Natural Product Growth Inhibitors of Mycobacterium tuberculosis

Copp, Brent R.; Pearce, A. Norrie

doi:10.1002/chin.200731222

Cited by 48 publications

(68 citation statements)

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“…Although as complex as its spectrum appeared, we could recognize the presence of benzophenanthridine alkaloids, as well as lignans and linear-chain fatty acids in Zanthoxylum capense CH 2 Cl 2 extract. Since all these three classes of compounds have been well reported to possess antimycobacterial activity (Copp, 2003;Copp and Pearce, 2007), it seems interesting to clarify whether the potent antimycobacterial activity displayed by Zanthoxylum capense CH 2 Cl 2 extract is due to one of these compounds, or whether this activity is due to synergistic effects of some or all of these compounds.…”

Section: Preliminary Phytochemical Investigationmentioning

confidence: 99%

“…Therefore, potent new anti-tubercular drugs with novel modes of action and low toxicity are urgently needed to combat the threat of TB. Natural sources provide numerous examples of interesting secondary metabolites with antimycobacterial activity, indicating that natural products could be rewarding field for the discovery of new anti-TB leads (Newton et al, 2000;Copp, 2003;Pauli et al, 2005;Copp and Pearce, 2007). In Mozambique, where around 500 plant species are used as traditional medicine, people mainly rely on medicinal plants as their primary source for medication.…”

Section: Introductionmentioning

confidence: 99%

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Antimycobacterial evaluation and preliminary phytochemical investigation of selected medicinal plants traditionally used in Mozambique

Luo

Pires

Aínsa

et al. 2011

Journal of Ethnopharmacology

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Aims of the study: It was aimed to assess the in vitro antimycobacterial activity of crude extracts from fifteen medicinal plants and to reveal main classes of compounds which may account for the activity of extracts. Methods and materials:The plant materials were sequentially extracted by n-hexane, dichloromethane, ethyl acetate, and 70% ethanol. Decoction of each plant material was also prepared according to traditional use. Broth microdilution method was employed to screen extracts against two mycobacterial species: Mycobacterium smegmatis ATCC 607 and Mycobacterium tuberculosis H37Rv. The extracts with minimum inhibitory concentration(s) (MIC) below 125 g/mL were considered active and further tested against different mycobacterial species and strains, namely Mycobacterium tuberculosis H37Ra, Mycobacterium bovis BCG ATCC 35734, Mycobacterium smegmatis mc 2 155, Mycobacterium avium DSM 44156 and DSM 44157. Cytotoxic effect was evaluated against human macrophages from the monocytic THP-1 cells. Main classes of compounds in these active extracts were proposed from their 1 H NMR spectroscopic characterizations. Results: n-Hexane extracts of Maerua edulis and Securidaca longepedunculata, ethyl acetate extract of Tabernaemontana elegans and dichloromethane extract of Zanthoxylum capense were found to possess considerable activity against Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Ra with MIC 15.6-62.5 g/mL. Tabernaemontana elegans ethyl acetate extract displayed strong activity against Mycobacterium tuberculosis H37Rv (MIC 15.6 g/mL). Except for Tabernaemontana elegans ethyl acetate extract which presented potent cytotoxic effects in THP-1 cells (IC 50 < 4 g/mL), the other three plant extracts showed moderate to none toxicity. Based on 1 H NMR spectroscopic analysis, major components in both Maerua edulis and Securidaca longepedunculata n-hexane extracts were linear chain unsaturated fatty acids. Zanthoxylum capense dichloromethane extract contained more complex constituents (mostly phenolic compounds). In the most potent extract, Tabernaemontana elegans ethyl acetate extract, the prominent compounds were identified as indole alkaloids. Conclusions: The pronounced antimycobacterial activity of the medicinal plants Maerua edulis, Securidaca longepedunculata, Zanthoxylum capense, and Tabernaemontana elegans suggested that they might provide compounds which could be potential anti-TB drug leads.

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Section: Preliminary Phytochemical Investigationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antimycobacterial evaluation and preliminary phytochemical investigation of selected medicinal plants traditionally used in Mozambique

Luo

Pires

Aínsa

et al. 2011

Journal of Ethnopharmacology

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“…(Copp & Pearce, 2007;Okunade, Elvin-Lewis & Lewis, 2004). The modification of natural triterpenes such as betulinic acid (21), oleanolic acid (22) and ursolic acid (23) through introduction of cinnamoyl frames at the C-3 position has been reported (Scheme 2) (Tanachatchairatana et al, 2008).…”

Section: Cinnamic Ester Derivativesmentioning

confidence: 99%

Cinnamic Derivatives in Tuberculosis

De¹,

Veau²,

Bedos‐Belval³

et al. 2012

Understanding Tuberculosis - New Approaches to Fighting Against Drug Resistance

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“…These compounds can be obtained from plants which are an important natural source of novel leads in the field of anti-tuberculosis therapeutics (Cantrell et al 2001, Copp and Pearce 2007, Gutierrez-Lugo and Bewley 2008.…”

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confidence: 99%

Natural Compounds from Mexican Medicinal Plants as Potential Drug Leads for Anti-Tuberculosis Drugs

Gómez-Cansino

Guzmán-Gutiérrez

Campos-Lara

et al. 2017

An. Acad. Bras. Ciênc.

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In Mexican Traditional Medicine 187 plant species are used in the treatment of respiratory conditions that may be associated with tuberculosis. In this contribution, we review the ethnobotany, chemistry and pharmacology of 63 species whose extracts have been assayed for antimycobacterial activity in vitro. Among these, the most potent is Aristolochia brevipes (MIC= 12.5 µg/mL), followed by Aristolochia taliscana, Citrus sinensis, Chrysactinia mexicana, Persea americana, and Olea europaea (MIC<64 µg/ mL). Other potent extracts (inhibition > 95%, 50 µg/mL) include: Amphipterygium adstringens, Larrea divaricata, and Phoradendron robinsoni. Several active compounds have been identified, the most potent are: Licarin A (isolated from A. taliscana), and 9-amino-9-methoxy-3,4-dihydro-2H-benzo[h]-chromen-2-one (transformation product of 9-methoxytariacuripyrone isolated from Aristolochia brevipes), both with MIC= 3.125 µg/mL, that is 8-fold less potent than the reference drug Rifampicin (MIC= 0.5 µg/mL). Any of the compounds or extracts here reviewed has been studied in clinical trials or with animal models; however, these should be accomplished since several are active against strains resistant to common drugs.

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Natural Product Growth Inhibitors of Mycobacterium tuberculosis

Abstract: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Cited by 48 publications

References 1 publication

Antimycobacterial evaluation and preliminary phytochemical investigation of selected medicinal plants traditionally used in Mozambique

Antimycobacterial evaluation and preliminary phytochemical investigation of selected medicinal plants traditionally used in Mozambique

Cinnamic Derivatives in Tuberculosis

Natural Compounds from Mexican Medicinal Plants as Potential Drug Leads for Anti-Tuberculosis Drugs

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