Natural polysaccharide pullulan as anti-cancer drug carriers for hepatic targeting

Fan, Yujiang; Li, Huanan; Sun, Yong; Liang, Jie

doi:10.3389/conf.fbioe.2016.01.00349

Cited by 1 publication

(1 citation statement)

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“…Pullulan treatment upregulates the costimulatory molecular expression and enhances the pro-inflammatory cytokine production in bone marrow-derived dendritic cells (BMDCs) in vitro and in spleen DCs in vivo [ 167 , 168 ]. Pullulan induced the maturation of DCs in spleen- and tumour-draining lymph nodes (drLN) and in tumour-bearing mice and promoted the OVA-specific T cell activation and migration of the T cells into the tumour [ 169 , 170 ]. The combination of OVA and pullulan inhibited tumour growth and liver metastasis [ 171 , 172 ].…”

Section: Halophiles and Other Poly Extremophilesmentioning

confidence: 99%

The Cytotoxic Properties of Extreme Fungi’s Bioactive Components—An Updated Metabolic and Omics Overview

Kiss

Akbari

Marchev

et al. 2023

Life

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Fungi are the most diverse living organisms on planet Earth, where their ubiquitous presence in various ecosystems offers vast potential for the research and discovery of new, naturally occurring medicinal products. Concerning human health, cancer remains one of the leading causes of mortality. While extensive research is being conducted on treatments and their efficacy in various stages of cancer, finding cytotoxic drugs that target tumor cells with no/less toxicity toward normal tissue is a significant challenge. In addition, traditional cancer treatments continue to suffer from chemical resistance. Fortunately, the cytotoxic properties of several natural products derived from various microorganisms, including fungi, are now well-established. The current review aims to extract and consolidate the findings of various scientific studies that identified fungi-derived bioactive metabolites with antitumor (anticancer) properties. The antitumor secondary metabolites identified from extremophilic and extremotolerant fungi are grouped according to their biological activity and type. It became evident that the significance of these compounds, with their medicinal properties and their potential application in cancer treatment, is tremendous. Furthermore, the utilization of omics tools, analysis, and genome mining technology to identify the novel metabolites for targeted treatments is discussed. Through this review, we tried to accentuate the invaluable importance of fungi grown in extreme environments and the necessity of innovative research in discovering naturally occurring bioactive compounds for the development of novel cancer treatments.

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