Natural products: A safest approach for obesity

Vasudeva, Neeru; Yadav, Neerja; Sharma, Surendra Kumar

doi:10.1007/s11655-012-1120-0

Cited by 59 publications

(60 citation statements)

References 43 publications

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“…5) Numerous trials have been conducted to discover pharmacological features of crude plant extracts, isolates, and phytochemical combinations against obesity. 6,7) Nevertheless, attention has continuously focused on new anti-obesity agents from herbal resources to minimize adverse effects associated with the present anti-obesity drugs. 6) Dioscorea oppositifolia L. (Dioscoreaceae, synonym: D. opposita THUNB.)…”

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confidence: 99%

“…6,7) Nevertheless, attention has continuously focused on new anti-obesity agents from herbal resources to minimize adverse effects associated with the present anti-obesity drugs. 6) Dioscorea oppositifolia L. (Dioscoreaceae, synonym: D. opposita THUNB.) has been cultivated in China, Japan, and Korea as a food and widely used as a traditional medicine for a long time.…”

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confidence: 99%

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Anti-obesity Effect of <i>Dioscorea oppositifolia</i> Extract in High-Fat Diet-Induced Obese Mice and Its Chemical Characterization

Jeong

Jegal

Ahn

et al. 2016

Biological & Pharmaceutical Bulletin

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Dioscorea oppositifolia is a well-known edible and traditional medicine for the treatment of gastrointestinal diseases. In our previous study, D. oppositifolia exhibited both pancreatic lipase inhibition and an anti-adipogenesis effect in vitro. This study was performed to investigate the anti-obesity effect of D. oppositifolia on high-fat diet-induced obese mice. Female ICR mice were fed a high-fat diet with the 100 mg/ kg of D. oppositifolia n-BuOH extract for 8 weeks. The high-fat diet mice received the 15 mg/kg Orlistat orally as a positive control. The body weight, parametrial adipose tissue weight, and the levels of triglyceride (TG), total cholesterol (TC), and low density lipoprotein (LDL)-cholesterol in blood serum of female ICR mice were significantly decreased by feeding a high-fat diet with the n-BuOH extract of D. oppositifolia. An inhibitory effect of D. oppositifolia extract on dietary fat absorption was also clearly shown. The D. oppositifolia sample was found to contain 3,5-dimethoxy-2,7-phenanthrenediol and (3R,5R)-3,5-dihydroxy-1,7-bis(4-hydroxyphenyl)-3,5-heptanediol as main components based on its phytochemical analysis. The present study is the first report of the anti-obesity effect by D. oppositifolia n-BuOH extract using an established disease model. The increase in fecal fat excretion by treatment of D. oppositifolia may be an effective approach for treating obesity and related diseases.Key words Dioscorea oppositifolia; anti-obesity; high-fat diet-induced obese mouse; fecal fat excretion; phytochemical analysis Obesity is the disease associated with accumulation of excessive body fat resulting from energy imbalance.1) The obesity epidemic has become a public health problem, leading to secondary chronic diseases like dyslipidemia, cardiovascular disease, and type 2 diabetes.2,3) Furthermore, obese persons experience a number of physical problems such as sleep apnoea and joint pain, which shortens the life expectancy and impacts on the quality of life. 4) Natural phytochemicals have become more attractive as sources of industrial and medicinal materials in overweight and obese patients due to potential anti-obesity properties.5) Numerous trials have been conducted to discover pharmacological features of crude plant extracts, isolates, and phytochemical combinations against obesity. 6,7)Nevertheless, attention has continuously focused on new anti-obesity agents from herbal resources to minimize adverse effects associated with the present anti-obesity drugs. 6)Dioscorea oppositifolia L. (Dioscoreaceae, synonym: D. opposita THUNB.) has been cultivated in China, Japan, and Korea as a food and widely used as a traditional medicine for a long time. Our current pharmacological studies showed that D. oppositifolia possesses significant inhibitory activity against porcine pancreatic lipase in vitro. 8) In addition, the anti-adipogenesis effect of D. oppositifolia n-BuOH soluble extract has been detected in cultured 3T3-L1 adipocyte. 9)Biological activities of Dioscorea species against diverse met...

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confidence: 99%

Anti-obesity Effect of <i>Dioscorea oppositifolia</i> Extract in High-Fat Diet-Induced Obese Mice and Its Chemical Characterization

Jeong

Jegal

Ahn

et al. 2016

Biological & Pharmaceutical Bulletin

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“…Apart from the high amounts of mono and polyunsaturated fatty acids in it, presence of bioactive molecules including plant sterols, essential amino acids, micronutrients and phytochemicals such as resveratrol, IP 6 , coumaric acid, dehydrated quercetin are appreciable [14]. As whole or individual phytoconstituents they directly or indirectly mitigate dyslipidaemia [15], obesity [16,17] and modify postprandial oxidative stress [18].…”

Section: Introductionmentioning

confidence: 99%

“…IP 6 otherwise known as phytate or phytic acid [19] exhibits potential therapeutic action on diabetes mellitus [20], urolithiasis [21], dental caries [22] and a whole range of cancers [23]. However, there are scanty studies on the role of IP 6 in peanuts on adipogenesis till date. In the present study the quantity of IP 6 in raw, boiled and roasted peanuts was measured using HPLC and the possible mechanism of action of IP 6 on adipocyte differentiation was studied by invitro and in-silico analysis.…”

Section: Introductionmentioning

confidence: 99%

Adipogenesis in Obesity is Modulated by IP6 in Peanuts through Activation of the Nuclear Receptors (PPARs)

Malarvizhi¹,

Vk²,

Kumari³

et al. 2016

Journal of Obesity and Overweight

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“…Traditional medicinal plants are often cheaper, locally available and easily consumable, raw or as simple medicinal preparations. Nowadays, traditional medicinal practices form an integral part of complementary or alternative medicine (Vasudeva et al, 2012). Although their efficacy and mechanisms of action have not been tested scientifically in most cases, these simple medicinal preparations often mediate beneficial responses due to their active chemical constituents .…”

Section: Introductionmentioning

confidence: 99%

Phytochemical investigation and radical scavenging activities ofMelia azedarachand its DNA protective effect in cultured lymphocytes

Srinivasan¹,

Balakrishnan²,

Nair³

2013

Pharmaceutical Biology

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Context: Melia azedarach Linn (Meliaceae) is an Ayurvedic medicinal plant which is native to India. It is traditionally used for the treatment of leprosy, inflammation, scrofula, anthelmintic, antilithic, diuretic, deobstruent and cardiac disorders. Objective: To evaluate the phytochemical constituents and antioxidant activities of the ethanol leaf extract of Melia azedarach (MA) and its protective effect against H 2 O 2 -induced cellular damage in cultured lymphocytes. Materials and methods:The dose-dependent study of MA (20, 40, 60, 80, 100 mg/ml) was used to study in vitro radical scavenging assays. The effective dose of MA (60 mg/ml) was further used to study the H 2 O 2 -induced DNA damage (comet assay and DNA fragmentation assay) in cultured lymphocytes. Results: The ethanol extract of MA (20, 40, 60, 80, 100 mg/ml) exhibited a significant dosedependent inhibition of in vitro radical scavenging assays and their corresponding IC 50 values as follows: hydroxyl radical (26.50 AE 0.26 mg/ml), superoxide anion (30.00 AE 0.32 mg/ml), nitric oxide radical (48.00 AE 0.48 mg/ml), DPPH radical (30.55 AE 0.32 mg/ml) and reducing power (22.00 AE 0.22 mg/ml). The increase in the severity of DNA damage and TBARS was increased significantly (p50.05) at 500 mM H 2 O 2 -treated cultured lymphocytes and RBC cellular membranes. The phytochemical screening studies identified 13 chemical constituents present in the leaf extract of MA. Discussion and conclusion: The results of this study demonstrate that MA offers protection against H 2 O 2 -induced cellular damage and it can be developed as an effective antioxidant during oxidative stress.

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Natural products: A safest approach for obesity

Cited by 59 publications

References 43 publications

Anti-obesity Effect of <i>Dioscorea oppositifolia</i> Extract in High-Fat Diet-Induced Obese Mice and Its Chemical Characterization

Anti-obesity Effect of <i>Dioscorea oppositifolia</i> Extract in High-Fat Diet-Induced Obese Mice and Its Chemical Characterization

Adipogenesis in Obesity is Modulated by IP6 in Peanuts through Activation of the Nuclear Receptors (PPARs)

Phytochemical investigation and radical scavenging activities ofMelia azedarachand its DNA protective effect in cultured lymphocytes

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