Natural Products as Trypanocidal, Antileishmanial and Antimalarial Drugs

Fournet, Alain; Muñoz, Verónica Francisca Loewe

doi:10.2174/1568026023393011

Cited by 119 publications

(81 citation statements)

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“…Malaria is one of the most important parasitic diseases in the world and is a major global health problem affecting over one hundred countries with disease prevalence escalating at an alarming rate, particularly in the last two decades. Rapid development of resistance by Plasmodium falciparum to the conventional drugs such as chloroquine necessitates the search for new antimalarials (Iwu et al, 1994;Wolf, 2002;Guerin et al, 2002;Fournet and Munoz, 2002). Malaria, a devastating infectious disease caused by highly adaptable protozoan parasites of the genus Plasmodium, has impacted on humans for more than 4000 years, causing illness and an estimated 1.5-2.5 million deaths each year.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of three medicinal plant extracts against Plasmodium falciparum and selected microganisms

Falodun¹,

Imieje²,

Erharuyi³

et al. 2014

Afr. J. Trad. Compl. Alt. Med.

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Background: A great revival of scientific interests in drug discovery has been witnessed in recent years from medicinal plants for health maintenance. The aim of this work was to investigate three Nigerian medicinal plants collected in Nigeria for their in vitro antiplasmodial and antimicrobial activities. Materials and Methods: Extracts obtained from parts of Persea americana, Jatropha podagrica and Picralima nitida and their fractions were evaluated for in vitro antiprotozoal and antimicrobial activity. Result: The methanol extract of P. nitida demonstrated activity against chloroquine-sensitive and chloroquine-resistant P. falciparum clones with IC 50 values of 6.3 and 6.0 µg/mL, respectively. Methanol and chloroform extracts of P. americana seed showed antifungal activity against Cryptococcus neoformans IC 50 less than 8 and 8.211 µg/mL respectively. Finally, the petroleum ether extract of P. americana had activity against methicillinresistant Staphylococcus aureus (MRSA) with an IC 50 value of 8.7 µg/mL. Conclusion: The study revealed the antibacterial and antiplasmodial activities of the plants extracts at the tested concentrations.

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Section: Introductionmentioning

confidence: 99%

Evaluation of three medicinal plant extracts against Plasmodium falciparum and selected microganisms

Falodun¹,

Imieje²,

Erharuyi³

et al. 2014

Afr. J. Trad. Compl. Alt. Med.

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“…Natural products have become a key source of new drugs in the last years (Fournet and Muñoz, 2002;Newman and Cragg, 2007). The Euphorbia genus includes a wide and diverse group of plants which are characterized by the presence of an irritant latex rich in euphol and euphorbol triterpenes (Singla and Pathak, 1990).…”

Section: Introductionmentioning

confidence: 99%

Antileishmanial and Antitrypanosomal Activity of Triterpene Derivatives from Latex of Two Euphorbia Species

Mazoir

Benharref

Bailén

et al. 2011

Zeitschrift Für Naturforschung C

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The in vitro activity on Leishmania infantum promastigotes and Trypanosoma cruzi epimastigotes of 25 semisynthetic terpenoid derivatives has been evaluated. These compounds were obtained through chemical modifications of the major components of Euphorbia resinifera (α-euphol and α-euphorbol) and Euphorbia officinarum (obtusifoliol and 31-norlanosterol). Leishmaniasis and Chagas´ disease are major worldwide health problems. The drugs of choice for their treatment are still problematic in both cases, and therefore there is an urgent need to discover new drugs with high activity and low side effects. Natural products have become a key source of new drugs in the last years. The genus Euphorbia has been the subject of abundant phytochemical and pharmacological research because of its potential medical applications, but the antiparasitic effects of derivatives from plants of this genus are still unknown. Our results showed that 76% and 64% of the test compounds had antiparasitic effects on L. infantum and T. cruzi, respectively. The different activities on both parasites, especially their moderate effects on mammalian cells, indicate an interesting selective toxicity.

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“…Efforts in the last two decades 8,[14][15][16][17][18] suggest that plants may provide the much needed clue for the emergence of the long awaited new generation of trypanocidal drugs. In line with this trend, we investigated different solvent extracts of different parts of Prosopis africana for in vitro and in vivo trypanocidal activity using Trypanosoma brucei brucei as model.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Anti-trypanosomal Properties of Four Extracts of Leaves, Stem and Root Barks of Prosopis africana in Laboratory Animals

Atawodi¹,

Ogunbusola²

2010

Biokemistri

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Qualitative phytochemical and anti-trypanosomal properties of the petroleum ether, chloroform, methanol and aqueous extracts, obtained by cold extraction from the leaves, stem bark and roots of Prosopis africana were evaluated. The methanolic and aqueous extracts of the stem bark and leaves of the plant contained alkaloids, saponins, tannins and flavonoids. Anthraquinone was present in the stem bark methanolic extract and in the methanolic and aqueous extracts of the root as well as the aqueous extract of the leaves. Resins was present in the petroleum ether and chloroform extracts of the stem bark and leaves, while tannins was detected in the methanol and aqueous extracts of the stem bark and leaves of the plant in addition to the petroleum ether and chloroform extracts of the root bark. All the solvent extracts showed strong in vitro anti-trypanosomal activity and 2 and 4 mg/ml, but in vivo only the methanolic extract of the leaves displayed the most promising anti-trypanosomal effect at 200 mg/kg dose. Hence, Prosopis africana extracts possess significant anti-trypanosomal activity to warrant bioassay-guided evaluation and identification of the active principle.

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Natural Products as Trypanocidal, Antileishmanial and Antimalarial Drugs

Cited by 119 publications

References 0 publications

Evaluation of three medicinal plant extracts against <i>Plasmodium falciparum</i> and selected microganisms

Evaluation of three medicinal plant extracts against <i>Plasmodium falciparum</i> and selected microganisms

Antileishmanial and Antitrypanosomal Activity of Triterpene Derivatives from Latex of Two Euphorbia Species

Evaluation of Anti-trypanosomal Properties of Four Extracts of Leaves, Stem and Root Barks of <i>Prosopis africana</i> in Laboratory Animals

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