Natural products: a strategic lead generation approach in crop protection discovery

Lorsbach, Beth A.; Sparks, Thomas C.; Cicchillo, Robert M.; Garizi, Negar V; Hahn, Donald R.; Meyer, Kevin G.

doi:10.1002/ps.5350

Cited by 66 publications

(60 citation statements)

References 55 publications

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“…Different approaches adopted to overcome the negative impacts of overuse of pesticides include precision agriculture [ 11 ], biopesticides [ 6 , 12 ], encapsulating agents [ 13 ], and seed coatings [ 14 ]. Precision agriculture deals with the utilization of various in-field, near-range, and remote sensing techniques to identify problem areas that may need timely intervention [ 11 ], whereas biopesticides are naturally occurring substances that control pests via predatory, parasitic, or chemical relationships [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Recent advances in biodegradable matrices for active ingredient release in crop protection: Towards attaining sustainability in agriculture

Pirzada

Farias

Mathew

et al. 2020

Current Opinion in Colloid & Interface Science

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Climate changes, emerging species of plant pests, and deficits of clean water and arable land have made availability of food to the ever-increasing global population a challenge. Excessive use of synthetic pesticides to meet ever-increasing production needs has resulted in development of resistance in pest populations, as well as significant ecotoxicity, which has directly and indirectly impacted all life-forms on earth. To meet the goal of providing safe, sufficient, and high-quality food globally with minimal environmental impact, one strategy is to focus on targeted delivery of pesticides using eco-friendly and biodegradable carriers that are derived from naturally available materials. Herein, we discuss some of the recent approaches to use biodegradable matrices in crop protection, while exploring their design and efficiency. We summarize by discussing associated challenges with the existing approaches and future trends that can lead the world to more sustainable agricultural practices.

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Section: Introductionmentioning

confidence: 99%

Recent advances in biodegradable matrices for active ingredient release in crop protection: Towards attaining sustainability in agriculture

Pirzada

Farias

Mathew

et al. 2020

Current Opinion in Colloid & Interface Science

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“…Natural products, with their enormous structural diversity, are an invaluable source of inspiration in the design and development of new biologically active compounds [ 3 ]. Having evolved over several millennia to acquire specific ligand–protein binding motifs, these privileged compounds serve as important, biologically pre-validated platforms for the development of new leads in medicinal chemistry and agriculture.…”

Section: Introductionmentioning

confidence: 99%

Natural Compound-Derived Cytochrome bc1 Complex Inhibitors as Antifungal Agents

2020

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The high incidence of fungal pathogens has become a global issue for crop protection. A promising strategy to control fungal plant infections is based on the use of nature-inspired compounds. The cytochrome bc1 complex is an essential component of the cellular respiratory chain and is one of the most important fungicidal targets. Natural products have played a crucial role in the discovery of cytochrome bc1 inhibitors, as proven by the development of strobilurins, one of the most important classes of crop-protection agents, over the past two decades. In this review, we summarize advances in the exploration of natural product scaffolds for the design and development of new bc1 complex inhibitors. Particular emphasis is given to molecular modeling-based approaches and structure–activity relationship (SAR) studies performed to improve the stability and increase the potency of natural precursors. The collected results highlight the versatility of natural compounds and provide an insight into the potential development of nature-inspired derivatives as antifungal agents.

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“…Although there are many techniques and technologies, including biological control, transgenic plants, and host plant resistance, pesticides remain a vital component for pest insect control. 1 A large proportion of commercially available insecticides are chemical pesticides, and pest control measures nowadays rely heavily on them. For example, the chemical insecticides applied on Helicoverpa zea, a significant pest on crops in the agricultural regions worldwide, 2 have been tested, modified, and used for approximately 70 years, 3 but field testing has shown that some chemical insecticides generally offer only limited control of H. zea.…”

Section: Introductionmentioning

confidence: 99%

Isochamaejasmin induces toxic effects onHelicoverpa zeaviaDNAdamage and mitochondria‐associated apoptosis

Ren

et al. 2020

Pest Management Science

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BACKGROUND: Stellera chamaejasme L. is a poisonous plant with rich resources and is thus highly valuable in terms of new pesticide development. Isochamaejasmin (ICM), one of the main ingredients in S. chamaejasme has drawn much attention owing to its antitumour properties. However, the toxicity and mode of action of ICM on insects are still not clear. In this article, the larva and neuronal cell (AW1) of Helicoverpa zea were used to clarify the insecticidal activity of ICM as well as its toxic mechanism at the cellular level. RESULTS: The results confirmed that ICM has potential toxicity against H. zea both in vivo and in vitro via time-and dosedependent manners. Moreover, we found that ICM caused DNA damage and increased the levels of γH2AX and OGG1 in AW1 cells. Results also showed decline in the mitochondrial membrane potential (MMP), upregulation of Bax/Bcl-2 expression resulting in the release of cytochrome c into the cytosol, activation of caspase-3/9, and cleavage of poly ADP-ribose polymerase (PARP) as a result of exposure to ICM. Additionally, a dose-dependent rise in the reactive oxygen species (ROS) levels, accumulation of a lipid peroxidation product, and inactivation of antioxidant enzymes were found in ICM-treated cells. CONCLUSION: These findings confirmed the insecticidal activity of ICM. Furthermore, the results revealed that ICM could cause DNA damage and induce apoptosis via the mitochondrial pathway in AW1 cells. This study provides the basic information needed to understand the toxicity and mechanisms of action of ICM, which could potentially be used to develop it as a new insecticide.

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Natural products: a strategic lead generation approach in crop protection discovery

Cited by 66 publications

References 55 publications

Recent advances in biodegradable matrices for active ingredient release in crop protection: Towards attaining sustainability in agriculture

Recent advances in biodegradable matrices for active ingredient release in crop protection: Towards attaining sustainability in agriculture

Natural Compound-Derived Cytochrome bc1 Complex Inhibitors as Antifungal Agents

Isochamaejasmin induces toxic effects onHelicoverpa zeaviaDNAdamage and mitochondria‐associated apoptosis

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