Natural Polymer Chitosan as Super Disintegrant in Fast Orally Disintegrating Meloxicam Tablets: Formulation and Evaluation

Drakšienė, Gailutė; Venclovaite, Brigita; Pudžiuvelytė, Lauryna; Ivanauskas, Liudas; Marksa, Mindaugas; Bernatonienė, Jurga

doi:10.3390/pharmaceutics13060879

Cited by 4 publications

(1 citation statement)

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“…The fast disintegration of tablets comprising the conjugates can be attributed to the formation of voids which promote quick penetration of the dissolution medium into the tablets. This further leads to swelling and wicking action, creating hydrodynamic pressure inside the tablets and destroying the physical bonds between the particles [21]. The formulated FDTs were compared with the marketed formulation of Domperidone (MKTD).…”

Section: Kawakita Function Analysismentioning

confidence: 99%

Development and Evaluation of MCC-SiO2/CMC-SiO2 Conjugates as Tablet Super-Disintegrants

et al. 2022

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In the present study, microcrystallinecellulose–colloidal silicon dioxide (MCC-SiO2) and carboxymethylcellulose–colloidal silicon dioxide (CMC-SiO2) conjugates have been investigated as superdisintegrants in fast dissolving tablets (FDTs). MCC-SiO2 and CMC-SiO2 conjugates were prepared and micromeritic studies, FTIR, SEM and XRD methods were utilized for characterizing the powdered conjugates. The conjugates were used for the preparation of domperidone FDTs by direct compression and thewetting time, water absorption ratio, disintegration time and in vitro drug release were evaluated. Effective pore radius of MCC-SiO2 and CMC-SiO2 conjugates for 1:1, 1:2.5 and 1:5 was found to be 13.35 ± 0.31 µm, 15.66 ± 0.17 µm and 18.38 ± 0.44 µm, and 16.81 ± 0.24 µm, 20.12 ± 0.39 µm and 26.37 ± 0.24 µm, respectively, compared to 12.21 ± 0.23 µm for MCC and 13.65 ± 0.21 µm for CMC. The results of effective pore radius indicate the wicking capability as well as the disintegration potential of MCC-SiO2 and CMC-SiO2 conjugates over pure MCC and CMC. The results of wetting time, water absorption ratio and disintegration time for MCC-SiO2 conjugates were found to be in the range of 19 ± 1.21 to 30 ± 1.33 s, 42 ± 0.28 to 49 ± 0.47% and 15 ± 2 to 40 ± 1 s, and for CMC-SiO2 conjugates were found to be in the range of 21 ± 1.13 to 40 ± 1.17 s, 42 ± 0.94 to 49 ± 0.57% and 12 ± 2 to 20 ± 3 s, respectively. Conjugation of MCC and CMC with SiO2 led to the formation of a complex with remarkable tablet superdisintegrant potential that could be used in preparing fast disintegrating tablets.

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Section: Kawakita Function Analysismentioning

confidence: 99%