Natural‐Product Diversity of the New Caledonian Marine Ecosystem Compared to Other Ecosystems: A Pharmacologically Oriented View

Laurent, Dominique; Pietra, Francesco

doi:10.1002/cbdv.200490048

Cited by 21 publications

(18 citation statements)

References 277 publications

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“…This occurred to us in a preliminary presentation of arsenicin A at a meeting. [15] It was only the present comparative study of 4 and 7, providing firm ground for the unusual nature of the fragmentations that allowed us to point firmly to structure 4 for arsenicin A. To our great pleasure, a nice agreement was observed between experimental and theoretically calculated IR spectra-along the methodology de- …”

Section: Resultsmentioning

confidence: 56%

On the First Polyarsenic Organic Compound from Nature: Arsenicin A from the New Caledonian Marine Sponge Echinochalina bargibanti

Mancini

Guella

Frostin

et al. 2006

Chemistry A European J

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Reported here is the first polyarsenic compound ever found in nature. Denominated arsenicin A, it was isolated along a bioassay-guided fractionation of the organic extract of the poecilosclerid sponge Echinochalina bargibanti collected from the north-eastern coast of New Caledonia. In defining an adamantine-type polyarsenic structure for this compound, deceptively simple NMR spectra were complemented by extensive mass spectral analysis. However, it was only the synthesis of a model compound that provided the basis to discriminate structure 4 from other spectrally compatible structures for arsenicin A; to this end, a comparative ab initio simulation of IR spectra for the natural and the synthetic compounds was decisive. Arsenicin A is endowed with potent bactericidal and fungicidal activities on human pathogenic strains. All this may revive pharmacological interest in arsenic compounds while prompting us to rethink the arsenic cycle in nature.

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Section: Resultsmentioning

confidence: 56%

On the First Polyarsenic Organic Compound from Nature: Arsenicin A from the New Caledonian Marine Sponge Echinochalina bargibanti

Mancini

Guella

Frostin

et al. 2006

Chemistry A European J

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“…In this study, we aimed to explore the bio and chemodiversity of microalgae present in lagoons of New Caledonia, a well-known hotspot of biodiversity [37,38]. Specific environmental conditions (i.e., high UV radiation owing to the leaner ozone layer and high metal concentration of natural origin or caused by mining activity) made these lagoons a source of original microalgae strains with unusual phenotypes, and promising molecules.…”

Section: Introductionmentioning

confidence: 99%

Impact of Light Intensity on Antioxidant Activity of Tropical Microalgae

Coulombier¹,

Nicolau

Déan

et al. 2020

Marine Drugs

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Twelve microalgae species isolated in tropical lagoons of New Caledonia were screened as a new source of antioxidants. Microalgae were cultivated at two light intensities to investigate their influence on antioxidant capacity. To assess antioxidant property of microalgae extracts, four assays with different modes of action were used: 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-éthylbenzothiazoline-6-sulphonique) (ABTS), oxygen radical absorbance capacity (ORAC), and thiobabituric acid reactive substances (TBARS). This screening was coupled to pigment analysis to link antioxidant activity and carotenoid content. The results showed that none of the microalgae studied can scavenge DPPH and ABTS radicals, but Chaetoceros sp., Nephroselmis sp., and Nitzschia A sp. have the capacity to scavenge peroxyl radical (ORAC) and Tetraselmis sp., Nitzschia A sp., and Nephroselmis sp. can inhibit lipid peroxidation (TBARS). Carotenoid composition is typical of the studied microalgae and highlight the siphonaxanthin, detected in Nephroselmis sp., as a pigment of interest. It was found that xanthophylls were the major contributors to the peroxyl radical scavenging capacity measured with ORAC assay, but there was no link between carotenoids and inhibition of lipid peroxidation measured with TBARS assay. In addition, the results showed that light intensity has a strong influence on antioxidant capacity of microalgae: Overall, antioxidant activities measured with ORAC assay are better in high light intensity whereas antioxidant activities measured with TBARS assay are better in low light intensity. It suggests that different antioxidant compounds production is related to light intensity.

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“…Secosteroids and secosterols of marine invertebrate origin, specifically sponges, are well known and have been the subject of a number of studies [33], [34], [35], [36], [37]. These secosteroids, specifically 5,6-secosteroids, can theoretically result from the oxidation of cholesterol, but although the C5–C6 double bond in cholesterol can be easily oxidised, the secosterols observed here are not easily formed.…”

Section: Resultsmentioning

confidence: 86%

Evidence for Prehistoric Origins of Egyptian Mummification in Late Neolithic Burials

et al. 2014

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Traditional theories on ancient Egyptian mummification postulate that in the prehistoric period (i.e. the Neolithic and Chalcolithic periods, 5th and 4th millennia B.C.) bodies were naturally desiccated through the action of the hot, dry desert sand. Although molding of the body with resin-impregnated linen is believed to be an early Pharaonic forerunner to more complex processes, scientific evidence for the early use of resins in artificial mummification has until now been limited to isolated occurrences during the late Old Kingdom (c. 2200 B.C.), their use becoming more apparent during the Middle Kingdom (c. 2000-1600 BC). We examined linen wrappings from bodies in securely provenanced tombs (pit graves) in the earliest recorded ancient Egyptian cemeteries at Mostagedda in the Badari region (Upper Egypt). Our investigations of these prehistoric funerary wrappings using a combination of gas chromatography-mass spectrometry (GC-MS) and thermal desorption/pyrolysis (TD/Py)-GC-MS have identified a pine resin, an aromatic plant extract, a plant gum/sugar, a natural petroleum source, and a plant oil/animal fat in directly AMS-dated funerary wrappings. Predating the earliest scientific evidence by more than a millennium, these embalming agents constitute complex, processed recipes of the same natural products, in similar proportions, as those utilized at the zenith of Pharaonic mummification some 3,000 years later. The antibacterial properties of some of these ingredients and the localized soft-tissue preservation that they would have afforded lead us to conclude that these represent the very beginnings of experimentation that would evolve into the famous mummification practice of the Pharaonic period.

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Natural‐Product Diversity of the New Caledonian Marine Ecosystem Compared to Other Ecosystems: A Pharmacologically Oriented View

Cited by 21 publications

References 277 publications

On the First Polyarsenic Organic Compound from Nature: Arsenicin A from the New Caledonian Marine Sponge Echinochalina bargibanti

On the First Polyarsenic Organic Compound from Nature: Arsenicin A from the New Caledonian Marine Sponge Echinochalina bargibanti

Impact of Light Intensity on Antioxidant Activity of Tropical Microalgae

Evidence for Prehistoric Origins of Egyptian Mummification in Late Neolithic Burials

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