Natural polyphenols-gut microbiota interactions and effects on glycolipid metabolism via polyphenols-gut-brain axis: A state-of-the-art review

Xie, Fan; Yang, Wanling; Xing, Mingxia; Zhang, Hui; Ai, Lianzhong

doi:10.1016/j.tifs.2023.104171

Cited by 19 publications

(5 citation statements)

References 113 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies support the preventive role of polyphenols in the fight against diseases [127], free radicals, gut health [128], and cholesterol oxidation products [129], among others. Additionally, Xie et al state that the polyphenols-gut-brain axis may be a key way to regulate glycolipid metabolism [130]. Other authors also report that gut microbiota-polyphenols positively affect human physiological processes [130,131].…”

Section: Wellbeing and Prevention Through Nutritionmentioning

confidence: 99%

“…Additionally, Xie et al state that the polyphenols-gut-brain axis may be a key way to regulate glycolipid metabolism [130]. Other authors also report that gut microbiota-polyphenols positively affect human physiological processes [130,131]. Polyphenols not only stimulate the growth of amicable probiotic colonies but also lower the number of pathogenic bacteria [132].…”

Section: Wellbeing and Prevention Through Nutritionmentioning

confidence: 99%

See 1 more Smart Citation

Dietary Phenolic Compounds—Wellbeing and Perspective Applications

Mihaylova,

Dimitrova-Dimova,

Popova

2024

IJMS

View full text Add to dashboard Cite

Contemporary living is continuously leading to poor everyday choices resulting in the manifestation of various diseases. The benefits of plant-based nutrition are undeniable and research on the topic is rising. Modern man is now aware of the possibilities that plant nutrition can provide and is seeking ways to benefit from it. Dietary phenolic compounds are among the easily accessible beneficial substances that can exhibit antioxidant, anti-inflammatory, antitumor, antibacterial, antiviral, antifungal, antiparasitic, analgesic, anti-diabetic, anti-atherogenic, antiproliferative, as well as cardio-and neuroprotective activities. Several industries are exploring ways to incorporate biologically active substances in their produce. This review is concentrated on presenting current information about the dietary phenolic compounds and their contribution to maintaining good health. Additionally, this content will demonstrate the importance and prosperity of natural compounds for various fields, i.e., food industry, cosmetology, and biotechnology, among others.

show abstract

Section: Wellbeing and Prevention Through Nutritionmentioning

confidence: 99%

Section: Wellbeing and Prevention Through Nutritionmentioning

confidence: 99%

Dietary Phenolic Compounds—Wellbeing and Perspective Applications

Mihaylova,

Dimitrova-Dimova,

Popova

2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Many studies have reported that polyphenols can suppress the pathogens induced by an HFD, such as Clostridium difficile , Clostridium perfrigens , and Bacteroides spp., and stimulate the probiotics, including Lactobacillus , Faecalibacterium prasnutzii , and Bifidobacterium . 1,3,9 Consequently, modulated gut microbiota contribute to the host's anti-obesity-related health benefits.…”

Section: Introductionmentioning

confidence: 99%

Benefits of Monascus anka solid-state fermentation for quinoa polyphenol bioaccessibility and the anti-obesity effect linked with gut microbiota

Huang,

Chu,

Yang

et al. 2024

Food Funct.

View full text Add to dashboard Cite

show abstract

“…Therefore, modulating gut microbiota or their metabolites (SCFAs and BAs) may represent a potential strategy for improving intestinal oxidative stress. Recent findings have suggested that polyphenolic compounds positively affect the stability of gut microbiota and their metabolic products [ 12 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Hydroxytyrosol Alleviates Intestinal Oxidative Stress by Regulating Bile Acid Metabolism in a Piglet Model

Wen,

Wan,

Zhong

et al. 2024

IJMS

View full text Add to dashboard Cite

Infants and young animals often suffer from intestinal damage caused by oxidative stress, which may adversely affect their overall health. Hydroxytyrosol, a plant polyphenol, has shown potential in decreasing intestinal oxidative stress, but its application and mechanism of action in infants and young animals are still inadequately documented. This study selected piglets as a model to investigate the alleviating effects of hydroxytyrosol on intestinal oxidative stress induced by diquat and its potential mechanism. Hydroxytyrosol improved intestinal morphology, characterized by higher villus height and villus height/crypt depth. Meanwhile, hydroxytyrosol led to higher expression of Occludin, MUC2, Nrf2, and its downstream genes, and lower expression of cytokines IL-1β, IL-6, and TNF-α. Both oxidative stress and hydroxytyrosol resulted in a higher abundance of Clostridium_sensu_stricto_1, and a lower abundance of Lactobacillus and Streptococcus, without a significant effect on short-chain fatty acids levels. Oxidative stress also led to disorders in bile acid (BA) metabolism, such as the lower levels of primary BAs, hyocholic acid, hyodeoxycholic acid, and tauroursodeoxycholic acid, which were partially restored by hydroxytyrosol. Correlation analysis revealed a positive correlation between these BA levels and the expression of Nrf2 and its downstream genes. Collectively, hydroxytyrosol may reduce oxidative stress-induced intestinal damage by regulating BA metabolism.

show abstract

Natural polyphenols-gut microbiota interactions and effects on glycolipid metabolism via polyphenols-gut-brain axis: A state-of-the-art review

Cited by 19 publications

References 113 publications

Dietary Phenolic Compounds—Wellbeing and Perspective Applications

Dietary Phenolic Compounds—Wellbeing and Perspective Applications

Benefits of Monascus anka solid-state fermentation for quinoa polyphenol bioaccessibility and the anti-obesity effect linked with gut microbiota

Hydroxytyrosol Alleviates Intestinal Oxidative Stress by Regulating Bile Acid Metabolism in a Piglet Model

Contact Info

Product

Resources

About