Natural phenylpropanoids inhibit lipoprotein-induced endothelin-1 secretion by endothelial cells

Martin-Nizard, Françoise; Şahpaz, Sevser; Kandoussi, Abdelmejid; Carpentier, Marie; Fruchart, Jean‐Charles; Duriez, Patrick; Bailleul, François

doi:10.1211/0022357045048

Cited by 21 publications

(11 citation statements)

References 27 publications

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“…This protective effect can be mainly attributed to the free radical scavenging property of the PhGs. Furthermore, the inhibition of copper-oxidized LDL-induced endothelin-1 liberation by acteoside, forsythoside B, arenarioside, and ballotetroside (95) indicates that these PhGs may be potential therapeutic tools for controlling atherosclerosis [71]. In another study by He et al, acteoside, 2'-acetylacteoside, poliumoside, and brandioside from…”

Section: Effects On the Cardiovascular Systemmentioning

confidence: 99%

Naturally Occurring Phenylethanoid Glycosides: Potential Leads for New Therapeutics

Fu¹,

Pang²,

Wong

2008

CMC

133

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ABATRACTNatural products have long been regarded as excellent sources for drug discovery given their structure diversity and wide variety of biological activities. Phenylethanoid glycosides are naturally occurring compounds of plant origin and are structurally characterized with a hydroxyphenylethyl moiety to which a glucopyranose is linked through a glycosidic bond. To date several hundred compounds of this type have been isolated from medicinal plants and further pharmacological studies in vitro or in vivo have shown that these compounds possess a broad array of biological activities including antibacterial, antitumor, antiviral, anti-inflammatory, neuro-protective, antioxidant, hepatoprotective, immunomodulatory, and tyrosinase inhibitory actions. Given their extensive activity profile, structure-activity relationships analyses of these compounds have been performed in a number of studies to reveal potential leads for future drug design. This article will summarize the major developments in phenylethanoid glycosides-based research in the past decade. The progresses made in phytochemistry and biological activity studies of these compounds will be reviewed. Particular attention will be given to the novel structures identified to date and the prominent therapeutic values associated with these molecules.

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Section: Effects On the Cardiovascular Systemmentioning

confidence: 99%

Naturally Occurring Phenylethanoid Glycosides: Potential Leads for New Therapeutics

Fu¹,

Pang²,

Wong

2008

CMC

133

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“…In human endothelial cells in culture, PPAR α ligands inhibit the cytokine/LPS induction of COX-2 [38, 69], ICAM-1 [91], VCAM-1 [29, 31], endothelin-1 [92], IL-6, and prostaglandin E 2 [32, 93]. Similarly, PPAR α ligands repress thrombin-induced expression of endothelin-1 [32].…”

Section: Pparα and Pparγ: Anticancer Targets In The Endotheliummentioning

confidence: 99%

The Role of PPARs in the Endothelium: Implications for Cancer Therapy

Bishop‐Bailey

Swales

2008

PPAR Research

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The growth and metastasis of cancers intimately involve the vasculature and in particular the endothelial cell layer. Tumours require new blood vessel formation via angiogenesis to support growth. In addition, inflammation, coagulation, and platelet activation are common signals in the growth and metastasis of tumour cells. The endothelium plays a central role in the homeostatic control of inflammatory cell recruitment, regulating platelet activation and coagulation pathways. PPARα, -β/δ, and -γ are all expressed in endothelial cells. This review will discuss the roles of PPARs in endothelial cells in relation to angiogenesis, inflammation, coagulation, and platelet control pathways. In particular, we will discuss the recent evidence that supports the hypothesis that PPARα and PPARγ are antiangiogenic receptors, while PPARβ/δ is proangiogenic.

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“…A study by Jiang et al (16) showed that forsythiaside reduced serum levels of TNF-α and IL-6, decreased the infiltration of leukocytes and reduced the histopathological damage in a rat myocardial ischemia-reperfusion (I/R) model. In addition, Forsythiaside has been demonstrated to attenuate lipid peroxidation, decrease lipoprotein-induced endothelin-1 secretion by endothelial cells and inhibit COX-2 activity (17–19). However, the effect of forsythiaside on the inflammatory cytokine production induced by LPS in broiler chickens has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Forsythiaside attenuates lipopolysaccharide-induced inflammatory responses in the bursa of Fabricius of chickens by downregulating the NF-κB signaling pathway

Cheng

Zhao

et al. 2013

Experimental and Therapeutic Medicine

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Forsythiaside, a phenylethanoside product isolated from air-dried fruits of Forsythia suspensa, has been demonstrated to exhibit antioxidant, antibacterial and anti-inflammatory activities in vitro. However, its mechanism and the effects of lipopolysaccharide (LPS)-induced injury on the bursa of Fabricius (BF) of chickens are poorly understood. The present study aimed to investigate the anti-inflammatory effects of forsythiaside on LPS-induced acute inflammation. In addition, the potential molecular mechanisms of forsythiaside were analyzed in the BF, a special immune organ in chickens. Forty 15-day-old chickens were randomly divided into control, LPS and LPS plus forsythiaside (30 or 60 mg/kg) groups (n=10 for each group). In the LPS plus forsythiaside (30 or 60 mg/kg) groups, the chickens were orally administered with forsythiaside at doses of 30 and 60 mg/kg for seven days. At 21 days old, the chickens were intravenously injected with 200 μg/kg body weight LPS. Chickens in the control and LPS groups were only administered with vehicle or LPS, respectively, at day 21. At 3 h post-injection, the body temperature and nitric oxide (NO) levels were analyzed. In addition, the levels and mRNA expression of pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and IL-1β, and the mRNA expression of nuclear factor-κB (NF-κB), cyclooxygenase-2 (COX-2) and inducible NO synthase (iNOS), were examined in the BFs isolated from the chickens. The results revealed that forsythiaside was able to attenuate the LPS-induced inflammatory responses in the BFs of the chickens. The mechanisms by which forsythiaside exerted its anti-inflammatory effect were found to correlate with the inhibition of IL-6, IL-1β, TNF-α and COX-2 production, via the inactivation of NF-κB, indicating that the NF-κB-iNOS-NO signaling pathway may be important in this process.

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Natural phenylpropanoids inhibit lipoprotein-induced endothelin-1 secretion by endothelial cells

Cited by 21 publications

References 27 publications

Naturally Occurring Phenylethanoid Glycosides: Potential Leads for New Therapeutics

Naturally Occurring Phenylethanoid Glycosides: Potential Leads for New Therapeutics

The Role of PPARs in the Endothelium: Implications for Cancer Therapy

Forsythiaside attenuates lipopolysaccharide-induced inflammatory responses in the bursa of Fabricius of chickens by downregulating the NF-κB signaling pathway

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