Natural Products for Cancer Therapy: A Review of Their Mechanism of Actions and Toxicity in the Past Decade

Abdalla, Yasir Osman Ali; Subramaniam, Bavani; Nyamathulla, Shaik; Shamsuddin, Noorasyikin; Arshad, Norhafiza Mohd; Mun, Kein Seong; Awang, Khalijah; Nagoor, Noor Hasima

doi:10.1155/2022/5794350

Cited by 43 publications

(29 citation statements)

References 144 publications

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“…Acting as natural modifiers of biochemical reactions, herbal medicines are promising adjunctive therapeutics. The healing properties of medicinal plants are due to a wide range of pharmacologically active ingredients: alkaloids, glycosides, saponins, and other compounds [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Extracts of Spiraea hypericifolia L. and Spiraea crenata L.: The Phenolic Profile and Biological Activities

Кайдаш

Kostikova

Udut

et al. 2022

Plants

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The comparative phytochemical analysis in this study revealed differences in the type and levels of phenolic compounds between Spiraea hypericifolia L. and Spiraea crenata L. The compounds in water–ethanol extracts of aerial parts of both species were identified by high-performance liquid chromatography as chlorogenic, gentisic, and cinnamic acids; quercetin; kaempferol; hyperoside; isoquercetin; nicotiflorin; and apigenin. In the extract of S. hypericifolia, p-coumaric acid and luteolin were also found, which were absent in the extract of S. crenata. Such compounds as avicularin, astragalin, and isorhamnetin-3-rutinoside proved to be specific to S. crenata (and were not found in the S. hypericifolia extract). The viability of liver cancer HepG2 cells and breast cancer MDA-MB-231 cells significantly decreased after cultivation with the S. crenata extract. In addition, the S. crenata extract showed higher antioxidant activity than the S. hypericifolia extract. It is most likely that these effects can be explained by the higher content of individual flavonoids in the extract of S. crenata. Thus, the extract of S. crenata holds promise for more extensive research on the mechanism of its action on tumor cells.

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Section: Introductionmentioning

confidence: 99%

Extracts of Spiraea hypericifolia L. and Spiraea crenata L.: The Phenolic Profile and Biological Activities

Кайдаш

Kostikova

Udut

et al. 2022

Plants

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show abstract

“…Recent scientific studies have shown that many food plants, medicinal plants and spices contain bioactive components such as piperine, curcumin, thymoquinone, crocin, capsaicin, polysaccharides, polyphenols, and other bioactive metabolites, which have been shown to have anticancer, anti-Inflammatory, antioxidant and immunomodulatory effects [9][10][11]. In addition.several studies reported that many natural polyphenols, which have antioxidant, anti-inflammatory and anti-diabetic properties, have beneficial effects against protein aggregates found in AD.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Polyphenols from Conyza dioscoridis (L.) ameliorate Alzheimer’s disease- like alterations through multi-targeting activities in two animal models

Gomaa

Farghaly

Makboul

et al. 2022

BMC Complement Med Ther

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Background Recent investigations suggested that anticancer agents may inhibit the progression of Alzheimer's disease (AD) pathology. Conyza dioscoridis (L.) was demonstrated to have anticancer, antioxidant, anti-inflammatory and antidiabetic effects. This study was carried out to investigate the efficacy of polyphenols from Conyza dioscoridis (L.) extract (PCDE) on AD. Methods Impacts of 3 doses of PCDE and donepezil, a reference drug, on the features of Alzheimer's disease in two animal models were investigated. Results PCDE ameliorated the memory and learning impairment shown in rats following a single dose of scopolamine (scopolamine model) or 17 weeks of high-fat/high-fructose(HF/Hfr) diet coupled with a single dose of streptozotocin, (25 mg/kg) (T2D model). They reduced significantly the high hippocampal cholinesterase activity in the two models of rats. Administration of PCDE for 8 weeks in the T2D model showed a significant reduction in hippocampal GSK-3β, caspase-3 activity and increase in the inhibited glutamate receptor expression (AMPA GluR1 subunit and NMDA receptor subunits NR1, NR2A, NR2B). A significant reduction of HOMA-insulin resistance and serum hypercholesterolemia was observed. The Tau hyperphosphorylation and Aβ 1–42 generation in the hippocampal of T2D rats were significantly decreased by PCDE. Modulation of the oxidative stress markers, (rise in GH and SOD; decrease in MDA levels) and a significant reduction of TNF-α and IL-1β in the hippocampus of T2D rats treated by PCDE extract were important findings in this study. The highest dose tested was 4% of the highest safe dose. Conclusion Our study suggests that PCDE is multi-targeting agent with multiple beneficial activities in combating features of AD. This study may provide a novel therapeutic strategy for AD treatment that warrants clinical studies.

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“…The regular consumption of adequate amounts of fruit and vegetables may reduce the incidence of cancer, and this evidence raised interest in the therapeutic use of these foods as natural sources of anticancer agents. This possibility has triggered the attention of researchers, and currently a huge body of evidence supports the anticancer action of naturally occurring compounds [ 31 , 32 ]. Being a rich source of health beneficial nutrients (carbohydrates, vitamins, minerals, fibers, etc.)…”

Section: Discussionmentioning

confidence: 99%

Targeting Proteolysis with Cyanogenic Glycoside Amygdalin Induces Apoptosis in Breast Cancer Cells

et al. 2022

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Background: Breast cancer is the most diagnosed cancer among women, and its incidence and mortality are rapidly growing worldwide. In this regard, plant-derived natural compounds have been shown to be effective as chemotherapeutic and preventative agents. Apricot kernels are a rich source of nutrients including proteins, lipids, fibers, and phenolic compounds and contain the aromatic cyanogenic glycoside amygdalin that has been shown to exert a cytotoxic effect on cancer cells by affecting the cell cycle, inducing apoptosis, and regulating the immune function. Methods: Here, we describe a previously unexplored proapoptotic mechanism of action of amygdalin in breast cancer (MCF7) cells that involves the modulation of intracellular proteolysis. For comparative purposes, the same investigations were also conducted upon cell treatment with two apricot kernel aqueous extracts from Prunus armeniaca L. Results: We observed that both the 20S and 26S proteasome activities were downregulated in the MCF7 cells upon 24 h treatments. Simultaneously, the autophagy cascade resulted in being impaired due to cathepsin B and L inhibition that also contributed to a reduction in cancer cell migration. The inhibition of these proteolytic systems finally promoted the activation of apoptotic events in the MCF7 cells. Conclusion: Collectively, our data unveil a novel mechanism of the anticancer activity of amygdalin, prompting further investigations for potential application in cancer preventative strategies.

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Natural Products for Cancer Therapy: A Review of Their Mechanism of Actions and Toxicity in the Past Decade

Cited by 43 publications

References 144 publications

Extracts of Spiraea hypericifolia L. and Spiraea crenata L.: The Phenolic Profile and Biological Activities

Extracts of Spiraea hypericifolia L. and Spiraea crenata L.: The Phenolic Profile and Biological Activities

RETRACTED ARTICLE: Polyphenols from Conyza dioscoridis (L.) ameliorate Alzheimer’s disease- like alterations through multi-targeting activities in two animal models

Targeting Proteolysis with Cyanogenic Glycoside Amygdalin Induces Apoptosis in Breast Cancer Cells

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