Natural Polymer-Cell Bioconstructs for Bone Tissue Engineering

Titorencu, Irina; Albu, Mădălina Georgiana; Nemecz, Miruna; Jinga, V.

doi:10.2174/1574888x10666151102105659

Cited by 32 publications

(14 citation statements)

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“…In this aspect, the major requirements for the scaffolds are biocompatibility, suitable pore size, volumetric porosity, permeability and compatible stiffness and strength to the bone that is being replaced. Although bio-ceramics [162][163][164] and polymers [165][166][167] are commonly used to make tissue scaffolds, their mechanical strengths are in most cases inadequate for critical length defects. Accordingly, porous biocompatible metallic structures with matched permeability, stiffness and strength are preferable [168].…”

Section: Discussionmentioning

confidence: 99%

Mechanical performance of highly permeable laser melted Ti6Al4V bone scaffolds

Arjunan

Demetriou

Baroutaji

et al. 2020

Journal of the Mechanical Behavior of Biomedical Materials

115

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Critically engineered stiffness and strength of a scaffold are crucial for managing maladapted stress concentration and reducing stress shielding. At the same time, suitable porosity and permeability are key to facilitate biological activities associated with bone growth and nutrient delivery. A systematic balance of all these parameters are required for the development of an effective bone scaffold. Traditionally, the approach has been to study each of these parameters in isolation without considering their interdependence to achieve specific properties at a certain porosity. The purpose of this study is to undertake a holistic investigation considering the stiffness, strength, permeability, and stress concentration of six scaffold architectures featuring a 68.46-90.98% porosity. With an initial target of a tibial host segment, the permeability was characterised using Computational Fluid Dynamics (CFD) in conjunction with Darcy's law. Following this, Ashby's criterion, experimental tests, and Finite Element Method (FEM) were employed to study the mechanical behaviour and their interdependencies under uniaxial compression. The FE model was validated and further extended to study the influence of stress concentration on both the stiffness and strength of the scaffolds. The results showed that the pore shape can influence permeability, stiffness, strength, and the stress concentration factor of Ti6Al4V bone scaffolds. Furthermore, the numerical results demonstrate the effect to which structural performance of highly porous scaffolds deviate, as a result of the Selective Laser Melting (SLM) process. In addition, the study demonstrates that stiffness and strength of bone scaffold at a targeted porosity is linked to the pore shape and the associated stress concentration allowing to exploit the design freedom associated with SLM.

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Section: Discussionmentioning

confidence: 99%

Mechanical performance of highly permeable laser melted Ti6Al4V bone scaffolds

Arjunan

Demetriou

Baroutaji

et al. 2020

Journal of the Mechanical Behavior of Biomedical Materials

115

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“…During the development of biomaterials for bone and cartilage regeneration, it is necessary to not only create a scaffold that is biocompatible and biodegradable, but also contains suitable mechanical properties with interconnected pores [15] that supports the differentiation status of cells, as well as the differentiation of stem cells into osteocytes and chondrocytes [56]. It is sometimes not possible to prepare a biomaterial with these desired properties using only one polymer.…”

Section: Bone and Cartilage Regenerationmentioning

confidence: 99%

Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine

et al. 2019

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Over the last few decades, chitosan has become a good candidate for tissue engineering applications. Derived from chitin, chitosan is a unique natural polysaccharide with outstanding properties in line with excellent biodegradability, biocompatibility, and antimicrobial activity. Due to the presence of free amine groups in its backbone chain, chitosan could be further chemically modified to possess additional functional properties useful for the development of different biomaterials in regenerative medicine. In the current review, we will highlight the progress made in the development of chitosan-containing bioscaffolds, such as gels, sponges, films, and fibers, and their possible applications in tissue repair and regeneration, as well as the use of chitosan as a component for drug delivery applications.

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“…Natural Polymer-Cell bioconstructs are used for bone tissue engineering [24]. Bioconstructs substitute the functionality of damaged natural bone structures if critical-sized defects occur.…”

Section: Bone Engineeringmentioning

confidence: 99%

Role of Calcium Bio-Minerals in Regenerative Medicine and Tissue Engineering

Upadhyay¹

2017

JSRT

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Present review article emphasize role of biominerals in regenerative medicine and tissue engineering. Among all biominerals calcium is essential for body growth and development. It also performs many fundamental functions in cellular metabolism. Inside cell organic matrix is calcified by calcium phosphate minerals. It also embeds bone cells which participate in the maintenance and organization of bone. This article also emphasizes use of hydroxyapatite a natural mineral used as a bone-building supplement with superior absorption in comparison to calcium. It also explains use of scaffolds that mimic the structure and composition of bone tissue and cells. It also signifies use of HAc microparticles or microparticles loaded with PL, superparamagnetic iron oxide nanoparticles, composite scaffolds of nano-hydroxyapatite (nHAp) and silk fibroin (SF) in bone regeneration mainly in osteoregenerative therapy. For better and successful bone regeneration there is a need to develop low cost sintered hydroxyfluorapatite discs to support cellular proliferation and colonization, tailored mineralization, cell and drug delivery. All adhesion components should show low immunoreactivity and high biocompatibility with natural bone tissues. There is an essential need to make new biocompatible materials for scaffolding, biomeinerals and cementing formulations for regeneration of bones, craniomaxillofacial, dental and orthopedic surgery.

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Natural Polymer-Cell Bioconstructs for Bone Tissue Engineering

Cited by 32 publications

References 0 publications

Mechanical performance of highly permeable laser melted Ti6Al4V bone scaffolds

Mechanical performance of highly permeable laser melted Ti6Al4V bone scaffolds

Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine

Role of Calcium Bio-Minerals in Regenerative Medicine and Tissue Engineering

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