Natural Products Chemistry: Advances in Synthetic, Analytical and Bioactivity Studies

Ribaudo, Giovanni

doi:10.3390/molecules28145577

Cited by 1 publication

(1 citation statement)

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“…This can include the change in nature and positioning of substituents, the introduction of peculiar functional groups and chirality centers, 3D shaping, etc., which enrich the intrinsic value and complexity of natural compounds. 9,10 Among different groups of nature-derived structures amino acids are an essential part of the modern medicinal chemist's repertoire and the primary substances supporting biological life activities. They are responsible for vital physiological functions, being building blocks for the protein synthesis, acting as precursors for signaling molecules and energy metabolites, maintaining and regulating body development, osmotic pressure stability, and neurotransmission.…”

Section: Introductionmentioning

confidence: 99%

EFFICIENT MULTIGRAM SYNTHESIS OF 3,3-Spiro-Α-Proline CONTAINING CHIMERAS

Derkach,

Levchenko,

Iermolenko

et al. 2024

Preprint

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A series of novel spirocyclic α-proline building blocks for drug discovery with a spiro conjunction in position 3 of pyrrolidine was prepared by means of two convenient and practical synthetic approaches. Both alternative routes utilize simple and easily available starting materials – cyclic ketones and esters – and comprise 6- and 7-steps, respectively. The methodologies feature several advantages, including exploitation of simple organic chemistry transformations and suitability for preparation of multigram amounts of the target prolines. Approach to other valuable chemicals – spirocyclic pyroglutamic acids – is also discussed.

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Section: Introductionmentioning

confidence: 99%