Natural Products as a Novel Therapeutic Strategy for NLRP3 Inflammasome-Mediated Gout

Lee, Jun Ho; Kim, Hyuk Soon; Lee, Jun-Ho; Yang, Gabsik; Kim, Hong Jun

doi:10.3389/fphar.2022.861399

Cited by 4 publications

(2 citation statements)

References 55 publications

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“…A wide range of PAMPs and DAMPs that disrupt cellular hemostasis can be detected by NLRP3 (Liston & Masters, 2017). In recent years, copious shreds of evidence have shown the association between damaging inflammation related to NLRP3 and different diseases such as multiple sclerosis (Cui et al, 2022, Yi, 2021), Alzheimer's disease (Heneka et al, 2013; Merighi et al, 2022), psoriasis (Ciążyńska et al, 2021), gout (J. H. Lee et al, 2022; Zhong et al, 2022), and autoinflammatory conditions (Caseley et al, 2022; Nakanishi et al, 2022; Zhou et al, 2022). As mentioned earlier, there are several pieces of evidence that show the pivotal roles of NLRP3 inflammasome in the immunopathogenesis of KD.…”

Section: Introductionmentioning

confidence: 99%

Potential roles of NLRP3 inflammasome in the pathogenesis of Kawasaki disease

Shahi

Afzali

Firoozi

et al. 2023

Journal Cellular Physiology

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There is a heterogeneous group of rare illnesses that fall into the vasculitis category and are characterized mostly by blood vessel inflammation. Ischemia and disrupted blood flow will cause harm to the organs whose blood arteries become inflamed. Kawasaki disease (KD) is the most prevalent kind of vasculitis in children aged 5 years or younger. Because KD's cardiovascular problems might persist into adulthood, it is no longer thought of as a self‐limiting disease. KD is a systemic vasculitis with unknown initiating factors. Numerous factors, such as genetic predisposition and infectious pathogens, are implicated in the etiology of KD. As endothelial cell damage and inflammation can lead to coronary endothelial dysfunction in KD, some studies hypothesized the crucial role of pyroptosis in the pathogenesis of KD. Additionally, pyroptosis‐related proteins like caspase‐1, apoptosis‐associated speck‐like protein containing a CARD (ASC), proinflammatory cytokines like IL‐1 and IL‐18, lactic dehydrogenase, and Gasdermin D (GSDMD) have been found to be overexpressed in KD patients when compared to healthy controls. These occurrences may point to an involvement of inflammasomes and pyroptotic cell death in the etiology of KD and suggest potential treatment targets. Based on these shreds of evidence, in this review, we aim to focus on one of the well‐defined inflammasomes, NLRP3, and its role in the pathophysiology of KD.

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Section: Introductionmentioning

confidence: 99%

Potential roles of NLRP3 inflammasome in the pathogenesis of Kawasaki disease

Shahi

Afzali

Firoozi

et al. 2023

Journal Cellular Physiology

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“…Of all the inflammasomes, NOD‐like receptor protein‐3 (NLRP3) inflammasome is the most extensively studied and described. The NLRP3 inflammasome has been implicated in the development of various inflammatory diseases, including type 2 diabetes (Rovira‐Llopis et al, 2018), Alzheimer's disease (Feng et al, 2020), cardiovascular disease (D. Liu et al, 2018; Marin‐Aguilar et al, 2020), and gout (Lee et al, 2022), suggesting that it may be a potential target for anti‐inflammatory treatment. Both clinical and laboratory data suggest that the NLRP3 inflammasome plays an important role in the progression of hypertensive TOD (D. Liu et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Targeting the NLRP3 inflammasome for the treatment of hypertensive target organ damage: Role of natural products and formulations

Liao,

Han,

Shen

et al. 2023

Phytotherapy Research

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Background and AimHypertension is a major global health problem that causes target organ damage (TOD) in the heart, brain, kidney, and blood vessels. The mechanisms of hypertensive TOD are not fully understood, and its treatment is challenging. This review provides an overview of the current knowledge on the role of Nod‐like receptor pyrin domain containing 3 (NLRP3) inflammasome in hypertensive TOD and the natural products and formulations that inhibit it.MethodsWe searched PubMed, Web of Science, Google Scholar, and CNKI for relevant articles using the keywords “hypertension,” “target organ damage,” “NLRP3 inflammasome,” “natural products,” and “formulations.” We reviewed the effects of the NLRP3 inflammasome on hypertensive TOD in different organs and discussed the natural products and formulations that modulate it.Key resultsIn hypertensive TOD, the NLRP3 inflammasome is activated by various stimuli such as oxidative stress and inflammation. Activation of NLRP3 inflammasome leads to the production of pro‐inflammatory cytokines that exacerbate tissue damage and dysfunction. Natural products and formulations, including curcumin, resveratrol, triptolide, and allicin, have shown protective effects against hypertensive TOD by inhibiting the NLRP3 inflammasome.Conclusions and ImplicationsThe NLRP3 inflammasome is a promising therapeutic target in hypertensive TOD. Natural products and formulations that inhibit the NLRP3 inflammasome may provide novel drug candidates or therapies for hypertensive TOD. Further studies are needed to elucidate the molecular mechanisms and optimize the dosages of these natural products and formulations and evaluate their clinical efficacy and safety.

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The alleviatory effects of koumine on MSU‐induced gouty arthritis via the TLR4/NF‐κB/NLRP3 pathway

Lin,

Chen,

Zhan

et al. 2024

Basic Clin Pharma Tox

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The aim of this study was to validate the preventive effects of koumine (KM), a monoterpene indole alkaloid, on gouty arthritis (GA) and to explore its possible mechanisms. C57BL/6 mice were intraperitoneally administered KM (0.8, 2.4 or 7.2 mg/kg), colchicine (3.0 mg/kg) or sterile saline. One hour later, a monosodium urate (MSU) suspension was injected into the right hind paws of the mice to establish an acute gout model. Inflammation symptoms were evaluated at 0, 3, 6, 12 and 24 h, and the mechanical withdrawal threshold was evaluated at 0, 6 and 24 h. After 24 h, the mice were euthanized, and the joint tissue, kidney and blood were collected for subsequent experiments. Histological examination and antioxidant enzyme, kidney index and serum uric acid (UA) measurements were taken. The expression levels of the signalling pathway components were determined. KM effectively alleviated the symptoms of redness, swelling and pain; counteracted inflammatory cell infiltration; and increased antioxidant enzyme levels, reduced kidney index and seru UA levels through regulating UA excretion in MSU‐induced mice. The expression of toll‐like receptor 4 (TLR4)/nuclear factor kappa‐B (NF‐κB)/nucleotide‐binding oligomerization domain, leucine‐rich repeat and pyrin domain‐containing 3 (NLRP3) signalling pathway proteins and mRNA were reduced in the KM group. These results suggest that KM may be effective in alleviating GA through the TLR4/NF‐κB/NLRP3 pathway.

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Natural Products as a Novel Therapeutic Strategy for NLRP3 Inflammasome-Mediated Gout

Cited by 4 publications

References 55 publications

Potential roles of NLRP3 inflammasome in the pathogenesis of Kawasaki disease

Potential roles of NLRP3 inflammasome in the pathogenesis of Kawasaki disease

Targeting the NLRP3 inflammasome for the treatment of hypertensive target organ damage: Role of natural products and formulations

The alleviatory effects of koumine on MSU‐induced gouty arthritis via the TLR4/NF‐κB/NLRP3 pathway

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