Natural polysaccharides platforms for oral controlled release of ketoprofen lysine salt

Abstract

The platform may be proposed as potentially useful in the oral administration of NSAIDs in chronic inflammatory diseases affected by circadian rhythm.

Zinc and Calcium Cations Combination in the Production of Floating Alginate Beads as Prednisolone Delivery Systems

“…About one-hundred-bead micrographs were analysed for each preparation and for at least three different prilling processes. Inner structure images were obtained by cryofracture of dried beads and further analysis by SEM, as previously reported [13]. In brief, freeze-fracture of the beads was performed by plunging the particles into liquid nitrogen for 1 min, and then fracturing the frozen beads by means of two needles.…”

“…Prilling is a mild and scalable microencapsulation technique working essentially through two steps: the breaking apart of a laminar jet of alginate solution into a row of mono-sized drops through a vibrating nozzle and the successive drops' ionotropic gelling in a solution of cations acting as crosslinkers. In the last few years, a large variety of gel-beads has been produced, varying the types of polysaccharides (mainly alginate, pectin, chitosan, and so on) used alone or in combination [10,11]; the configuration of the prilling apparatus to obtain 'only core' or core-shell beads [12]; and the gelling conditions in terms of cross-linker, pH of the reticulation solution, and gelling time [13,14]. Moreover, calcium alginate has often been used in combination with different gas-generating agents such as sodium bicarbonate, calcium carbonate, and citric acid or tartaric acid to obtain low-density floating formulations [15][16][17].…”

“…Systems floating in gastric medium can remain in the stomach for a prolonged period after oral administration; release the drug slowly [18][19][20]; and extend its in vivo effect, increasing both its therapeutic efficacy and safety with substantial benefits and a better patient compliance [21]. In particular, this approach can be interesting for API (active pharmaceutical ingredient) with a short half-life such as prednisolone (SAID, steroidal anti-inflammatory drug), useful to treat some chronic inflammatory diseases, which gain benefits from the reduction of the daily dose administered and correlated reduction of the side effects [13].…”

Core/shell cellulose‐based microspheres for oral administration of Ketoprofen Lysinate

“…In this context, the addition of ionic polymer layers able to be selectively dissolved under different environmental stimuli-such as CS-may be suitable to improve polar interactions among drug molecules in the diffusing media, thus influencing carrier properties (i.e., hydrophilicity, crystallinity) for a more accurate control drug encapsulation, and prolonged molecular release. [19][20][21] In this work, new cellulose based carriers have been engineered via electrofluidodynamics (EFDTs) to achieve a sustained release of KL for several hours after the in vitro administration. EFDTs include a set of innovative top down technologies based on simple fabrication processes able to design innovative devices with restrained manufacturing costs but high functional complexity, with great benefits in terms of pharmaceutical applications.…”

Nonsteroidal Anti-Inflammatory Drugs: A Difficult Choice of Anesthesia During Joint Surgery

“…Его центральное действие определяется изменением конфигурации G-белка, расположенного на постсинаптической мембране нейронов, что ведет к сни-жению афферентного сигнала боли. Микрогранулы за-медленного высвобождения обеспечивают равномерное распределение препарата в желудке и минимальный кон-такт со слизистой оболочкой [24].…”