Natural peptides for immunological regulation in cancer therapy: Mechanism, facts and perspectives

Zhang, Yunchao; Liu, Chenxin; Wu, Chunjie; Song, Linjiang

doi:10.1016/j.biopha.2023.114257

Cited by 24 publications

(13 citation statements)

References 169 publications

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“…Several cutting-edge nanovaccines exhibit considerable promise for cancer immunotherapy, including personalized vaccines [ 134 ], cytomembrane nanovaccines [ 385 ], peptide-based vaccines [ 386 , 387 ] and nanodiscs [ 388 , 389 ]. These new nanovaccine strategies might revolutionize or improve cancer immunotherapy.…”

Section: Challenges and Future Directionsmentioning

confidence: 99%

The quest for nanoparticle-powered vaccines in cancer immunotherapy

Sun,

Zhao,

et al. 2024

J Nanobiotechnol

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Despite recent advancements in cancer treatment, this disease still poses a serious threat to public health. Vaccines play an important role in preventing illness by preparing the body's adaptive and innate immune responses to combat diseases. As our understanding of malignancies and their connection to the immune system improves, there has been a growing interest in priming the immune system to fight malignancies more effectively and comprehensively. One promising approach involves utilizing nanoparticle systems for antigen delivery, which has been shown to potentiate immune responses as vaccines and/or adjuvants. In this review, we comprehensively summarized the immunological mechanisms of cancer vaccines while focusing specifically on the recent applications of various types of nanoparticles in the field of cancer immunotherapy. By exploring these recent breakthroughs, we hope to identify significant challenges and obstacles in making nanoparticle-based vaccines and adjuvants feasible for clinical application. This review serves to assess recent breakthroughs in nanoparticle-based cancer vaccinations and shed light on their prospects and potential barriers. By doing so, we aim to inspire future immunotherapies for cancer that harness the potential of nanotechnology to deliver more effective and targeted treatments. Graphical abstract

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Section: Challenges and Future Directionsmentioning

confidence: 99%

The quest for nanoparticle-powered vaccines in cancer immunotherapy

Sun,

Zhao,

et al. 2024

J Nanobiotechnol

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“…Like preventative anti-infectious vaccines, therapeutic cancer vaccines use patient and specific tumor antigen adjuvants to enhance the immune response. Tumor antigens include tumor-associated antigens, such as oncofetal antigens, oncoviral antigens, and neoantigens, which are usually derived from somatic mutations that characterize abnormal gene expression products, holding the high hope of inducing T-cell tumor-specific responses 14 , 29 , 30 . Tumor antigens can be made into tumor vaccines through a variety of candidate vaccine platforms, including DNA, RNA, peptides, DCs, and viral vectors 31 .…”

Section: Bio-clinical Context For Using Immune Adjuvants In Cancermentioning

confidence: 99%

“…Seventy-three clinical trials were referred to the NCI clinical.gov site 36 . Various immune adjuvants are being tested, most of which are derived from natural components, to reverse the suppressive TME to an anti-TME or to enhance the cancer vaccine-mediated immune response 29 . QS-21 is one of the active fractions from the bark of the Chilean tree, Quillaja saponaria , that is mainly used in different vaccine therapies for various cancers, including prostate cancer, breast cancer, and small cell lung carcinoma 37 .…”

Section: Bio-clinical Context For Using Immune Adjuvants In Cancermentioning

confidence: 99%

“…Other molecules include alun (alhydrogel or aluminium hydroxide gel) and GPI-0100, which have also been associated with different vaccines in advanced cancers. Some of the molecules were obtained from traditional Chinese medicines, such as Rhizoma bolbostemmatis , which were developed as immune adjuvants that modify the cancer microenvironment to heighten the anti-cancer response 29 , 35 , 37 , 38 .…”

Section: Bio-clinical Context For Using Immune Adjuvants In Cancermentioning

confidence: 99%

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Azoximer bromide and hydroxyapatite: promising immune adjuvants in cancer

Rossi,

Frayssinet,

Matciyak

et al. 2024

Cancer Biol Med

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Immune adjuvants are immune modulators that have been developed in the context of infectious vaccinations. There is currently a growing interest in immune adjuvants due to the development of immunotherapy against cancers. Immune adjuvant mechanisms of action are focused on the initiation and amplification of the inflammatory response leading to the innate immune response, followed by the adaptive immune response. The main activity lies in the support of antigen presentation and the maturation and functions of dendritic cells. Most immune adjuvants are associated with a vaccine or incorporated into the new generation of mRNA vaccines. Few immune adjuvants are used as drugs. Hydroxyapatite (HA) ceramics and azoximer bromide (AZB) are overlooked molecules that were used in early clinical trials, which demonstrated clinical efficacy and excellent tolerance profiles. HA combined in an autologous vaccine was previously developed in the veterinary field for use in canine spontaneous lymphomas. AZB, an original immune modulator derived from a class of heterochain aliphatic polyamines that is licensed in Russia, the Commonwealth of Independent States, and Slovakia for infectious and inflammatory diseases, is and now being developed for use in cancer with promising results. These two immune adjuvants can be combined in various immunotherapy strategies.

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“…In recent studies, peptides, especially bioactive peptides, are a hot spot in reversing the resistance of breast cancer cells to chemotherapeutic drugs. Peptide is an amino acid with a molecular weight between protein and small molecule ( Zhang et al, 2023 ). It is generally a short chain with more than 50 amino acids, usually containing a disulfide bond.…”

Section: Introductionmentioning

confidence: 99%

The role of peptides in reversing chemoresistance of breast cancer: current facts and future prospects

et al. 2023

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Breast cancer is the first malignant tumor in women, and its incidence is also increasing year by year. Chemotherapy is one of the standard therapies for breast cancer, but the resistance of breast cancer cells to chemotherapy drugs is a huge challenge for the effective treatment of breast cancer. At present, in the study of reversing the drug resistance of solid tumors such as breast cancer, peptides have the advantages of high selectivity, high tissue penetration, and good biocompatibility. Some of the peptides that have been studied can overcome the resistance of tumor cells to chemotherapeutic drugs in the experiment, and effectively control the growth and metastasis of breast cancer cells. Here, we describe the mechanism of different peptides in reversing breast cancer resistance, including promoting cancer cell apoptosis; promoting non-apoptotic regulatory cell death of cancer cells; inhibiting the DNA repair mechanism of cancer cells; improving the tumor microenvironment; inhibiting drug efflux mechanism; and enhancing drug uptake. This review focuses on the different mechanisms of peptides in reversing breast cancer drug resistance, and these peptides are also expected to create clinical breakthroughs in promoting the therapeutic effect of chemotherapy drugs in breast cancer patients and improving the survival rate of patients.

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Natural peptides for immunological regulation in cancer therapy: Mechanism, facts and perspectives

Cited by 24 publications

References 169 publications

The quest for nanoparticle-powered vaccines in cancer immunotherapy

The quest for nanoparticle-powered vaccines in cancer immunotherapy

Azoximer bromide and hydroxyapatite: promising immune adjuvants in cancer

The role of peptides in reversing chemoresistance of breast cancer: current facts and future prospects

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