Natural products and analogs as preventive agents for metabolic syndrome via peroxisome proliferator-activated receptors: An overview

Villarroel-Vicente, Carlos; Gutiérrez-Palomo, Sergio; Ferri, Jordi; Cortés, Diego; Cabedo, Nuria

doi:10.1016/j.ejmech.2021.113535

Cited by 38 publications

(30 citation statements)

References 193 publications

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“…compounds account for a large proportion [64][65][66][67][68][69]. The second apart of this review describes the bioactive components contained in unripe fruits, which occur at higher concentrations than mature fruits.…”

Section: "High Added Value" Of Bioactive Components From Thinned Unripe Fruitsmentioning

confidence: 99%

“…Many studies reported that the inclusion of more fruits in the diet is good for our health because it may reduce the chance of many chronic diseases, such as cardiovascular disease, cancer, obesity and diabetes (Figure 3) [62,63]. These beneficial effects are attributed to the fact that fruits contain several phytochemical components, and phenolic compounds account for a large proportion [64][65][66][67][68][69]. The second apart of this review describes the bioactive components contained in unripe fruits, which occur at higher concentrations than mature fruits.…”

Section: "High Added Value" Of Bioactive Components From Thinned Unripe Fruitsmentioning

confidence: 99%

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Comprehensive Utilization of Thinned Unripe Fruits from Horticultural Crops

Wei

Wang

et al. 2021

Foods

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Fruit thinning is a cultivation technique that is widely applied in horticulture in order to obtain high-quality horticultural crops. This practice results in the discarding of a large number of thinned unripe fruits in orchards each year, which produces a great waste of agricultural resources and causes soil pollution that may be an important reservoir for pest and plant diseases. Current studies showed that bioactive compounds such as polyphenols, organic acids, monosaccharides and starches are present in unripe fruits. Therefore, we reviewed the bioactive components obtained from thinned unripe fruits, their revalorization for the food industry, their beneficial effects for human health and the methods for obtaining these components. We also performed a calculation of the costs and benefits of obtaining these bioactive compounds, and we proposed future research directions. This review provides a reference for the effective utilization and industrial development of thinned unripe fruits obtained from horticultural crops. Furthermore, revalorizing the waste from this cultural practice may increase the economic benefits and relieve the environmental stress.

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Section: "High Added Value" Of Bioactive Components From Thinned Unripe Fruitsmentioning

confidence: 99%

Section: "High Added Value" Of Bioactive Components From Thinned Unripe Fruitsmentioning

confidence: 99%

Comprehensive Utilization of Thinned Unripe Fruits from Horticultural Crops

Wei

Wang

et al. 2021

Foods

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“…In this study, we propose the antihypertensive drug TLM as a putative new therapeutic approach for treating diseases characterized by myelin dysfunctions by virtue of its unique activity among the members of the Sartans family as a PPAR-γ selective modulator [58,59]. The study uses a "drug repositioning" approach to identify a new therapeutic indication for a drug already in clinical use.…”

Section: Discussionmentioning

confidence: 99%

The Antihypertensive Drug Telmisartan Protects Oligodendrocytes from Cholesterol Accumulation and Promotes Differentiation by a PPAR-γ-Mediated Mechanism

Bernardo

Malara

Bertuccini

et al. 2021

IJMS

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Our previous studies have demonstrated that specific peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists play a fundamental role in oligodendrocyte progenitor (OP) differentiation, protecting them against oxidative and inflammatory damage. The antihypertensive drug Telmisartan (TLM) was shown to act as a PPAR-γ modulator. This study investigates the TLM effect on OP differentiation and validates its capability to restore damage in a pharmacological model of Niemann-Pick type C (NPC) disease through a PPAR-γ-mediated mechanism. For the first time in purified OPs, we demonstrate that TLM-induced PPAR-γ activation downregulates the type 1 angiotensin II receptor (AT1), the level of which naturally decreases during differentiation. Like other PPAR-γ agonists, we show that TLM promotes peroxisomal proliferation and promotes OP differentiation. Furthermore, TLM can offset the OP maturation arrest induced by a lysosomal cholesterol transport inhibitor (U18666A), which reproduces an NPC1-like phenotype. In the NPC1 model, TLM also reduces cholesterol accumulation within peroxisomal and lysosomal compartments and the contacts between lysosomes and peroxisomes, revealing that TLM can regulate intracellular cholesterol transport, crucial for myelin formation. Altogether, these data indicate a new potential use of TLM in hypomyelination pathologies such as NPC1, underlining the possible repositioning of the drug already used in other pathologies.

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“…This point is underscored by the fact that drugs such as the thiazolidinediones (TZDs), which stimulate adipogenesis via PPARg activation, are potent insulin sensitizers (56). Since TZDs have fallen out of use in recent years due to significant side effects, efforts are ongoing to identify natural product partial agonists of PPARg to combat metabolic syndrome (57)(58)(59)(60). Researchers investigating SCOPA in adipocytes have employed these alternate strategies (inhibition or promotion of adipogenesis) and have therefore focused on different bioactivities in SCOPA.…”

Section: Effects Of a Scoparia On Determinants Of Metabolic Health Me...mentioning

confidence: 99%

Artemisia scoparia and Metabolic Health: Untapped Potential of an Ancient Remedy for Modern Use

et al. 2022

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Botanicals have a long history of medicinal use for a multitude of ailments, and many modern pharmaceuticals were originally isolated from plants or derived from phytochemicals. Among these, artemisinin, first isolated from Artemisia annua, is the foundation for standard anti-malarial therapies. Plants of the genus Artemisia are among the most common herbal remedies across Asia and Central Europe. The species Artemisia scoparia (SCOPA) is widely used in traditional folk medicine for various liver diseases and inflammatory conditions, as well as for infections, fever, pain, cancer, and diabetes. Modern in vivo and in vitro studies have now investigated SCOPA’s effects on these pathologies and its ability to mitigate hepatotoxicity, oxidative stress, obesity, diabetes, and other disease states. This review focuses on the effects of SCOPA that are particularly relevant to metabolic health. Indeed, in recent years, an ethanolic extract of SCOPA has been shown to enhance differentiation of cultured adipocytes and to share some properties of thiazolidinediones (TZDs), a class of insulin-sensitizing agonists of the adipogenic transcription factor PPARγ. In a mouse model of diet-induced obesity, SCOPA diet supplementation lowered fasting insulin and glucose levels, while inducing metabolically favorable changes in adipose tissue and liver. These observations are consistent with many lines of evidence from various tissues and cell types known to contribute to metabolic homeostasis, including immune cells, hepatocytes, and pancreatic beta-cells. Compounds belonging to several classes of phytochemicals have been implicated in these effects, and we provide an overview of these bioactives. The ongoing global epidemics of obesity and metabolic disease clearly require novel therapeutic approaches. While the mechanisms involved in SCOPA’s effects on metabolic, anti-inflammatory, and oxidative stress pathways are not fully characterized, current data support further investigation of this plant and its bioactives as potential therapeutic agents in obesity-related metabolic dysfunction and many other conditions.

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Natural products and analogs as preventive agents for metabolic syndrome via peroxisome proliferator-activated receptors: An overview

Cited by 38 publications

References 193 publications

Comprehensive Utilization of Thinned Unripe Fruits from Horticultural Crops

Comprehensive Utilization of Thinned Unripe Fruits from Horticultural Crops

The Antihypertensive Drug Telmisartan Protects Oligodendrocytes from Cholesterol Accumulation and Promotes Differentiation by a PPAR-γ-Mediated Mechanism

Artemisia scoparia and Metabolic Health: Untapped Potential of an Ancient Remedy for Modern Use

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