Natural products derived from medicinal plants and microbes might act as a game-changer in breast cancer: a comprehensive review of preclinical and clinical studies

Singla, Rajeev K.; Wang, Xiaoyan; Gundamaraju, Rohit; Joon, Shikha; Tsagkaris, Christos; Behzad, Sahar; Khan, Johra; Gautam, Rupesh K.; Goyal, Rajat; Rakmai, Jaruporn; Dubey, Ankit Kumar; Simal-Gándara, Jesús; Shen, Bairong

doi:10.1080/10408398.2022.2097196

Cited by 13 publications

(8 citation statements)

References 454 publications

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“…Accordingly, plant-derived bioactive agents are particularly interesting for researchers and clinicians due to their multiple modes of action in preventing and controlling BC, as well as their availability in our diets. Clinical trials suggest that such products could potential significantly increase the effectiveness of conventional antitumor agents—and decrease their side effects [ 64 ].…”

Section: Natural Antioxidants In the Prevention And Treatment Of Brea...mentioning

confidence: 99%

Control of Redox Homeostasis by Short-Chain Fatty Acids: Implications for the Prevention and Treatment of Breast Cancer

2023

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Breast cancer is the leading cause of death among women worldwide, and certain subtypes are highly aggressive and drug resistant. As oxidative stress is linked to the onset and progression of cancer, new alternative therapies, based on plant-derived compounds that activate signaling pathways involved in the maintenance of cellular redox homeostasis, have received increasing interest. Among the bioactive dietary compounds considered for cancer prevention and treatment are flavonoids, such as quercetin, carotenoids, such as lycopene, polyphenols, such as resveratrol and stilbenes, and isothiocyanates, such as sulforaphane. In healthy cells, these bioactive phytochemicals exhibit antioxidant, anti-apoptotic and anti-inflammatory properties through intracellular signaling pathways and epigenetic regulation. Short-chain fatty acids (SCFAs), produced by intestinal microbiota and obtained from the diet, also exhibit anti-inflammatory and anti-proliferative properties related to their redox signaling activity—and are thus key for cell homeostasis. There is evidence supporting an antioxidant role for SCFAs, mainly butyrate, as modulators of Nrf2-Keap1 signaling involving the inhibition of histone deacetylases (HDACs) and/or Nrf2 nuclear translocation. Incorporation of SCFAs in nutritional and pharmacological interventions changes the composition of the the intestinal microbiota, which has been shown to be relevant for cancer prevention and treatment. In this review, we focused on the antioxidant properties of SCFAs and their impact on cancer development and treatment, with special emphasis on breast cancer.

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Section: Natural Antioxidants In the Prevention And Treatment Of Brea...mentioning

confidence: 99%

Control of Redox Homeostasis by Short-Chain Fatty Acids: Implications for the Prevention and Treatment of Breast Cancer

2023

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“…The investigation on the effects of extracts from Urtica membranaceae, Artemesia monosperma, and Origanum dayi poston a wide range of cancer cell lines from lung, breast, colon, and prostate cancers showed that plant extracts with a combination of anti-cancer compounds were able to have a killing activity which was specific to cancer cells and showed no effect on normal human lymphocytes and fibroblasts. This makes plant extracts more desirable as therapeutic agents than chemically derived ones, which cause toxic complications in cancer treatment 46,47 . The approved plant-derived anti-tumour compounds are Vinblastine (Velban), Vincristine (Oncovin), Etoposide, Teniposide, Taxol (paclitaxel), Navelbine (Vinorelbine), Taxotere (Docetaxel), Camptothecin (Camptosar, Campto), Topotecan (Hycamtin) and Irinotecan.…”

Section: Plant Compounds With Anticancer Propertiesmentioning

confidence: 99%

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2022

IJPSR

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Traditional Chinese Medicine (TCM) have been extensively documented over the past thousands of years 1 . The written records of Ayurveda, the Indian medicinal system, originated before the 1 st millennium BC 2 . However, logical drug discovery from plants commenced at the beginning of the 19 th century, when Friedrich Serturner successfully extracted an analgesic and sleep-inducing agent from the Opium poppy, themorphium (morphine) that, was named after Morpheus, the Greek god of dreams. He thoroughly discussed isolation, crystallization,

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“…In response, phytocompounds are gaining recognition as promising chemotherapeutic and chemopreventive agents in cancer therapy, as they can be derived from medicinal plants and exhibit the potential to treat and prevent cancer. The present study specifically focused on the characterization and examination of the phytochemical composition of Bitter almond seed, intending to identify a popular phytocompound dual suppressor for EGFR as well as HER2 that can demonstrate anti-cancer activity via molecular docking as well as dynamic simulation investigations [ 2 , 3 , 7 , 20 ]. This study expands upon previous research efforts aimed at uncovering new, naturally derived bioactive compounds with anti-cancer properties, and it will be expanded to show the anti-cancer activity of the crude extract as dose-dependent on 8 cancer cell lines (phase 2).…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, natural Pharmaceuticals 2023, 16, 704 2 of 23 compounds have emerged as promising candidates for the treatment of cancer due to their ability to target specific signaling pathways involved in cancer progression [2]. There is a growing body of research exploring the use of natural compounds as alternative or complementary therapies for cancer [3].…”

Section: Introductionmentioning

confidence: 99%

Diosgenin and Monohydroxy Spirostanol from Prunus amygdalus var amara Seeds as Potential Suppressors of EGFR and HER2 Tyrosine Kinases: A Computational Approach

et al. 2023

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Cancer continues to be leading cause of death globally, with nearly 7 million deaths per year. Despite significant progress in cancer research and treatment, there remain several challenges to overcome, including drug resistance, the presence of cancer stem cells, and high interstitial fluid pressure in tumors. To tackle these challenges, targeted therapy, specifically targeting HER2 (Human Epidermal Growth Factor Receptor 2) as well as EGFR (Epidermal Growth Factor Receptor), is considered a promising approach in cancer treatment. In recent years, phytocompounds have gained recognition as a potential source of chemopreventive and chemotherapeutic agents in tumor cancer treatment. Phytocompounds are compounds derived from medicinal plants that have the potential to treat and prevent cancer. This study aimed to investigate phytocompounds from Prunus amygdalus var amara seeds as inhibitors against EGFR and HER2 enzymes using in silico methods. In this study, fourteen phytocompounds were isolated from Prunus amygdalus var amara seeds and subjected to molecular docking studies to determine their ability to bind to EGFR and HER2 enzymes. The results showed that diosgenin and monohydroxy spirostanol exhibited binding energies comparable to those of the reference drugs, tak-285, and lapatinib. Furthermore, the drug-likeness and ADMET predictions, performed using the admetSAR 2.0 web-server tool, suggested that diosgenin and monohydroxy spirostanol have similar safety and ADMET properties as the reference drugs. To get deeper insight into the structural steadiness and flexibility of the complexes formed between these compounds and theEGFR and HER2 proteins, molecular dynamics simulations were performed for 100 ns. The results showed that the hit phytocompounds did not significantly affect the stability of the EGFR and HER2 proteins and were able to form stable interactions with the catalytic binding sites of the proteins. Additionally, the MM-PBSA analysis revealed that the binding free energy estimates for diosgenin and monohydroxy spirostanol is comparable to the reference drug, lapatinib. This study provides evidence that diosgenin and monohydroxy spirostanol may have the potential to act as dual suppressors of EGFR and HER2. Additional in vivo and in vitro research are needed to certify these results and assess their efficacy and safety as cancer therapy agents. The experimental data reported and these results are in agreement.

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Natural products derived from medicinal plants and microbes might act as a game-changer in breast cancer: a comprehensive review of preclinical and clinical studies

Cited by 13 publications

References 454 publications

Control of Redox Homeostasis by Short-Chain Fatty Acids: Implications for the Prevention and Treatment of Breast Cancer

Control of Redox Homeostasis by Short-Chain Fatty Acids: Implications for the Prevention and Treatment of Breast Cancer

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Diosgenin and Monohydroxy Spirostanol from Prunus amygdalus var amara Seeds as Potential Suppressors of EGFR and HER2 Tyrosine Kinases: A Computational Approach

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