Natural Polysaccharide-Based Hydrogels and Nanomaterials

Dave, Pragnesh N.; Gor, Ankur H.

doi:10.1016/b978-0-12-813351-4.00003-1

Cited by 69 publications

(30 citation statements)

References 252 publications

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“…Among the different types of materials to construct scaffolds for TE, hydrogels play a key role. These are three-dimensional cross-linked networks of polymers, proteins, and/or peptides [6] able to absorb and maintain large quantities of water inside without being dissolved thanks to their numerous hydrophilic groups, which allow extensive inner chemical and/or physical bonding. Hydrogel characteristics can be tuned by changes in the production manufacturing, composition, cross-linking degree, and microstructure, among others, to control the hydrogel mechanical and structural properties, water retention ability, and cytocompatibility, ultimately aiming to mimic those found in the extracellular matrix (ECM) of many human tissues.…”

Section: Introductionmentioning

confidence: 99%

Hybrid Methacrylated Gelatin and Hyaluronic Acid Hydrogel Scaffolds. Preparation and Systematic Characterization for Prospective Tissue Engineering Applications

Velasco

Diaz‐Vidal

Rosales-Rivera

et al. 2021

IJMS

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Hyaluronic acid (HA) and gelatin (Gel) are major components of the extracellular matrix of different tissues, and thus are largely appealing for the construction of hybrid hydrogels to combine the favorable characteristics of each biopolymer, such as the gel adhesiveness of Gel and the better mechanical strength of HA, respectively. However, despite previous studies conducted so far, the relationship between composition and scaffold structure and physico-chemical properties has not been completely and systematically established. In this work, pure and hybrid hydrogels of methacroyl-modified HA (HAMA) and Gel (GelMA) were prepared by UV photopolymerization and an extensive characterization was done to elucidate such correlations. Methacrylation degrees of ca. 40% and 11% for GelMA and HAMA, respectively, were obtained, which allows to improve the hydrogels’ mechanical properties. Hybrid GelMA/HAMA hydrogels were stiffer, with elastic modulus up to ca. 30 kPa, and porous (up to 91%) compared with pure GelMA ones at similar GelMA concentrations thanks to the interaction between HAMA and GelMA chains in the polymeric matrix. The progressive presence of HAMA gave rise to scaffolds with more disorganized, stiffer, and less porous structures owing to the net increase of mass in the hydrogel compositions. HAMA also made hybrid hydrogels more swellable and resistant to collagenase biodegradation. Hence, the suitable choice of polymeric composition allows to regulate the hydrogels´ physical properties to look for the most optimal characteristics required for the intended tissue engineering application.

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Section: Introductionmentioning

confidence: 99%

Hybrid Methacrylated Gelatin and Hyaluronic Acid Hydrogel Scaffolds. Preparation and Systematic Characterization for Prospective Tissue Engineering Applications

Velasco

Diaz‐Vidal

Rosales-Rivera

et al. 2021

IJMS

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“…It is possible that the presence of PS increases the solubility parameter of DPNR, which leads to power of solvent resistance [ 27 ]. Moreover, during grafting process, the presence of TEPA/TBHPO as initiator and cross-linker generated active sites on DPNR chain and then to form a physical crosslinked network which restrict the diffusion of solvent that resulted in lower swelling ratio and higher gel content [ 45 ]. However, the addition of St monomer above 15 phr caused an increase in the swelling ratio of DPNR-g-PS and a decrease in the gel fraction due to lower grafting efficiency, which led to reduced solvent resistance.…”

Section: Resultsmentioning

confidence: 99%

Radiation Graft-Copolymerization of Ultrafine Fully Vulcanized Powdered Natural Rubber: Effects of Styrene and Acrylonitrile Contents on Thermal Stability

et al. 2021

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Graft copolymers, deproteinized natural rubber-graft-polystyrene (DPNR-g-PS) and deproteinized natural rubber-graft-polyacrylonitrile (DPNR-g-PAN), were prepared by the grafting of styrene (St) or acrylonitrile (AN) monomers onto DPNR latex via emulsion copolymerization. Then, ultrafine fully vulcanized powdered natural rubbers (UFPNRs) were produced by electron beam irradiation of the graft copolymers in the presence of di-trimethylolpropane tetra-acrylate (DTMPTA) as a crosslinking agent and, subsequently, a fast spray drying process. The effects of St or AN monomer contents and the radiation doses on the chemical structure, thermal stability, and physical properties of the graft copolymers and UFPNRs were investigated. The results showed that solvent resistance and grafting efficiency of DPNR-g-PS and DPNR-g-PAN were enhanced with increasing monomer content. SEM morphology of the UFPNRs showed separated and much less agglomerated particles with an average size about 6 μm. Therefore, it is possible that the developed UFPNRs grafted copolymers with good solvent resistance and rather high thermal stability can be used easily as toughening modifiers for polymers and their composites.

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“…Injectable delivery vehicle of therapeutic drugs or cells for tissue regenerative medicine [91] The use of synthetic polymer polysaccharides, such as chitosan, cellulose, alginic acid, hyaluronic acid, and their derivatives, has been the study of increased research in tissue engineering applications. Polysaccharide is an attractive material due to its biodegradability, polyfunctionality, and biocompatibility with living tissue according to the desired application [92]. For instance, a self-healing hydrogel was manufactured using chitosan and PEG derivatives based on imine bonds due to its highly biocompatible nature.…”

Section: Self-healing Polymeric Materials and Their Efficiency As Healing Agents In Medical Fieldsmentioning

confidence: 99%

The Versatility of Polymeric Materials as Self-Healing Agents for Various Types of Applications: A Review

et al. 2021

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The versatility of polymeric materials as healing agents to prevent any structure failure and their ability to restore their initial mechanical properties has attracted interest from many researchers. Various applications of the self-healing polymeric materials are explored in this paper. The mechanism of self-healing, which includes the extrinsic and intrinsic approaches for each of the applications, is examined. The extrinsic mechanism involves the introduction of external healing agents such as microcapsules and vascular networks into the system. Meanwhile, the intrinsic mechanism refers to the inherent reversibility of the molecular interaction of the polymer matrix, which is triggered by the external stimuli. Both self-healing mechanisms have shown a significant impact on the cracked properties of the damaged sites. This paper also presents the different types of self-healing polymeric materials applied in various applications, which include electronics, coating, aerospace, medicals, and construction fields. It is expected that this review gives a significantly broader idea of self-healing polymeric materials and their healing mechanisms in various types of applications.

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Natural Polysaccharide-Based Hydrogels and Nanomaterials

Cited by 69 publications

References 252 publications

Hybrid Methacrylated Gelatin and Hyaluronic Acid Hydrogel Scaffolds. Preparation and Systematic Characterization for Prospective Tissue Engineering Applications

Hybrid Methacrylated Gelatin and Hyaluronic Acid Hydrogel Scaffolds. Preparation and Systematic Characterization for Prospective Tissue Engineering Applications

Radiation Graft-Copolymerization of Ultrafine Fully Vulcanized Powdered Natural Rubber: Effects of Styrene and Acrylonitrile Contents on Thermal Stability

The Versatility of Polymeric Materials as Self-Healing Agents for Various Types of Applications: A Review

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