Natural Polyphenols: Biological Activity, Pharmacological Potential, Means of Metabolic Engineering (Review)

Теплова, В. В.; Исакова, Е. П.; Klein, O. I.; Dergachova, D.I.; Гесслер, Н. Н.; Deryabina, Yulia I.

doi:10.1134/s0003683818030146

Cited by 56 publications

(43 citation statements)

References 149 publications

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“…The natural world is a priceless source of valuable medical compounds and also in the fight against viral diseases there are several natural molecules which exhibit antiviral activity [105][106][107][108][109]. Coumarins, likewise other polyphenolic compounds, exert a remarkable antiviral activity [110,111]. The antiviral activity of coumarins explicates through different mechanisms which affect the life cycle of viruses and their biological activities could be changed depending upon the combination of various substituents and conjugates [104,112].…”

Section: Antiviral Activitymentioning

confidence: 99%

An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities

Annunziata

Pinna

Dallavalle

et al. 2020

IJMS

250

156

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Privileged structures have been widely used as an effective template for the research and discovery of high value chemicals. Coumarin is a simple scaffold widespread in Nature and it can be found in a considerable number of plants as well as in some fungi and bacteria. In the last years, these natural compounds have been gaining an increasing attention from the scientific community for their wide range of biological activities, mainly due to their ability to interact with diverse enzymes and receptors in living organisms. In addition, coumarin nucleus has proved to be easily synthetized and decorated, giving the possibility of designing new coumarin-based compounds and investigating their potential in the treatment of various diseases. The versatility of coumarin scaffold finds applications not only in medicinal chemistry but also in the agrochemical field as well as in the cosmetic and fragrances industry. This review is intended to be a critical overview on coumarins, comprehensive of natural sources, metabolites, biological evaluations and synthetic approaches.

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Section: Antiviral Activitymentioning

confidence: 99%

An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities

Annunziata

Pinna

Dallavalle

et al. 2020

IJMS

250

156

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“…OANCEA, PERJU and OLOSUTEAN been intensively studied because of their remarkable biological activities and uses. [1][2][3] Medicinal, aromatic and culinary herbs are rich sources of such compounds, but flowers of ornamental use may contain higher amounts of bioactive compounds, thus becoming potential sustainable sources of bioingredients.…”

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confidence: 99%

Influence of enzyme-aided extraction and ultrasonication on the phenolics content and antioxidant activity of Paeonia officinalis L. petals

2020

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Peony is a less utilized herbaceous plant of ornamental and medicinal relevance. The petals are rich in bioactive phenolics and hence, the development of efficient extraction is required for maximum recovery and bioactivity. In this study, the optimal conditions for the ultrasound-assisted extraction of peony phenolics were first investigated by comparing to conventional extraction and testing the data fit by mathematical models (linear, two factor interactions, quadratic) followed by investigation of cellulase pre-treatment combined with ultrasonication. High amounts of flavonoids, phenolics and tannins were extracted in 30 min under ultrasound conditions of 150 W, 40 kHz, 50 % amplitude, in 70 % ethanol with 50/1 solvent/solid ratio. A further cellulase pre-treatment at 40 °C for different incubation times combined with ultrasonication facilitated the extraction of anthocyanins (720.48 mg/100 g DW), phenolics (3985.50 mg/100 g DW), flavonoids (2369.28 mg/100 g DW) and tannins (8917.81 mg/100 g DW). Good antioxidant activities by FRAP (350.03 mg ascorbic acid/100 g DW) and DPPH (inhibition values >80 %) were registered showing great potential for developing high-value bioingredients. The FTIR analysis revealed the presence of characteristic functional groups. The hereby-combined extraction methods could be extended to other peony species.

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“…As an alternative to these conventional treatment agents, it is possible to use natural bioactive complexes extracted from plants, such as phenolic acids, flavonoids, tannins or lignans. In particular, polyphenols have been shown to feature a remarkable antimicrobial activity [7][8][9][10]. However, their applicability is limited by their low solubility and bioavailability [11], which may be improved through the formation of inclusion compounds with, for instance, terpene glycosides [12].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Antifungal Activity of Chitosan-Polyphenol Conjugates against Phytophthora cinnamomi

et al. 2020

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Phytophthora cinnamomi is responsible for radical rot in a wide range of hosts, resulting in large economic and ecological losses worldwide. In Spain, it is responsible for diseases such as the oak decline or the chestnut blight. In this study, different polyphenol-stevioside inclusion compounds dispersed in a hydroalcoholic solution of chitosan oligomers have been investigated, with a view to their application as natural bioactive complexes to replace conventional systemic fungicides against this fungus. The polyphenols tested in vitro were curcumin, ferulic acid, gallic acid and silymarin. Three concentrations (125, 250 and 500 µg·mL −1 ) were assayed, with and without silver nanoparticles (AgNPs), and notable differences were found in the inhibition of mycelium growth, with EC 50 and EC 90 values ranging from 171 to 373.6 µg·mL −1 , and from 446.2 to 963.7 µg·mL −1 , respectively. The results obtained showed that the addition of AgNPs, despite their antimicrobial activity, did not always lead to synergies. In the case of P. cinnamomi, an unexpected antagonistic behavior was found for two of the polyphenols (curcumin and silymarin), while an additive behavior for ferulic acid and a synergistic behavior for gallic acid were attained. In view of their inhibitory power, the preparations based on ferulic acid with AgNPs and on silymarin without AgNPs are proposed for applications in crop and forests protection against P. cinnamomi.

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Natural Polyphenols: Biological Activity, Pharmacological Potential, Means of Metabolic Engineering (Review)

Cited by 56 publications

References 149 publications

An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities

An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities

Influence of enzyme-aided extraction and ultrasonication on the phenolics content and antioxidant activity of Paeonia officinalis L. petals

In Vitro Antifungal Activity of Chitosan-Polyphenol Conjugates against Phytophthora cinnamomi

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