Natural Products for Cancer Prevention: Clinical Update 2016

Sanders, Kathleen; Moran, Zelda; Shi, Zaixing; Paul, Rachel; Greenlee, Heather

doi:10.1016/j.soncn.2016.06.001

Cited by 49 publications

(37 citation statements)

References 133 publications

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“…Natural products have historically been a critical source of anti-cancer agents, and some of them are currently used in clinical practice [ 27 , 28 ]. Natural products are widely studied as potential therapeutic agents because they are highly effective and less toxicity.…”

Section: Discussionmentioning

confidence: 99%

Licochalcone A Inhibits the Proliferation of Human Lung Cancer Cell Lines A549 and H460 by Inducing G2/M Cell Cycle Arrest and ER Stress

Qiu

Zhang

et al. 2017

IJMS

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Licochalcone A (LicA), a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch, has wide spectrum of pharmacological activities. In this study, the anti-cancer effects and potential mechanisms of LicA in non-small cell lung cancer (NSCLC) cells were studied. LicA decreased cell viability and induced apoptosis in a dose-dependent manner in NSCLC cells. LicA inhibited lung cancer cells growth by blocking cell cycle progression at the G2/M transition and inducing apoptosis. LicA treatment decreased the expression of MDM2, Cyclin B1, Cdc2 and Cdc25C in H460 and A549 cancer cell lines. In addition, LicA induced caspase-3 activation and poly-ADP-ribose polymerase (PARP) cleavage, which displayed features of apoptotic signals. Furthermore, LicA increased the expression of endoplasmic reticulum (ER) stress related proteins, such as p-EIF2α and ATF4. These data provide evidence that LicA has the potential to be used in the treatment of lung cancer.

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Section: Discussionmentioning

confidence: 99%

Licochalcone A Inhibits the Proliferation of Human Lung Cancer Cell Lines A549 and H460 by Inducing G2/M Cell Cycle Arrest and ER Stress

Qiu

Zhang

et al. 2017

IJMS

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“…As explained above, NRF2 activators fall into the class of electrophilic and non-electrophilic compounds [66] and can be of natural origin or semisynthetic/synthetic analogs [64]. As reviewed by Sanders et al [107], phenolic and sulfur-containing compounds are the most promising agents in cancer prevention. Phenolic compounds such as curcumin and resveratrol exert their chemopreventive effect via activation of NRF2-KEAP1 signaling that induces phase-II detoxifying and antioxidant enzymes (20638930).…”

Section: Potential Use Of Nrf2 Activators In Cancer Therapymentioning

confidence: 99%

Potential Applications of NRF2 Modulators in Cancer Therapy

et al. 2020

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The nuclear factor erythroid 2-related factor 2 (NRF2)–Kelch-like ECH-associated protein 1 (KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from oxidative, electrophilic, and xenobiotic stress. By controlling the transactivation of over 500 cytoprotective genes, the NRF2 transcription factor has been implicated in the physiopathology of several human diseases, including cancer. In this respect, accumulating evidence indicates that NRF2 can act as a double-edged sword, being able to mediate tumor suppressive or pro-oncogenic functions, depending on the specific biological context of its activation. Thus, a better understanding of the mechanisms that control NRF2 functions and the most appropriate context of its activation is a prerequisite for the development of effective therapeutic strategies based on NRF2 modulation. In line of principle, the controlled activation of NRF2 might reduce the risk of cancer initiation and development in normal cells by scavenging reactive-oxygen species (ROS) and by preventing genomic instability through decreased DNA damage. In contrast however, already transformed cells with constitutive or prolonged activation of NRF2 signaling might represent a major clinical hurdle and exhibit an aggressive phenotype characterized by therapy resistance and unfavorable prognosis, requiring the use of NRF2 inhibitors. In this review, we will focus on the dual roles of the NRF2-KEAP1 pathway in cancer promotion and inhibition, describing the mechanisms of its activation and potential therapeutic strategies based on the use of context-specific modulation of NRF2.

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“…Cancer chemoprevention is associated with the application of natural or synthetic chemical agents to minimize the risk of cancer development. 29 , 30 One of the possible and the most commonly described approaches to achieve effective cancer chemoprevention involves the induction of cytoprotective and detoxifying enzymes. The expression of these inducible genes is regulated by the Nrf2/Keap1 signaling pathway.…”

Section: Nrf2 Modulators For Cancer Prevention and Therapymentioning

confidence: 99%

Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review

Sova

Saso²

2018

DDDT

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A major cell defense mechanism against oxidative and xenobiotic stress is mediated by the Nrf2/Keap1 signaling pathway. The Nrf2/Keap1 pathway regulates gene expression of many cytoprotective and detoxifying enzymes, thus playing a pivotal role in maintaining redox cellular homeostasis. Many diseases including cancer have been closely related to impaired Nrf2 activity. Targeting Nrf2 and modulating its activity represents a novel modern strategy for cancer chemoprevention and therapy. In this review, different design strategies used for the development of Nrf2 modulators are described in detail. Moreover, the main focus is on important and recently developed Nrf2 activators and inhibitors, their in vitro and in vivo studies, and their potential use as chemopreventive agents and/or cancer therapeutics.

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Natural Products for Cancer Prevention: Clinical Update 2016

Cited by 49 publications

References 133 publications

Licochalcone A Inhibits the Proliferation of Human Lung Cancer Cell Lines A549 and H460 by Inducing G2/M Cell Cycle Arrest and ER Stress

Licochalcone A Inhibits the Proliferation of Human Lung Cancer Cell Lines A549 and H460 by Inducing G2/M Cell Cycle Arrest and ER Stress

Potential Applications of NRF2 Modulators in Cancer Therapy

Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review

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