Natural Polyphenols and Spinal Cord Injury

Khalatbary, Ali Reza

doi:10.6091/ibj.1278.2014

Cited by 7 publications

(2 citation statements)

References 113 publications

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“…To reduce OS after SCI, many natural polyphenolic combinations have been used [ 52 ]. These compounds impede the restoration of molecules following free radical damage and control various dysregulated pathways/mediators, such as blocking production.…”

Section: Polyphenols In Spinal Cord Injurymentioning

confidence: 99%

Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision

Islam

Bepary

Nafady

et al. 2022

Oxidative Medicine and Cellular Longevity

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A spinal cord injury (SCI) occurs when the spinal cord is deteriorated or traumatized, leading to motor and sensory functions lost even totally or partially. An imbalance within the generation of reactive oxygen species and antioxidant defense levels results in oxidative stress (OS) and neuroinflammation. After SCI, OS and occurring pathways of inflammations are significant strenuous drivers of cross-linked dysregulated pathways. It emphasizes the significance of multitarget therapy in combating SCI consequences. Polyphenols, which are secondary metabolites originating from plants, have the promise to be used as alternative therapeutic agents to treat SCI. Secondary metabolites have activity on neuroinflammatory, neuronal OS, and extrinsic axonal dysregulated pathways during the early stages of SCI. Experimental and clinical investigations have noted the possible importance of phenolic compounds as important phytochemicals in moderating upstream dysregulated OS/inflammatory signaling mediators and axonal regeneration’s extrinsic pathways after the SCI probable significance of phenolic compounds as important phytochemicals in mediating upstream dysregulated OS/inflammatory signaling mediators. Furthermore, combining polyphenols could be a way to lessen the effects of SCI.

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Section: Polyphenols In Spinal Cord Injurymentioning

confidence: 99%

Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision

Islam

Bepary

Nafady

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…Nevertheless, oral luteolin supplementation in a quasi-experimental study was not superior to placebo at reducing symptoms of Gulf War Illness, a neuroinflammatory condition [ 336 ]. Oleuropein has demonstrated neuroprotective effects in animal models of cerebral ischemia, cerebral reperfusion injury, ageing, Alzheimer’s disease, Huntington’s disease, multiple sclerosis, Parkinson’s disease, peripheral neuropathy, spinal cord injury, and epilepsy [ 337 , 338 ]. With respect to Alzheimer’s disease, oleocanthal was shown to increase neuronal clearance of β-amyloid by increasing P-glycoprotein (P-gp) and LDL receptor-related protein-1 (LRP1) levels in mouse brains [ 339 ], while restoring the blood–brain barrier function and reducing neuroinflammation through inhibition of PYD domain-containing protein 3 (NLRP3) inflammasome and inducing autophagy through activation of the AMP-activated protein kinase/Unc-51-like autophagy activating kinase 1 (AMPK/ULK1) pathway [ 340 ].…”

Section: Resultsmentioning

confidence: 99%

Therapeutic Properties and Use of Extra Virgin Olive Oil in Clinical Nutrition: A Narrative Review and Literature Update

et al. 2022

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Extra virgin olive oil (EVOO) is a cornerstone of the Mediterranean diet (MedD). In this narrative review, we synthesize and illustrate the various characteristics and clinical applications of EVOO and its components—such as oleic acid, hydroxytyrosol, and oleuropein—in the field of clinical nutrition and dietetics. The evidence is split into diet therapy, oleic acid-based enteral nutrition formulations and oral supplementation formulations, oleic acid-based parenteral nutrition, and nutraceutical supplementation of minor components of EVOO. EVOO has diverse beneficial health properties, and current evidence supports the use of whole EVOO in diet therapy and the supplementation of its minor components to improve cardiovascular health, lipoprotein metabolism, and diabetes mellitus in clinical nutrition. Nevertheless, more intervention studies in humans are needed to chisel specific recommendations for its therapeutic use through different formulations in other specific diseases and clinical populations.

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Research Progress of Antioxidants in Oxidative Stress Therapy after Spinal Cord Injury

et al. 2023

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Natural Polyphenols and Spinal Cord Injury

Cited by 7 publications

References 113 publications

Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision

Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision

Therapeutic Properties and Use of Extra Virgin Olive Oil in Clinical Nutrition: A Narrative Review and Literature Update

Research Progress of Antioxidants in Oxidative Stress Therapy after Spinal Cord Injury

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