Natural Products as Sources of Antimalarial Drugs: Ethnobotanical and Ethnopharmacological Studies

Oladeji, Oluwole Solomon; Oluyori, Abimbola Peter; Bankole, Deborah Temitope; Afolabi, Yemisi Tokunbo

doi:10.1155/2020/7076139

Cited by 28 publications

(14 citation statements)

References 80 publications

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“…Reliance on traditional herbs to treat malaria is more common in developing countries where the majority of the population is unable to access or afford pharmaceutical antimalarial drugs [6,7]. In certain countries in sub-Saharan Africa such as Nigeria, traditional and cultural-based products such as palm wine, fermented foods like pap (ogi), and naturally occurring edible herbs are some of the most common local remedies for malaria [8][9][10]. Specifically, infusions of traditional medicinal plants are often prepared and consumed to treat malaria infections.…”

Section: Introductionmentioning

confidence: 99%

X-ray Structure Determination, Antioxidant Voltammetry Studies of Butein and 2′,4′-Dihydroxy-3,4-dimethoxychalcone. Computational Studies of 4 Structurally Related 2′,4′-diOH Chalcones to Examine Their Antimalarial Activity by Binding to Falcipain-2

Okoye

Caruso

et al. 2021

Molecules

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Malaria is a huge global health burden with resistance to currently available medicines resulting in the search for newer antimalarial compounds from traditional medicinal plants in malaria-endemic regions. Previous studies on two chalcones, homobutein and 5-prenylbutein, present in E. abyssinica, have shown moderate antiplasmodial activity. Here, we describe results from experimental and computational investigations of four structurally related chalcones, butein, 2′,4′-dihydroxy-3,4-dimethoxychalcone (DHDM), homobutein and 5-prenylbutein to elucidate possible molecular mechanisms by which these compounds clear malaria parasites. The crystal structures of butein and DHDM show that butein engages in more hydrogen bonding and consequently, more intermolecular interactions than DHDM. Rotating ring-disk electrode (RRDE) voltammetry results show that butein has a higher antioxidant activity towards the superoxide radical anion compared to DHDM. Computational docking experiments were conducted to examine the inhibitory potential of all four compounds on falcipain-2, a cysteine protease that is involved in the degradation of hemoglobin in plasmodium-infected red blood cells of the host. Overall, this work suggests butein as a better antimalarial compound due to its structural features which allow it to have greater intermolecular interactions, higher antioxidant activity and to create a covalent complex at the active site of falcipain-2.

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Section: Introductionmentioning

confidence: 99%

X-ray Structure Determination, Antioxidant Voltammetry Studies of Butein and 2′,4′-Dihydroxy-3,4-dimethoxychalcone. Computational Studies of 4 Structurally Related 2′,4′-diOH Chalcones to Examine Their Antimalarial Activity by Binding to Falcipain-2

Okoye

Caruso

et al. 2021

Molecules

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“…Botanical pain relievers: Acanthus montanus (Alligator pepper) leaves, Alstonia boonei (Stool wood) [29], Rauvolfia vomitora (Lime orange) leaves, Newboulda laevis (Boundary tree) Stem bark, Byrsocarpus coccineus (Huntsman's pepper) leaves, Sarchocephalus latifolus (African peach) leaves, Diospyros monbuttensis (Yoruba Ebony) leaves, Theobroma cacao (Cocoa) leaves are used as singly or in combination to relieve abdominal pains, muscle aches, headaches and general body pains. The herbal medicines are prepared as leaf juice, concoction, decoction for treatment purposes.…”

Section: Resultsmentioning

confidence: 99%

Traditional Healing Methods: Focus on the Medicinal Plants Against Coronavirus (Covid-19) Infection

Ademola¹,

Akorede²,

Odutola³

et al. 2021

JDMP

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Background: In African health care system, medicinal plants are major components and most assorted of all therapeutic systems. In major parts of rural Africa, traditional healers prescribing medicinal plants are the most easily accessible and affordable health resource available to the local community and at times the only therapy that subsists. Coronavirus diseases (COVID-19) is an acute virus (SARs-coV-2) which has caused a global pandemic. This paper aims to emphasize the importance of herbal medicine as a possible alternative and effective immune system booster against coronavirus disease in Ogun state, Nigeria. Materials and Methods: Ethnobotanical survey was carried out using 80 randomly selected respondents among the villagers, herbalists, herb sellers, traditional medical practitioners, students, community leaders, by oral interviews and semi-structured questionnaire. The data were analyzed using frequency counts and percentages. Results: A total of 81 plant species from 35 families which were mostly represented by Euphorbiaceae, Moraceae, Apocynaceae and Rubiaceae, and 61 botanicals were used singly while 21 other botanicals were combination of two or more plants in a single herbal preparations reported in the study area are used for management and alternative therapy against ailments such as fever, cough, body pain, flu, cold and shortness of breath that are associated to symptoms of covid-19. Conclusion: Herbal medicines provide an alternative therapy for boosting immunity system to help fight coronavirus. Traditional healers are still very relevant to African healthcare system.

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“…Searching for bioactive compounds from medicinal plants is not a new African research initiative. Even so, in previous studies, two key components were lacking in our view: (i) Most of the studies have only been national or regional (e.g., Bouyahya et al ., 2020; Kamau et al ., 2016; Okot et al ., 2020; Oladeji et al ., 2020; Patrick et al ., 2015; Spiegler., 2020; Twilley et al ., 2020). To achieve the same effect and coverage as the traditional Chinese medicine effort, a continental coverage is needed.…”

Section: Conclusion and The Way Forwardmentioning

confidence: 99%

Plant genomics in Africa: present and prospects

et al. 2021

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Plants are the world's most consumed goods. They are of high economic value and bring many health benefits. In most countries in Africa, the supply and quality of food will rise to meet the growing population's increasing demand. Genomics and other biotechnology tools offer the opportunity to improve subsistence crops and medicinal herbs in the continent. Significant advances have been made in plant genomics, which have enhanced our knowledge of the molecular processes underlying both plant quality and yield. The sequencing of complex genomes of African plant species, facilitated by the continuously evolving nextgeneration sequencing technologies and advanced bioinformatics approaches, has provided new opportunities for crop improvement. This review summarizes the achievements of genome sequencing projects of endemic African plants in the last two decades. We also present perspectives and challenges for future plant genomic studies that will accelerate important plant breeding programs for African communities. These challenges include a lack of basic facilities, a lack of sequencing and bioinformatics facilities, and a lack of skills to design genomics studies. However, it is imperative to state that African countries have become key players in the plant genome revolution and genome derived-biotechnology. Therefore, African governments should invest in public plant genomics research and applications, establish bioinformatics platforms and training programs, and stimulate university and industry partnerships to fully deploy plant genomics, particularly in the fields of agriculture and medicine.

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Natural Products as Sources of Antimalarial Drugs: Ethnobotanical and Ethnopharmacological Studies

Cited by 28 publications

References 80 publications

X-ray Structure Determination, Antioxidant Voltammetry Studies of Butein and 2′,4′-Dihydroxy-3,4-dimethoxychalcone. Computational Studies of 4 Structurally Related 2′,4′-diOH Chalcones to Examine Their Antimalarial Activity by Binding to Falcipain-2

X-ray Structure Determination, Antioxidant Voltammetry Studies of Butein and 2′,4′-Dihydroxy-3,4-dimethoxychalcone. Computational Studies of 4 Structurally Related 2′,4′-diOH Chalcones to Examine Their Antimalarial Activity by Binding to Falcipain-2

Traditional Healing Methods: Focus on the Medicinal Plants Against Coronavirus (Covid-19) Infection

Plant genomics in Africa: present and prospects

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