Natural Product as Avermectins and Milbemycins for Agriculture Perspectives

Bhardwaj, Kanchan; Abraham, Jayanthi; Kaur, Simran

doi:10.1007/978-981-15-3024-1_12

Cited by 2 publications

(3 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to the enzymes involved in pesticide resistance, the effects of chemical pesticides on pest biological development and fecundity may partially explain the rapid development of pesticide resistance; this topic has become an important research focus area (Bhardwaj et al, 2020;Kwon et al, 2010;Gao et al, 2010;He and Wang, 2015). Abamectin significantly impacts life history parameters including the duration of different developmental periods and the fecundity of the pest.…”

Section: Discussionmentioning

confidence: 99%

“…Abamectin is a 16-membered macrolide ring produced during the fermentation of Streptomyces avermitilis (Lasota & Dybas, 1991). It is the only highly effective and broad-spectrum bio-pesticide used in crop protection and medicine and is consequently widely used to control a variety of pest insects of crops, pest mites, and zoonotic parasites (Bhardwaj et al, 2020;Cui et al, 2018;Lloberas et al, 2013;VerduÂ et al, 2015). China is the primary abamectin manufacturer globally, and abamectin is also among the most commonly used bio-pesticides in China.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Detoxification enzyme activity, reproductive and developmental fitness of abamectin-resistant Bryobia praetiosa (Acari:Tetranychidae)

et al. 2022

View full text Add to dashboard Cite

Abamectin is an important and environmentally friendly antibiotic pesticide, and its resistance has become an area of intense research. In this study, we employed laboratory bioassays, biochemical analyses, and life history analyses to systematically evaluate abamectin resistance, the underlying biochemical mechanisms of resistance, and the reproductive and developmental characteristics of the arthropod pest Bryobia praetiosa. An abamectin-resistant B. praetiosa strain (RR) was obtained by intensive selection of an abamectin-susceptible strain (SS) using abamectin exposure in the laboratory for 24 generations, yielding a resistance index (RI) of 30.11. Comparison of detoxification enzymes suggested that the specific activities of carboxylesterases (CarEs), glutathione S-transferases (GSTs), and mixed-function oxidases (MFOs) in the RR strain were higher than those of the SS strain by 1.13-, 1.75-, and 4.02-fold, respectively. GST and MFOS protein concentrations were also significantly different between RR and SS strains. Further analysis of life history parameters demonstrated that the developmental duration and lifespan of RR strain in addition to egg numbers were markedly decreased relative to SS strain. The net reproductive rate (R0), finite rate of increase (λ), and population doubling time (Dt) of RR strain were significantly lower than those of SS strain. The results indicated that the RR strain was more disadvantageous in developmental and reproductive characteristics than the SS strain. In addition, the relative fitness value of the resistant strain is about half (Rf = 0.49) that of the susceptible strain. In conclusion, increased abamectin resistance in B. praetiosa was associated with a rapid increase in MFOs activity, while GSTs also played a role in abamectin resistance development and RR strain exhibited reproductive disadvantages.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detoxification enzyme activity, reproductive and developmental fitness of abamectin-resistant Bryobia praetiosa (Acari:Tetranychidae)

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Nicotinic signs of levamisole poisoning are represented by increased defecation and urination, anxiety, hyperesthesia, muscle tremor, and convulsions (Sharma et al, 2020).Ivermectin is a macrocyclic lactone isolated from the bacterium Streptomyces Avermitilis and it is commonly used against parasitic diseases in domestic and wild animals caused by roundworms, nematodes, and arthropods ( Campbell, 2012). It has also been used against internal and external worms that affect cattle and birds (Bhardwaj et al, 2020;Khalaf, 2022). This drug can kill roundworms, intestinal worms, and lungworms but does not affect flatworms or tapeworms (Pooda et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Acute Toxic Effects of levamisole and Ivermectin in Mice

Almawla,

Al-baggou

2023

Journal of Applied Veterinary Sciences

View full text Add to dashboard Cite

The study's objectives were to investigate the acute toxicity and related biochemical effects of levamisole and ivermectin in mice. The 24 h oral median lethal dose (LD50) of levamisole was determined by the up-and-down method and was 155.5 mg/ kg of body weight. The treated mice showed signs of acute poisoning represented by excessive grooming, lacrimation, piloerection, straub tail, tachycardia, bulged eyes, tremor, convulsion and finally death within 24 h of treatment. The approximate lethal dose (ALD) of levamisole was 368 mg/kg, and the mice showed signs of poisoning similar to the previous signs of poisoning within 24 h of treatment. The 24 h oral LD50 of ivermectin was 115.2 mg/kg and the mice showed acute signs of poisoning, represented by excessive grooming, lacrimation, closed eyelids, piloerection, tachycardia, rapid respiration, depression, flat body appearance, paralysis and finally death within 24 h of treatment, while the approximate lethal dose of ivermectin was 121 mg/kg and also with the presence of severe poisoning signs as mentioned before. Non-lethal toxic doses of levamisole at 100 and 150 mg/kg and ivermectin at 75 and 100 mg/kg led to significant blood biochemical changes after 24 h of treatment, represented by a significant increase in the activity of the enzymes alkaline phosphatase (ALP), lactate dehydrogenase (LDH), glutamate dehydrogenase (GDH), and a significantly increased total bilirubin concentration in the blood plasma of mice. These results proved the presence of acute toxicity and biochemical effects of both anthelmintics levamisole and ivermectin even though they have wide safety margins.

show abstract

Natural Product as Avermectins and Milbemycins for Agriculture Perspectives

Cited by 2 publications

References 57 publications

Detoxification enzyme activity, reproductive and developmental fitness of abamectin-resistant Bryobia praetiosa (Acari:Tetranychidae)

Detoxification enzyme activity, reproductive and developmental fitness of abamectin-resistant Bryobia praetiosa (Acari:Tetranychidae)

Acute Toxic Effects of levamisole and Ivermectin in Mice

Contact Info

Product

Resources

About