Natural Product Inhibitors of Histone Deacetylases as New Anticancer Agents

Hanikoğlu, Aysegul; Hanikoglu, Ferhat; Özben, Tomris

doi:10.2174/1389203718666170106101133

Cited by 12 publications

(11 citation statements)

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“…Isolated from the fungus Streptomyces hygroscopicus in 1976 by Tsuji et al., is a classic linear hydroxamic acid derivative and one of the first natural product determined to have HDAC inhibitory activity . Because it is one of the most potent known HDAC inhibitors, with nanomolar inhibition of recombinant HDAC 1 and 6, trichostatin A (TSA) is routinely used as a positive control and as a reference to compare other HDACi ,. TSA has been reported to inhibit cell growth in, among others, lung adenocarcinoma, hepatoma, cervix carcinoma, and small cell lung cancer, through regulation P21 waf/cip1 , P27 , Bcl‐Xl , cyclin A and E, etc ,.…”

Section: Histone Deacetylase‐modulating Natural Productsmentioning

confidence: 99%

Natural Products and Chemical Biology Tools: Alternatives to Target Epigenetic Mechanisms in Cancers

Lascano

Lopez

Arimondo

2018

The Chemical Record

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DNA methylation and histone acetylation are widely studied epigenetic modifications. They are involved in numerous pathologies such as cancer, neurological disease, inflammation, obesity, etc. Since the discovery of the epigenome, numerous compounds have been developed to reverse DNA methylation and histone acetylation aberrant profile in diseases. Among them several were inspired by Nature and have a great interest as therapeutic molecules. In the quest of finding new ways to target epigenetic mechanisms, the use of chemical tools is a powerful strategy to better understand epigenetic mechanisms in biological systems. In this review we will present natural products reported as DNMT or HDAC inhibitors for anticancer treatments. We will then discuss the use of chemical tools that have been used in order to explore the epigenome.

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Section: Histone Deacetylase‐modulating Natural Productsmentioning

confidence: 99%

Natural Products and Chemical Biology Tools: Alternatives to Target Epigenetic Mechanisms in Cancers

Lascano

Lopez

Arimondo

2018

The Chemical Record

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“…Given the extensive research on the special structure, substrate, and biological function of HDAC6, it could be considered as an important potential therapeutic target for numerous diseases, including cancer ( Lee et al, 2008 ), neurodegenerative disease ( Krukowski et al, 2017 ), and inflammatory diseases ( Yan et al, 2018 ). Furthermore, HDAC6 inhibitors have been widely investigated, with some being found to act effectively with antitumor agents or other drugs ( Li et al, 2017 ; Hanikoglu et al, 2018 ). For example, colorectal and breast cancer cells are inhibited through treatment with a combination of thiol-based inhibitors and paclitaxel ( Itoh et al, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Role of HDAC6 and Its Selective Inhibitors in Gastrointestinal Cancer

Zhou

Liu

Tan

2021

Front. Cell Dev. Biol.

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Worldwide, cancer is the second leading cause of mortality after cardiovascular diseases. Among the numerous malignant tumors in human, digestive system cancers are the primary cause of morbidity and mortality. Acetylation and deacetylation are crucially involved in cancer occurrence and development; in addition, the deacetylation process is regulated by histone deacetylases (HDACs). Among the 18 human HDACs that have been reported, HDAC6 has been widely studied. There is upregulated HDAC6 expression in numerous types of tumor tissues and is closely associated with clinicopathological characteristics. Moreover, several HDAC6 inhibitors have been identified; furthermore, there has been extensive research on their ability to inhibit the growth of many tumors. This review summarizes the roles of HDAC6 in different primary digestive system malignancies.

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“…Valproate has the advantage that it is already approved for some clinical applications. In addition to some carboxylic acids there are a variety of structures that are histone deacetylase inhibitors and these include some naturally occurring molecules [7,8]. One objective of the present work was to compare the action of different structural classes of histone deacetylase inhibitors as inducers of enzyme activity in bladder and colon cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Variability in the induction of alkaline phosphatase by histone deacetylase inhibitors in bladder and colon cancer cell lines

Ma¹,

Batista²,

L³

et al. 2019

J Cancer Res Ther.

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Induction of alkaline phosphatase activity has provided a convenient marker for differentiation of colon cancer cells. The degree to which different histone deacetylase inhibitors induce alkaline phosphatase and dipeptidyl peptidase activities was compared in bladder and colon cancer cell lines. The objective was to determine whether bladder cancer cell lines that retain activities of the cell surface hydrolases exhibit regulatory effects similar to those previously observed in colon cancer cells. Effects of histone deacetylase inhibitors on growth and alkaline phosphatase and dipeptidyl peptidase activities were studied in three human colon cancer cells and three bladder cancer cell lines. Growth inhibition was observed with all the histone deacetylase inhibitors that were examined. There was variability in the induction of enzyme activity with different histone deacetylase inhibitors but when induction was observed it was greater for alkaline phosphatase than for dipeptidyl peptidase. The data suggested that regulation of alkaline phosphatase and dipeptidyl peptidase activities by histone deacetylase inhibitors can be similar in bladder and colon cancer cells. However, the functional role of the enzyme activities in bladderderived cells remains to be established.

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Natural Product Inhibitors of Histone Deacetylases as New Anticancer Agents

Cited by 12 publications

References 0 publications

Natural Products and Chemical Biology Tools: Alternatives to Target Epigenetic Mechanisms in Cancers

Natural Products and Chemical Biology Tools: Alternatives to Target Epigenetic Mechanisms in Cancers

Role of HDAC6 and Its Selective Inhibitors in Gastrointestinal Cancer

Variability in the induction of alkaline phosphatase by histone deacetylase inhibitors in bladder and colon cancer cell lines

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