Natural polymers for vaginal mucoadhesive delivery of vinegar, using design of experiment methods

Parvinroo, Shirin; Eslami, Maede; Ebrahimi‐Najafabadi, Heshmatollah; Hesari, Zahra

doi:10.2298/vsp200804121p

Cited by 6 publications

(4 citation statements)

References 41 publications

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“…Therefore, mucoadhesion decreased from F 1 to F 6 (77.71-54.49 dynecm -2 ). F 7 and F 8 with highest polymer concentration (5%) showed higher mucoadhesion, noting that TG revealed higher adhesion in comparison with XG in equal polymer concentration as was observed previously in (Parvinroo, Eslami, Ebrahimi-Najafabadi, & Hesari, 2020) (Table 2).…”

Section: Mucoadhesive Propertiessupporting

confidence: 80%

Tragacanth and xanthan gum natural polymers for formulation of clotrimazole mucoadhesive gel

Hesari¹,

Emmamzadehhashemi²,

Aboutaleb³

2022

Acta Sci. Health Sci.

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Clotrimazole is an antifungal agent, widely used in vulvovaginal and oropharyngeal candidiasis. Currently available clotrimazole (especially vaginal) dosage forms, have some limitations, including: leakage, messiness and low residence time, which leads to poor patient compliance. Therefore, in this study, a clotrimazole mucoadhesive gel has been developed as a suitable strategy due to their high water content, increased local retention time, lubrication and patient compliance. Xanthan gum and tragacanth with different portions were utilized as natural mucoadhesive gel forming polymers. Gel formulations were subjected to physico-chemical evaluations including gel viscosity, FTIR spectroscopy, spreadability, scanning electron microscopy (SEM) images of hydrogel chains, and release kinetic. Results demonstrated that among 8 developed formulas, formulation F1 showed the appropriate properties including controlled drug release (63.13% in 6h) with higuchi release kinetic, higher mucoadhesion (77.71 dyne cm-1) and drug content (94.47%) and relatively low spreadability (3.5 cm) which is suitable for local drug delivery. FTIR spectroscopy revealed there is not incompatibility between clotrimazole and other excipients in formulations. Combination of natural polysaccharides can form a proper mucoadhesive gel matrix for delivery of synthetic or natural drugs.

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Section: Mucoadhesive Propertiessupporting

confidence: 80%

Tragacanth and xanthan gum natural polymers for formulation of clotrimazole mucoadhesive gel

Hesari¹,

Emmamzadehhashemi²,

Aboutaleb³

2022

Acta Sci. Health Sci.

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“…The mucus layer comprises enzymes, carbohydrates, lipids, nucleic acids, and salts that not only helps in providing defense against microbial infections but can also facilitate absorption of drug molecules in case they are delivered in adequate mucoadhesive formulations. Here, five formulations of ADP (AC1, AC2, ACX1, ACX2, and ACX3) were developed using different concentrations of the selected polymers, namely, Carbopol 934 and HPMC along with xanthan gum, which have already been reported to have mucoadhesive properties ( Bilensoy et al, 2006 ; Andrade et al, 2014 ; Parvinroo et al, 2022 ). The polymers in the mucoadhesive formulations initially swell and physically connect to the mucin on the tissue followed by the strong chemical interaction of the polymer and the mucus membrane ( Osmałek et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Development of mucoadhesive adapalene gel for biotherapeutic delivery to vaginal tissue

Afzaal

Shahiq-uz-Zaman²,

Saeed³

et al. 2022

Front. Pharmacol.

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Purpose: Alternate formulation strategies need to be devised for improving the absorption and bioavailability of drug molecules administered through the intravaginal route. Enhancing the coating of vaginal mucosa can aid the achievement of this goal. The aim of the current study is to develop a mucoadhesive formulation having adequate adhesiveness, spreading, and viscosity profiles that can ensure good tissue absorption of adapalene upon intravaginal application.Method: A combination of mucoadhesive agents has been employed, including Carbopol-934, HPMC K-15M, and xanthan gum, in varying ratios to formulate five different gels. Furthermore, a cost-effective UV-spectroscopic analytical method was developed to quantify the amount of adapalene in tested samples, both of in vitro and in vivo origin. The analytical method was validated for different parameters, including specificity, linearity, range, accuracy, precision, and ruggedness. The modified USP-II apparatus was used for dissolution studies, while in vivo pharmacokinetic validation was performed in a murine model.Result: Of all the tested formulations, on the basis of the rheo-mechanical attributes, ACX3 performed better than the rest, including the commercially available intravaginal reference product. ACX3 had an average adhesion time of 12 min and a spread diameter of 37 mm. It showed 35 mm as average distance travelled by the diluted sample for leakage assessment. The analytical method developed for the adapalene muco-adhesive gel was within the range for all the validation parameters. For further evaluating the performance of the formulation, dissolution studies were conducted in simulated vaginal conditions which showed 94.83% of drug release within 5 minutes, while on completion of 30 min, it was measured to be 92.90%. Moreover, approximately 67% of the administered drug was recovered after 5 min of administration as evaluated through tissue recovery procedures in mice.Conclusion: The study aided in development of a formulation which can enhance the muco-adhesion of the drug molecule, resulting in an improved pharmacokinetic profile. Moreover, it established an efficient assay method which can be employed for in vitro and in vivo quantification of adapalene in simulated and physiological fluids.

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“…This gel layer was air dried at 25 °C in a desiccator and dried gels were gold sputter coated before FESEM. Samples were observed using an accelerating voltage of 10 kV, a working distance of around 4.4 mm, and magnification between 1 and 50 KX [ 42 ].…”

Section: Methodsmentioning

confidence: 99%

Development and characterization of a topical gel, containing lavender (Lavandula angustifolia) oil loaded solid lipid nanoparticles

Fahimnia,

Nemattalab,

Hesari

2024

BMC Complement Med Ther

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Gels loaded with nanocarriers offer interesting ways to create novel therapeutic approaches by fusing the benefits of gel and nanotechnology. Clinical studies indicate that lavender oil (Lav-O) has a positive impact on accelerating wound healing properly based on its antimicrobial and anti-inflammatory effects. Initially Lav-O loaded Solid Lipid Nanoparticles (Lav-SLN) were prepared incorporating cholesterol and lecithin natural lipids and prepared SLNs were characterized. Next, a 3% SLN containing topical gel (Lav-SLN-G) was formulated using Carbopol 940. Both Lav-SLN and Lav-SLN-G were assessed in terms antibacterial effects against S. aureus. Lav-SLNs revealed a particle size of 19.24 nm, zeta potential of -21.6 mv and EE% of 75.46%. Formulated topical gel presented an acceptable pH and texture properties. Minimum Inhibitory/Bactericidal Concentration (MIC/MBC) against S. aureus for LAv-O, Lav-SLN and Lav-SLN-G were 0.12 and 0.24 mgml− 1, 0.05 and 0.19 mgml− 1 and 0.045, 0.09 mgml− 1, respectively. Therefore, SLN can be considered as an antimicrobial potentiating nano-carrier for delivery of Lav-O as an antimicrobial and anti-inflammatory agent in topical gel.

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Natural polymers for vaginal mucoadhesive delivery of vinegar, using design of experiment methods

Cited by 6 publications

References 41 publications

Tragacanth and xanthan gum natural polymers for formulation of clotrimazole mucoadhesive gel

Tragacanth and xanthan gum natural polymers for formulation of clotrimazole mucoadhesive gel

Development of mucoadhesive adapalene gel for biotherapeutic delivery to vaginal tissue

Development and characterization of a topical gel, containing lavender (Lavandula angustifolia) oil loaded solid lipid nanoparticles

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