Natural products as Zika antivirals

Fong, Yuhui Deborah; Chu, Justin Jang Hann

doi:10.1002/med.21891

Cited by 21 publications

(20 citation statements)

References 117 publications

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“…F-6 and FAc-2 fractions abundant in cyclic diterpenes with aldehyde groups from Dictyota menstrualis , a brown seaweed in Brazil, have potent anti-viral activity against ZIKV [ 81 ]. Polyphenols such as delphinidin and epigallocatechin gallate, which are available in natural products such as wine and tea, exhibited antiviral activity against ZIKV in an in vitro model [ 82 , 83 ]. Berberine, an isoquinoline alkaloid seen in Berberis vulgaris, as well as Emodin, an anthraquinone derivative available in Rheum palmatum , Polygonum multiflorum , Aloe vera , and Cassia obtusifolia were found to have anti-viral activity against ZIKV [ 84 ].…”

Section: Nutraceuticals Against Zikv Infectionmentioning

confidence: 99%

Novel Therapeutic Nutrients Molecules That Protect against Zika Virus Infection with a Special Note on Palmitoleate

et al. 2022

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Zika virus (ZIKV) is a Flavivirus from the Flaviviridae family and a positive-sense single strand RNA virus. ZIKV infection can cause a mild infection to the mother but can be vertically transmitted to the developing fetus, causing congenital anomalies. The prevalence of ZIKV infections was relatively insignificant with sporadic outbreaks in the Asian and African continents until 2006. However, recent epidemic in the Caribbean showed significant increased incidence of Congenital Zika Syndrome. ZIKV infection results in placental pathology which plays a crucial role in disease transmission from mother to fetus. Currently, there is no Food and Drug Administration (FDA) approved vaccine or therapeutic drug against ZIKV. This review article summarizes the recent advances on ZIKV transmission and diagnosis and reviews nutraceuticals which can protect against the ZIKV infection. Further, we have reviewed recent advances related to the novel therapeutic nutrient molecules that have been shown to possess activity against Zika virus infected cells. We also review the mechanism of ZIKV-induced endoplasmic reticulum and apoptosis and the protective role of palmitoleate (nutrient molecule) against ZIKV-induced ER stress and apoptosis in the placental trophoblasts.

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Section: Nutraceuticals Against Zikv Infectionmentioning

confidence: 99%

Novel Therapeutic Nutrients Molecules That Protect against Zika Virus Infection with a Special Note on Palmitoleate

et al. 2022

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“…These successful cases mainly focused on various tumor treatment by loading various chemotherapy agents and controlling their release behavior. 6−9 Many natural products have been found to significant and extensive pharmacological properties, such as anti-inflammatory, 10,11 antiviral, 12 antiparasitic, 13 and antitumor activities. 14−16 However, the low aqueous solubility and poor in vivo biodistribution of these active compounds required a suitable drug delivery system to achieve the desired therapeutic effect.…”

mentioning

confidence: 99%

“…Many natural products have been found to significant and extensive pharmacological properties, such as anti-inflammatory, , antiviral, antiparasitic, and antitumor activities. − However, the low aqueous solubility and poor in vivo biodistribution of these active compounds required a suitable drug delivery system to achieve the desired therapeutic effect. Our group has incorporated active flavonoid compound rutin into a G 4 hydrogel by a unique catechol moiety, presenting stimuli-responsive release for the treatment of inflammatory bowel disease (IBD) .…”

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confidence: 99%

Guanosine-Based Multidrug Strategy Delivery for Synergistic Anti-Inflammation

Gao,

Zhang,

Wang

et al. 2024

ACS Macro Lett.

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The development of codelivery approaches for combination therapy is of great significance, especially for natural products that need to be combined to achieve therapeutic effects. Targeted delivery of multiple drugs through a single carrier remains a challenge. Here, a multi-drug-loaded hydrogel, incorporating quercetin, demethyleneberberine, and dencichine, based on a G 4quadruplex was designed and prepared. Catechol drugs were responsively released in a simulated inflammatory pathological environment by a borate ester linkage, while coagulating dencichine encapsulated in the hydrogel was released along with the degradation of assemblies. The multi-drug-loaded codelivery system is expected to enhance the treatment of inflammatory bowel disease through the synergistic effect of the components. The preparation, characteristic, and physicochemical properties of the multi-drug-loaded assembly were depicted by NMR, CD, and TEM. Degradation assays in vitro proved the good biocompatibility and safety of the hydrogel and a potential pathway to injectable administration. The assays of typical inflammatory cytokines, including TNF-α and IL-6, indicated that these can be significantly suppressed by the treatment of the hydrogel. The current work provided a simple strategy to construct a multi-drug-loaded hydrogel carrier, which facilitated synergistic therapy for natural products by a codelivery approach.

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“…The urgent need for effective treatments for ZIKV infection became a main research focus in discovering and identifying potential antiviral drug targets and compounds with inhibitory activity potential. In recent years, natural product-derived compounds have emerged as an important source for anti-ZIKV drugs. − …”

mentioning

confidence: 99%

“…A conjugated carbonyl group at C-7 in 10 was confirmed by the HMBC correlations from H 2 -6 (δ H 2.76, dd, J = 17.6, 3.4 Hz; 2.63, dd, J = 17.6, 14.2 Hz) and H-14 (δ H 7.93, s) to C-7 (δ C 199.0). An endocyclic Δ 6 (7) double bond at C-6 and C-7 in 11 was detected by observing 1 H− 1 H COSY correlations of H-5 (δ H 2.4, t, J = 3.0 Hz)/H-6 (δ H 6.01, dd, J = 9.6, 3.0 Hz)/H-7 (δ H 6.61, dd, J = 9.6, 3.0 Hz), further confirmed by HMBC correlations of H-6 with C-5 (δ C 51.6) and H-7 with C-14 (δ C 119.9). The ROESY correlation and NMR data of H-5 and H 3 -20 in 9−11 corresponded to those of compounds 6−8, enabling the assignment of the relative configurations of H-5 (10 and 11) and H 3 -20 (9−11) as αand β-oriented, respectively.…”

mentioning

confidence: 99%

Wulfenioidins D–N, Structurally Diverse Diterpenoids with Anti-Zika Virus Activity Isolated from Orthosiphon wulfenioides

Tu,

Huang,

et al. 2023

J. Nat. Prod.

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Eleven diterpenoids, wulfenioidins D−N (1−11), classified into five distinct carbon skeletons with one unreported framework, and four modified abietane diterpenoids were isolated from the whole plant of Orthosiphon wulfenioides. The structures and absolute configurations were characterized by spectroscopic methods, singlecrystal X-ray diffraction, and electronic circular dichroism analyses. Compounds 3 and 5 exhibited activity against Zika virus (ZIKV) with EC 50 values of 8.07 and 8.50 μM, respectively, and showed no significant cytotoxicity toward Vero cells at 100 μM. Western blot and immunofluorescence experiments showed that compounds 3 and 5 interfered with the replication of the ZIKV by inhibiting the expression of the ZIKV envelope (E) protein.

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Natural products as Zika antivirals

Cited by 21 publications

References 117 publications

Novel Therapeutic Nutrients Molecules That Protect against Zika Virus Infection with a Special Note on Palmitoleate

Novel Therapeutic Nutrients Molecules That Protect against Zika Virus Infection with a Special Note on Palmitoleate

Guanosine-Based Multidrug Strategy Delivery for Synergistic Anti-Inflammation

Wulfenioidins D–N, Structurally Diverse Diterpenoids with Anti-Zika Virus Activity Isolated from Orthosiphon wulfenioides

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