silva et al, 2014 ).…”

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confidence: 99%

Myrtenol Reduces Orofacial Nociception and Inflammation in Mice Through p38-MAPK and Cytokine Inhibition

et al. 2022

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Orofacial pain is one of the commonest and most complex complaints in dentistry, greatly impairing life quality. Preclinical studies using monoterpenes have shown pharmacological potential to treat painful conditions, but the reports of the effects of myrtenol on orofacial pain and inflammation are scarce. The aim of this study was to evaluate the effect of myrtenol in experimental models of orofacial pain and inflammation. Orofacial nociceptive behavior and the immunoreactivity of the phosphorylated p38 (P-p38)-MAPK in trigeminal ganglia (TG) and spinal trigeminal subnucleus caudalis (STSC) were determined after the injection of formalin in the upper lip of male Swiss mice pretreated with myrtenol (12.5 and 25 mg/kg, i.p.) or vehicle. Orofacial inflammation was induced by the injection of carrageenan (CGN) in the masseter muscle of mice pretreated with myrtenol (25 and 50 mg/kg, i.p.) or its vehicle (0.02% Tween 80 in saline). Myeloperoxidase (MPO) activity and histopathological changes in the masseter muscle and interleukin (IL)-1β levels in the TG and STSC were measured. The increase in face-rubbing behavior time induced by formalin and P-p38-MAPK immunostaining in trigeminal ganglia were significantly reduced by myrtenol treatment (12.5 and 25 mg/kg). Likewise, increased MPO activity and inflammatory histological scores in masseter muscle, as well as augmented levels of IL-1β in the TG AND STSC, observed after CGN injection, were significantly decreased by myrtenol (25 and 50 mg/kg). Myrtenol has potential to treat orofacial inflammation and pain, which is partially related to IL-1β levels in the trigeminal pathway and p38-MAPK modulation in trigeminal ganglia.

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Section: Introductionmentioning

confidence: 99%

Myrtenol Reduces Orofacial Nociception and Inflammation in Mice Through p38-MAPK and Cytokine Inhibition

et al. 2022

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“…Orofacial pain primarily affects the head, face, and neck areas and is generally associated with inflammation ( Romero-Reyes and Uyanik, 2014 ). Natural products, especially terpenes are effective in modulating orofacial nociception ( Silva et al, 2016 ; Oliveira et al, 2020 ). Myrtenol in complex with β-cyclodextrin has been able to elicit anti-nociceptive behavior and cognitive enhancement in a chronic musculoskeletal pain model ( Heimfarth et al, 2020 ).…”

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Editorial: Application of plant secondary metabolites to pain neuromodulation, volume II

Singla

Guimarães²,

Zengin³

2022

Front. Pharmacol.

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Editorial on the Research Topic Application of plant secondary metabolites to pain neuromodulation, volume IIPain is an uncomfortable condition that is clinically associated with many diseases such as cancer/tumor, metabolic disorders such as diabetes, neurological diseases such as epilepsy and chronic infectious diseases, and functional disorders (Li et al., 2019;Yang, 2019;Singla et al., 2021a;Singla et al., 2021b). The neuromodulation approach has used electrical interfaces to modulate neuronal activity and has proven effective in treating various neurological disorders, including chronic pain (James et al., 2018). It has been adopted and accepted as an alternative techniques because of high attrition rates, costs as well as regulatory conditions in case of pharmacological agents (James et al., 2018). But in order to ascertain the aesthetic and appropriate usage of neurostimulation technique, organizations like "The International Neuromodulation Society (INS)" have framed the practice guidelines (Deer et al., 2014a;Deer et al., 2014b). Even for the cancer pain management, "The Indian Society for Study of Pain (ISSP)" have also prepared guidelines to cover palliative care aspects (Thota et al., 2020). As an alternative to both the synthetic pharmacological agents as well as neurostimulaory techniques, natural products have had a lot of translational potential to reach the bedside (

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Evaluation of antimicrobial and cytotoxic effects of Echinacea and Arctium extracts and Zataria essential oil

et al. 2022

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Dental caries and oral infections have become a widespread issue in the modern world. This study aimed to investigate the antibacterial, antifungal, and cytotoxicity characteristics of the extracts of Echinacea purpura, Arctium lappa, and the essential oil of Zataria multiflora as a potential herbal mouthwash. The essential oil of Z. multiflora leaves and the extracts of E. purpurea and A. lappa roots were prepared. The characterization was carried out by GC-MS and also, total phenol and flavonoid were assed for all three samples. The antimicrobial and anti-biofilm effects were evaluated against Streptococcus mutans, Streptococcus mitis, Streptococcus salivarius, Lactobacillus acidophilus, Escherichia coli, Staphylococcus aureus, and Candida albicans. The cytotoxic effect of the samples was evaluated on HEK 293 and HDFa cells by MTT test. Thymol and carvacrol contents in EO of Z. multiflora were measured at 31% and 42.2%, respectively. A. lappa had the lowest total phenolic and flavonoid value among the samples. On the other hand, the total phenolic content of Z. multiflora and the total flavonoid content of E. purpurea were the highest. The MIC values of Zataria, Arctium, and Echinacea against S. mutans were 0.011% v/v, 187.5 mg/ml, and 93.75 mg/ml, while MBC were 0.011% v/v, 375 mg/ml, and 187.5 mg/ml, respectively. The formulation showed bactericidal activity against S. mutans in the concentration of 5.86 mg/ml for Echinacea and Burdock extracts and 0.08 µl/ml for EO of Zataria. The formulation significantly affected microbial biofilm formation and induced biofilm degradation. The cell viability percentages were higher than 50% during 24 and 48 h. The formulation had a significant antimicrobial effect on cariogenic bacteria and C. albicans, with the lowest cytotoxic effects. Therefore, this formulation can be an appropriate candidate for mouthwash.

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Natural products for orofacial nociception in pre-clinical studies: A systematic review

Cited by 5 publications

References 64 publications

Myrtenol Reduces Orofacial Nociception and Inflammation in Mice Through p38-MAPK and Cytokine Inhibition

Myrtenol Reduces Orofacial Nociception and Inflammation in Mice Through p38-MAPK and Cytokine Inhibition

Editorial: Application of plant secondary metabolites to pain neuromodulation, volume II

Evaluation of antimicrobial and cytotoxic effects of Echinacea and Arctium extracts and Zataria essential oil

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