Natural plant extracts and prebiotic compounds as alternatives to antibiotics in broiler chicken diets in a necrotic enteritis challenge model

Vidanarachchi, J. K.; Mikkelsen, Lene Lind; Constantinoiu, Constantin; Choct, Mingan; Iji, Paul

doi:10.1071/an12374

Cited by 31 publications

(22 citation statements)

References 42 publications

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“…The Yeast and Sangrovit treated groups showed a significant decrease in the total coliform count of intestinal content in comparison to t he control group This result agreed with Natsir et al (2013); Vidanarachchi et al (2013) and Boka et al (2014). Table 7: The effect of dietary supplementation of Yeast and Sangrovit on the coliform bacterial count in healthy and E.coli experimentally infected groups at 4 and 6 weeks of age( means ± standard error (SE); n=20).…”

Section: Resultssupporting

confidence: 71%

Evaluation of Some Treatments for Coliform Infection in Chicken

Hasan

Youssef²,

Elakhras³

2020

Egyptian Academic Journal of Biological Sciences, B. Zoology

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This work was designed to investigate the effect of yeast(Saccharomyces cerevisiae) and Sangrovit as natural feed additives on chicken production performance, some hematological parameters, some biochemical parameters, histopathological examination of (liver and kidney) and total coliform count of intestinal content in normal and experimentally infected chickens with E.coli O 78. A total of 120 unsexed one-day-old, broiler chickens (Cobb) were randomly assigned to 6 treatment groups each of 20 as follows: G1 as the control; G2 received 0.3% Yeast supplement; G3 received 0.1% Sangrovit supplement; G4 infected by E.coli only; G5 infected by E.coli and treated by 0.3% Yeast and G6 infected by E.coli and treated by 0.1% Sangrovit. Our work revealed that Yeast and Sangrovit as feed additives have marked impacts on growth-promoting, immunomodulating and antimicrobial effects with no adverse effects on haematological and serum biochemical parameters and can contribute in controlling and prevention of E.coli induced experimental infection in broiler chicken.

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Section: Resultssupporting

confidence: 71%

Evaluation of Some Treatments for Coliform Infection in Chicken

Hasan

Youssef²,

Elakhras³

2020

Egyptian Academic Journal of Biological Sciences, B. Zoology

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“…Liu et al [ 152 ] found that dietary supplementation of exogenous lysozyme decreased the C. perfringens colonization and improved the intestinal barrier function of chickens. Furthermore, it was demonstrated that a prebiotic product (arabinogalactan Fibregum) was effective in controlling NE [ 153 ].…”

Section: Restoration Of the Impaired Barrier Functionmentioning

confidence: 99%

Enteric Pathogens and Their Toxin-Induced Disruption of the Intestinal Barrier through Alteration of Tight Junctions in Chickens

Awad

Heß

2017

Toxins

300

241

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Maintaining a healthy gut environment is a prerequisite for sustainable animal production. The gut plays a key role in the digestion and absorption of nutrients and constitutes an initial organ exposed to external factors influencing bird’s health. The intestinal epithelial barrier serves as the first line of defense between the host and the luminal environment. It consists of a continuous monolayer of intestinal epithelial cells connected by intercellular junctional complexes which shrink the space between adjacent cells. Consequently, free passing of solutes and water via the paracellular pathway is prevented. Tight junctions (TJs) are multi-protein complexes which are crucial for the integrity and function of the epithelial barrier as they not only link cells but also form channels allowing permeation between cells, resulting in epithelial surfaces of different tightness. Tight junction’s molecular composition, ultrastructure, and function are regulated differently with regard to physiological and pathological stimuli. Both in vivo and in vitro studies suggest that reduced tight junction integrity greatly results in a condition commonly known as “leaky gut”. A loss of barrier integrity allows the translocation of luminal antigens (microbes, toxins) via the mucosa to access the whole body which are normally excluded and subsequently destroys the gut mucosal homeostasis, coinciding with an increased susceptibility to systemic infection, chronic inflammation and malabsorption. There is considerable evidence that the intestinal barrier dysfunction is an important factor contributing to the pathogenicity of some enteric bacteria. It has been shown that some enteric pathogens can induce permeability defects in gut epithelia by altering tight junction proteins, mediated by their toxins. Resolving the strategies that microorganisms use to hijack the functions of tight junctions is important for our understanding of microbial pathogenesis, because some pathogens can utilize tight junction proteins as receptors for attachment and subsequent internalization, while others modify or destroy the tight junction proteins by different pathways and thereby provide a gateway to the underlying tissue. This review aims to deliver an overview of the tight junction structures and function, and its role in enteric bacterial pathogenesis with a special focus on chickens. A main conclusion will be that the molecular mechanisms used by enteric pathogens to disrupt epithelial barrier function in chickens needs a much better understanding, explicitly highlighted for Campylobacter jejuni, Salmonella enterica and Clostridium perfringens. This is a requirement in order to assist in discovering new strategies to avoid damages of the intestinal barrier or to minimize consequences from infections.

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“…The functional competence and metabolic profile of body fluids and tissues can change in response to feed additives used. Reviews published recently have highlighted herbal plants as dietary supplements (26), among them alfalfa preparation (2,3). Recent studies have underlined its effectiveness on sheep (21,29), turkeys (19), laying hens (12), broiler chickens (8), and finally, pigs (14,15,22), where low alfalfa protein concentrate (APC) supplementation in the 2% -3% range caused higher weight gains and better feed conversion.…”

Section: Introductionmentioning

confidence: 99%

“…Its utility can be evaluated on the basis of swine performance and blood metabolic profile (10). Some authors (26,31) indicate alternate periods of supply and withdrawal of phytogenic preparations because of the manner of their metabolising and the effect of numerous biologically active compounds on the gastrointestinal tract microbiome as well as the blood metabolic profile in humans and animals. In the available sources, there are only few data on the effectiveness of APC on swine performance and health and therefore further studies are still needed in this area.…”

Section: Introductionmentioning

confidence: 99%

Influence of alfalfa protein concentrate dietary supplementation on blood parameters of growing-finishing pigs

Pietrzak

Grela

2015

Bulletin of the Veterinary Institute in Pulawy

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The aim of the study was to analyse the effect of the feed additive alfalfa protein concentrate (APC), on pig health. The trial involved 40 crossbred gilts and 40 crossbred castrates (Polish Landrace × Polish Large White) × Duroc of 29.0 ± 0.5 kg initial body weight. Allocation of experimental animals was into four treatment groups: the control group (C) was fed standard mixtures, without APC addition; group E-15 was fed a basal diet supplemented with 1.5% APC; and groups E-30 and E-30P were fed diets with 3.0% APC inclusion. There were two feeding systems. In the first system, animals of groups C, E-15, and E-30 were fed continuously with suitable mixtures. The second feeding system was used in group E-30P where animals received the experimental or control mixture alternating at two-week intervals. The addition of APC supplement to diets significantly increased (P ≤ 0.05) red blood cell indices, i.e. haematocrit (Ht), red blood cell count (RBC), and haemoglobin concentration (Hb) in growing and finishing periods. The analysis of enzyme activity demonstrated a markedly higher activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and especially alkaline phosphatase (ALP) in the blood plasma of pigs fed APC supplement. This increase may indicate a negative impact of APC on the animal's liver. A positive effect of dietary APC on blood lipid parameters was associated with a decreased level of total cholesterol and reduced low-density lipoprotein fraction. Analysis of the haematological and biochemical blood indices demonstrated that APC additive may affect animal health.

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Natural plant extracts and prebiotic compounds as alternatives to antibiotics in broiler chicken diets in a necrotic enteritis challenge model

Cited by 31 publications

References 42 publications

Evaluation of Some Treatments for Coliform Infection in Chicken

Evaluation of Some Treatments for Coliform Infection in Chicken

Enteric Pathogens and Their Toxin-Induced Disruption of the Intestinal Barrier through Alteration of Tight Junctions in Chickens

Influence of alfalfa protein concentrate dietary supplementation on blood parameters of growing-finishing pigs

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