Natural Products as Source of Anti-Inflammatory Drugs

Venkatesha, Shivaprasad H.; Acharya, Bodhraj; Moudgil, Kamal D.

doi:10.1002/9783527692156.ch65

Cited by 6 publications

(10 citation statements)

References 165 publications

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“…Owing to these limitations, an increasing number of patients have started to turn to natural products to relieve symptoms of RA and related ailments [ 67 ], with over 36% of adults in the USA using complementary and alternative (CAM) therapies [ 68 ]. Natural products have been studied extensively in multiple different ailments such as cancer [ 69 ], infectious diseases [ 70 ], and autoimmunity [ 71 , 72 , 73 , 74 , 75 ]. However, difficulties in evaluating the efficacy of these products as well as inadequate information about their mechanism of action are among the reasons for skepticism from both the public and professional communities [ 76 , 77 ].…”

Section: The Use Of Plant Natural Products For Arthritis Therapymentioning

confidence: 99%

“…There are several other natural products besides those described above that possess anti-inflammatory activities and are reported to be beneficial in the treatment of arthritis and some other musculoskeletal disorders in patients and experimental models [ 75 ]. Some of these are summarized in Table 1 .…”

Section: The Use Of Plant Natural Products For Arthritis Therapymentioning

confidence: 99%

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Natural Products for the Treatment of Autoimmune Arthritis: Their Mechanisms of Action, Targeted Delivery, and Interplay with the Host Microbiome

Dudics

Langan

Meka

et al. 2018

IJMS

122

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Rheumatoid arthritis (RA) is a chronic, debilitating illness characterized by painful swelling of the joints, inflammation of the synovial lining of the joints, and damage to cartilage and bone. Several anti-inflammatory and disease-modifying drugs are available for RA therapy. However, the prolonged use of these drugs is associated with severe side effects. Furthermore, these drugs are effective only in a proportion of RA patients. Hence, there is a need to search for new therapeutic agents that are effective yet safe. Interestingly, a variety of herbs and other natural products offer a vast resource for such anti-arthritic agents. We discuss here the basic features of RA pathogenesis; the commonly used animal models of RA; the mainstream drugs used for RA; the use of well-characterized natural products possessing anti-arthritic activity; the application of nanoparticles for efficient delivery of such products; and the interplay between dietary products and the host microbiome for maintenance of health and disease induction. We believe that with several advances in the past decade in the characterization and functional studies of natural products, the stage is set for widespread clinical testing and/or use of these products for the treatment of RA and other diseases.

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Section: The Use Of Plant Natural Products For Arthritis Therapymentioning

confidence: 99%

Section: The Use Of Plant Natural Products For Arthritis Therapymentioning

confidence: 99%

Natural Products for the Treatment of Autoimmune Arthritis: Their Mechanisms of Action, Targeted Delivery, and Interplay with the Host Microbiome

Dudics

Langan

Meka

et al. 2018

IJMS

122

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“…Vertinolides, with the presence of a γ-lactone terminus and a lack of any carbon rings, represent a class of degrading products of monomeric sorbicillinoids [20]. Three vertinolides, namely trichoreesin A (32), (+)-(R)-vertinolide (37), and (−)-(S)-dihydrovertinolide (38), have been isolated from fungi since 2016 [18,21,22]. (+)-(R)-vertinolide (37) is a new natural product isolated from Trichoderma citrinoviride from indoor air [21].…”

Section: Monomeric Sorbicillinoidsmentioning

confidence: 99%

“…(R)-vertinolide (37) differs in stereochemistry from (S)-vertinolide isolated from Verticillium intertextum [23]. (−)-(S)-dihydrovertinolide (38) was isolated from the endophytic fungus Clonostachys rosea B5-2, which was isolated from the mangrove plant Bruguiera gymnorrhiza, collected in the coast of Santolo Garut Beach, West-Java, Indonesia [5,22].…”

Section: Monomeric Sorbicillinoidsmentioning

confidence: 99%

“…Inflammation is a common response of the human body to injuries caused by microbial pathogens, trauma, or toxic compounds. Bioactive metabolites produced by fungi have received considerable attention as new therapeutic agents [38]. Many sorbicillinoids were screened for anti-inflammatory activities and their potential use in the treatment of inflammatory diseases (Table S7).…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

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Recent Advances in Sorbicillinoids from Fungi and Their Bioactivities (Covering 2016–2021)

Hou

Zhang

Xue

et al. 2022

JoF

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Sorbicillinoids are a family of hexaketide metabolites with a characteristic sorbyl side chain residue. Sixty-nine sorbicillinoids from fungi, newly identified from 2016 to 2021, are summarized in this review, including their structures and bioactivities. They are classified into monomeric, dimeric, trimeric, and hybrid sorbicillinoids according to their basic structural features, with the main groups comprising both monomeric and dimeric sorbicillinoids. Some of the identified sorbicillinoids have special structures such as ustilobisorbicillinol A, and sorbicillasins A and B. The majority of sorbicillinoids have been reported from fungi genera such as Acremonium, Penicillium, Trichoderma, and Ustilaginoidea, with some sorbicillinoids exhibiting cytotoxic, antimicrobial, anti-inflammatory, phytotoxic, and α-glucosidase inhibitory activities. In recent years, marine-derived, extremophilic, plant endophytic, and phytopathogenic fungi have emerged as important resources for diverse sorbicillinoids with unique skeletons. The recently revealed biological activities of sorbicillinoids discovered before 2016 are also described in this review.

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A Molecular Insight into Significance of Functional Foods in Better Management of Rheumatoid Arthritis

Guleria

Kamboj

Kaushal

et al. 2022

Rev. Bras. Farmacogn.

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Natural Products as Source of Anti-Inflammatory Drugs

Cited by 6 publications

References 165 publications

Natural Products for the Treatment of Autoimmune Arthritis: Their Mechanisms of Action, Targeted Delivery, and Interplay with the Host Microbiome

Natural Products for the Treatment of Autoimmune Arthritis: Their Mechanisms of Action, Targeted Delivery, and Interplay with the Host Microbiome

Recent Advances in Sorbicillinoids from Fungi and Their Bioactivities (Covering 2016–2021)

A Molecular Insight into Significance of Functional Foods in Better Management of Rheumatoid Arthritis

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