Natural products as biofilm formation antagonists and regulators of quorum sensing functions: A comprehensive review update and future trends

Ćirić, Ana; Petrović, Jovana; Glamočlija, Jasmina; Smiljković, Marija; Nikolić, Miloš; Stojković, Dejan; Soković, Marina

doi:10.1016/j.sajb.2018.09.010

Cited by 47 publications

(20 citation statements)

References 137 publications

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“…The increase in bacterial resistance has aggravated the difficulty of disease prevention, and the side effects caused by excessive use of drugs may also endanger human health. The discovery of control strategies for quorum quenching diseases in recent years has provided new possibilities for overcoming and solving the problem of microbial resistance [101,102]. By interfering with the QS system of specific microorganisms, hindering the exchange of information between microorganisms, and reducing the expression level of hazard factors, this phenomenon is called quorum quenching (QQ) [103,104].…”

Section: New Strategy For Preventive Treatment Of Microbial Resistancementioning

confidence: 99%

Quorum-Sensing Regulation of Antimicrobial Resistance in Bacteria

2020

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Quorum sensing is a cell-to-cell communication system that exists widely in the microbiome and is related to cell density. The high-density colony population can generate a sufficient number of small molecule signals, activate a variety of downstream cellular processes including virulence and drug resistance mechanisms, tolerate antibiotics, and harm the host. This article gives a general introduction to the current research status of microbial quorum-sensing systems, focuses on the role of quorum-sensing systems in regulating microbial resistance mechanisms, such as drug efflux pump and microbial biofilm formation regulation, and discusses a new strategy for the treatment of drug-resistant bacteria proposed by using quorum quenching to prevent microbial resistance.

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Section: New Strategy For Preventive Treatment Of Microbial Resistancementioning

confidence: 99%

Quorum-Sensing Regulation of Antimicrobial Resistance in Bacteria

2020

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“…Natural products have been extensively studied-at first in order to find agents that could inhibit growth of pathogenic microorganisms, but recently attention is focused on the role of natural products as inhibitors of virulence and quorum quenching agents [10]. Biological activities of numerous medicinal plants and foods are linked to abundant presence of flavonoids as bioactive principles.…”

Section: Introductionmentioning

confidence: 99%

Flavones, Flavonols, and Glycosylated Derivatives—Impact on Candida albicans Growth and Virulence, Expression of CDR1 and ERG11, Cytotoxicity

Ivanov

Kannan²,

Stojković

et al. 2020

Pharmaceuticals

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Due to the high incidence of fungal infections worldwide, there is an increasing demand for the development of novel therapeutic approaches. A wide range of natural products has been extensively studied, with considerable focus on flavonoids. The antifungal capacity of selected flavones (luteolin, apigenin), flavonols (quercetin), and their glycosylated derivatives (quercitrin, isoquercitrin, rutin, and apigetrin) along with their impact on genes encoding efflux pumps (CDR1) and ergosterol biosynthesis enzyme (ERG11) has been the subject of this study. Cytotoxicity of flavonoids towards primary liver cells has also been addressed. Luteolin, quercitrin, isoquercitrin, and rutin inhibited growth of Candida albicans with the minimal inhibitory concentration of 37.5 µg/mL. The application of isoquercitrin has reduced C. albicans biofilm establishing capacities for 76%, and hyphal formation by yeast. In vitro treatment with apigenin, apigetrin, and quercitrin has downregulated CDR1. Contrary to rutin and apigenin, isoquercitrin has upregulated ERG11. Except apigetrin and quercitrin (90 µg/mL and 73 µg/mL, respectively inhibited 50% of the net cell growth), the examined flavonoids did not exhibit cytotoxicity. The reduction of both fungal virulence and expression of antifungal resistance-linked genes was the most pronounced for apigenin and apigetrin; these results indicate flavonoids’ indispensable capacity for further development as part of an anticandidal therapy or prevention strategy.

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“…Quorum sensing (QS) was an important discovery in the field of microbiology related to the social behavior of bacteria. QS is defined as environmental signal sensing system to monitor population density of bacterial, and regulate a set of bacterial behaviors including bioluminescence, biofilm formation, virulence, swarming motility, competence, antibiotic production, conjugation, and sporulation [ 6 ]. Many pathogenic bacteria, including Escherichia coli O157: H7, Pseudomonas aeruginosa , Vibrio cholerae , and Salmonella enterica can produce a kind of signal molecule, Acyl hyperserine lactone (AHL), which was named autoinducer type 1 (AI-1), and many phenotypes of them are controlled by this type 1 QS.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, biofilms allow bacteria to resist a variety of extreme environments, including antibacterial substances, high temperature, high salt, and drying [ 10 , 11 ]. Biofilms are therefore novel targets for certain antimicrobial agents [ 1 , 6 ]. Due to their anti-QS activities, quorum-sensing inhibitors (QSIs) can eliminate bacterial pathogenicity or enhance their sensitivity to antibiotics without killing microorganisms, and do not lead to bacteria resistance [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…Recent researches have focused on the development of AHL analogues as QSIs [ 14 ], and many types of QSIs have been reported. Small molecule compounds extracted from plants have attracted significant interest because of their safety and non-toxicity [ 6 , 15 ]. Previous studies on plant polyphenols and flavonoids, such as quercetin, apigenin, and kaempferol, have predominantly concentrated on their antioxidant, anti-inflammatory, and anticancer activities [ 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Ethanol Extract of Campsis grandiflora Flower and Its Organic Acid Components Have Inhibitory Effects on Autoinducer Type 1 Quorum Sensing

et al. 2020

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Chinese herbs are a useful resource bank for natural drug development, and have attracted considerable attention to exploit quorum sensing inhibitors (QSIs). This study was designed to screen QSIs from raw Chinese herb materials. Of the 38 common herbs examined, the ethanol extract of Campsis grandiflora flower had the strongest QSI activity. The C. grandiflora flower ethanol extract (CFEE) was purified by HPD600, and the QSI activities were examined in further detail. CFEE inhibited violacein production of Chromobacterium violaceum 026 in a dose-dependent manner, and inhibit the swarming abilities of Escherichia coli K-12 and Pseudomonas aeruginosa PAO1. Furthermore, CFEE could inhibited biofilm formation and destroyed mature biofilms of E. coli K-12 and P. aeruginosa PAO1. The composition of CFEE was determined by UPLC-MS/MS to distinguish active QSI compounds, and 21 compounds were identified. In addition to gallic acid and caffeic acid, two organic acids, malic acid and succinic acid, were confirmed for the first time to have autoinducer type 1 QSI activities. Therefore, CFEE is a potential QSI that could be used as a novel antimicrobial agent and should be considered for medicinal development.

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Natural products as biofilm formation antagonists and regulators of quorum sensing functions: A comprehensive review update and future trends

Cited by 47 publications

References 137 publications

Quorum-Sensing Regulation of Antimicrobial Resistance in Bacteria

Quorum-Sensing Regulation of Antimicrobial Resistance in Bacteria

Flavones, Flavonols, and Glycosylated Derivatives—Impact on Candida albicans Growth and Virulence, Expression of CDR1 and ERG11, Cytotoxicity

Ethanol Extract of Campsis grandiflora Flower and Its Organic Acid Components Have Inhibitory Effects on Autoinducer Type 1 Quorum Sensing

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