Natural polysaccharides and proteins applied to the development of gastroresistant multiparticulate systems for anti-inflammatory drug delivery – A systematic review

Vieira, Wedja Timóteo; Nicollini, Maria Vitória Silva; Silva, Meuris Gurgel Carlos da; Vieira, Melissa Gurgel Adeodato

doi:10.1016/j.eurpolymj.2022.111205

Cited by 14 publications

(8 citation statements)

References 146 publications

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“…Both nanoencapsulated systems show a significantly lower release ( p < 0.05) than free maqui extract, 60% for CH-ME and 39% for CTPP-ME 3%, compared to 97% for ME at 240 min. The in vitro dissolution data of multi-particulate, anti-inflammatory drug delivery systems based on polysaccharides and proteins are fitted mainly to the Korsmeyer–Peppas model because this describes drug release from a polymeric system considering non-Fickian mechanisms [ 42 ]. In this study, the dissolution data for CH-ME (K = 0.0215; n = 0.5954 R 2 = 0.997) and CTPP-ME 3% (K = 0.003; n = 0.8833 R 2 = 0.9987) fitted well to the Korsmeyer–Peppas model.…”

Section: Resultsmentioning

confidence: 99%

Nanoencapsulation of Maqui (Aristotelia chilensis) Extract in Chitosan–Tripolyphosphate and Chenopodin-Based Systems

Andrade,

Maldonado-Bravo,

Alburquerque

et al. 2024

Antioxidants

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Maqui berries contain a high percentage of anthocyanins with high antioxidant and anti-inflammatory capacity but that are unstable in the colonic site. Nanocarriers based on polysaccharides and/or proteins can protect against the degradation of anthocyanins. The aim of this study was the nanoencapsulation of maqui extract (ME) in chitosan–tripolyphosphate (CTPP-ME), chenopodin (CH-ME), and chenopodin–alginate (CHA-ME). A standardised ME was prepared and then encapsulated in the nanosystems. The physicochemical properties, encapsulation parameters, and the interactions of ME with the nanovehicles were characterised. The cyanidin-3-glucoside released and ORAC activity in phosphate buffer at pH 7.4 were evaluated. The content of ME was 8–9 mg of cyanidin-3-glucoside/g of extract. CTPP with ME at 3% obtained the highest encapsulation efficiency (EE = 91%), and no significant differences were observed in size (274–362 nm), PDI (0.5–0.7), and zeta potential (+34–+41 mV) when the concentration of ME changed from 1% to 5%. CH-ME was shown to be smaller (152 nm) than CTPP-ME, and CH-ME and CHA-ME showed lower EE (79% and 54%, respectively) than CTPP-ME. FT-IR revealed a stronger interaction of ME with CTPP-ME than with CH-ME. Both systems showed a significantly lower release than free ME, and the T50 value of CTPP-ME 3% (328 min) was higher than CH-ME (197 min). Both protected the ORAC activity of ME.

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Section: Resultsmentioning

confidence: 99%

Nanoencapsulation of Maqui (Aristotelia chilensis) Extract in Chitosan–Tripolyphosphate and Chenopodin-Based Systems

Andrade,

Maldonado-Bravo,

Alburquerque

et al. 2024

Antioxidants

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“…The in vitro Qt dissolution of F4Qt, F5Qt, P4Qt, and P5Qt in PBS1X and Krebs buffer fits the Korsmeyer–Peppas model, capable of describing the release of drugs from polymers such as the QPA complex and QP, considering non-Fickian mechanisms [ 69 , 70 ]. See Table S3 .…”

Section: Resultsmentioning

confidence: 99%

Nanoemulsions Based on Soluble Chenopodin/Alginate Complex for Colonic Delivery of Quercetin

Intiquilla,

Arazo,

Gamboa

et al. 2024

Antioxidants

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Inflammatory bowel disease (IBD) is an autoimmune disorder caused by uncontrolled immune activation and the subsequent destruction of the colon tissue. Quercetin (Qt) is a natural antioxidant and anti-inflammatory agent proposed as an alternative to mitigate IBD. However, its use is limited by its low oral bioavailability. This study aimed to develop nanoemulsions (NEs) based on a soluble chenopodin/alginate (QPA) complex and Tween 80 (T80), intended for the colonic release of Qt, activated by the pH (5.4) and bacteria present in the human colonic microbiota. NEs with different ratios of QPA/Tw80 (F1-F6) were prepared, where F4Qt (60/40) and F5Qt (70/30) showed sizes smaller than 260 nm, PDI < 0.27, and high encapsulation efficiency (>85%). The stability was evaluated under different conditions (time, temperature, pH, and NaCl). The DSC and FTIR analyses indicated hydrophobic and hydrogen bonding interactions between QPA and Qt. F4Qt and F5Qt showed the greater release of Qt in PBS1X and Krebs buffer at pH 5.4 (diseased condition), compared to the release at pH 7.4 (healthy condition) at 8 h of study. In the presence of E. coli and B. thetaiotaomicron, they triggered the more significant release of Qt (ƒ2 < 50) compared to the control (without bacteria). The NEs (without Qt) did not show cytotoxicity in HT-29 cells (cell viability > 80%) and increased the antioxidant capacity of encapsulated Qt. Therefore, these NEs are promising nanocarriers for the delivery of flavonoids to the colon to treat IBD.

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“…MDDS comprises numerous independent units serving as drug carriers, collectively forming the complete dose. Typically, these multiple units have diameters ranging from micrometers (1–1000 μm) to millimeters (0.05–2.00 mm) and can take the form of granules, micro-particles (microspheres or micro-capsules), tablets (with a diameter of less than 3 mm), and pellets [ 119 ]⁠.…”

Section: Drugs and Bioactive Compounds In Vitro Release Studies Using...mentioning

confidence: 99%

Arabinoxylans matrixes as a potential material for drug delivery systems development - A bibliometric analysis and literature review

Pérez-Flores,

García-Curiel,

Pérez-Escalante

et al. 2024

Heliyon

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Natural polysaccharides and proteins applied to the development of gastroresistant multiparticulate systems for anti-inflammatory drug delivery – A systematic review

Cited by 14 publications

References 146 publications

Nanoencapsulation of Maqui (Aristotelia chilensis) Extract in Chitosan–Tripolyphosphate and Chenopodin-Based Systems

Nanoencapsulation of Maqui (Aristotelia chilensis) Extract in Chitosan–Tripolyphosphate and Chenopodin-Based Systems

Nanoemulsions Based on Soluble Chenopodin/Alginate Complex for Colonic Delivery of Quercetin

Arabinoxylans matrixes as a potential material for drug delivery systems development - A bibliometric analysis and literature review

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