Natural products exert anti-tumor effects by regulating exosomal ncRNA

Hu, Shuang; Liu, Yi; Guan, Shuguang; Qiu, Zhidong; Li, Da

doi:10.3389/fonc.2022.1006114

Cited by 8 publications

(5 citation statements)

References 148 publications

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“…Chemoresistance hinders the growth of health. Chemotherapeutic drug exposure produces an increase in cancer-associated fibroblast exosomes expressing the microRNA miR-146a (CAFs) [ 109 – 111 ]. Thereafter, recipient epithelial cells are encouraged to produce the chemo-resistant protein Snail, which enhances cell proliferation and drug resistance.…”

Section: Functionmentioning

confidence: 99%

Impact of exosome therapy on pancreatic cancer and its progression

et al. 2023

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Pancreatic cancer, one of the most aggressive tumors, has a dismal prognosis because of the low rates of early identification, fast progression, difficulties following surgery, and the ineffectiveness of current oncologic therapies. There are no imaging techniques or biomarkers that can accurately identify, categorize, or predict the biological behavior of this tumor. Exosomes are extracellular vesicles that play a crucial rule in the progression, metastasis, and chemoresistance of pancreatic cancer. They have been verified to be potential biomarkers for pancreatic cancer management. Studying the role of exosomes in pancreatic cancer is substantial. Exosomes are secreted by most eukaryotic cells and participated in intercellular communication. The components of exosomes, including proteins, DNA, mRNA, microRNA, long non-coding RNA, circular RNA, etc., play a crucial role in regulating tumor growth, metastasis, and angiogenesis in the process of cancer development, and can be used as a prognostic marker and/or grading basis for tumor patients. Hereby, in this concise review, we intend to summarize exosomes components and isolation, exosome secretion, function, importance of exosomes in the progression of pancreatic cancer and exosomal miRNAs as possible pancreatic cancer biomarkers. Finally, the application potential of exosomes in the treatment of pancreatic cancer, which provides theoretical supports for using exosomes to serve precise tumor treatment in the clinic, will be discussed.

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Section: Functionmentioning

confidence: 99%

Impact of exosome therapy on pancreatic cancer and its progression

et al. 2023

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“…Fan Ruolan and Chen Hailan found that C. rhamnose could bind to rhSTAT3 protein and inhibit STAT3 phosphorylation at the Tyr705 site, with significant anti-CRC activity [ 111 ]. Curcumin, a natural compound derived from natural products of the ginger and tannin families, inhibited the survival of human colon cancer HCT116 cells.…”

Section: Histone Phosphorylation Regulates Crcmentioning

confidence: 99%

Histone Modification of Colorectal Cancer by Natural Products

Geng

Guo

et al. 2023

Pharmaceuticals

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Natural products play important roles in the pathogenesis of many human malignancies, including colorectal cancer, and can act as a gene regulator in many cancers. They regulate malignant cell growth through many cellular signal pathways, including Rac family small GTPase 1 (RAC1)/PI3K/AKT (α-serine/threonine-protein kinase), mitogen-activated protein kinase (MAPK), Wnt/β-catenin pathway, transforming growth factor-β (TGF-β), Janus kinase and signal transducer and activator of transcription (JAK-STAT), nuclear factor kappa-B (NF-κB), the Notch pathway, Hippo pathway, and Hedgehog pathway. In this review, we describe the epigenetic roles of several natural products, e.g., platycodin D (PD), ginsenoside Rd, tretinoin, Rutin, curcumin, clove extract, betulinic acid, resveratrol, and curcumin, in colorectal cancer, including their impact on colorectal cancer cell proliferation, apoptosis, invasion, migration, and anti-chemotherapeutic resistance. The aim is to illustrate the epigenetic mechanisms of action of natural products in cancer prevention and treatment, and to provide (1) a theoretical basis for the study of the role of epigenetics in influencing colorectal cancer; (2) new directions for studying the occurrence, development, and prognosis of colorectal cancer; and (3) new targets for treating and preventing colorectal cancer.

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“…In recent years, the extraction technology and products of essential oils have also greatly promoted the progress of drug discovery for breast cancer. Through breast cancer clinical experiments, it has been shown that diverse medicinal plant extracts, essential oils and natural bioactive compounds have anti-cancer activities in preclinical breast cancer models [37] In addition, the pharmacometric literature related to the key words of "drug delivery" (2020-2022), "nanoparticle" (2020-2022), "binding " (2020-2022) also generated a lot of articles, which provided research ideas for the development of novel anti breast cancer drugs [38][39][40].…”

Section: Analysis Of Countries and Regions Publishing Papersmentioning

confidence: 99%

Research Progress of Natural Drugs for Breast Cancer in the Past 30 Years Based on Bibliometric and Knowledge Graph Analysis

Gao¹,

Yang²,

Xue³

et al. 2023

Preprint

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Breast cancer is one of the most common types of malignant tumors worldwide and the leading cause of cancer-related deaths in women. According to the latest report from the World Health Organization, breast cancer has surpassed lung cancer, becoming the most diagnosed cancer globally. Herein, a systematic, quantitative, and visual analysis of the scientific achievements in natural products research and development for breast cancer over the past 30 years is presented. The study utilizes bibliometric and knowledge graph visualization techniques to analyze the trends, co-occurrence of keywords, cooperative networks, cited literature, and research hotspots in the field. The analysis shows that breast cancer natural drug development involves mutual cooperation between multiple countries, with China, the United States, and India being the most active players. Pharmacology is the discipline with the largest number of articles published in nearly 30 years. The study also reveals that the extraction of drugs from organisms and their metabolites is an important direction in the current development of anticancer drugs. The development of natural medicines for breast cancer together with the mining of genetic knowledge play an important role in treating human breast cancer. The research presented here provides insights into the current state of natural product research and development for breast cancer, and highlights the need for strengthening mutual communication and cooperation between countries and scientific research institutions to enhance the development of breast cancer treatment technologies and natural medicines.

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Natural products exert anti-tumor effects by regulating exosomal ncRNA

Cited by 8 publications

References 148 publications

Impact of exosome therapy on pancreatic cancer and its progression

Impact of exosome therapy on pancreatic cancer and its progression

Histone Modification of Colorectal Cancer by Natural Products

Research Progress of Natural Drugs for Breast Cancer in the Past 30 Years Based on Bibliometric and Knowledge Graph Analysis

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