Natural okra-based hydrogel for chronic diabetic wound healing

Xin, Peikun; Han, Shuyan; Huang, Jun; Zhou, Conglai; Zhang, Jiayuan; You, Xinru; Wu, Jun

doi:10.1016/j.cclet.2022.108125

Cited by 31 publications

(22 citation statements)

References 33 publications

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“…Macrophages are the main immune cells present in skin‐injury wounds, and their transition from the pro‐inflammatory M1 phenotype to the reparative M2 phenotype is crucial for inflammation resolution and wound repair. [ 7b,29 ] To investigate how the hydrogel influence macrophage polarization, we first used the in vitro macrophage immunofluorescence staining assay. Raw264.7 cells exposed solely toLPS were used as the control group in these experiments, while other groups were treated with hydrogel extracts following LPS exposure.…”

Section: Resultsmentioning

confidence: 99%

A Smart Stimulation–Deadhesion and Antimicrobial Hydrogel for Repairing Diabetic Wounds Infected with Methicillin‐Resistant Staphylococcus aureus

Bei,

Zhang,

et al. 2023

Adv Healthcare Materials

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The healing of chronic diabetic wounds is a common and significant challenge in the medical field. Despite extensive efforts, the development of hydrogel dressings with satisfactory functionality remains an ongoing concern. In this study, we present a multifunctional hydrogel wound dressing (PAN/Ag‐PLG) with adhesion, antibacterial, hemostatic, and other properties, which can effectively repair diabetic wounds infected with methicillin‐resistant Staphylococcus aureus (MRSA). The hydrogel dressing is composed of gallic acid‐functionalized polylysine‐reduced silver nanoparticles (Ag‐PLG), oxidized hyaluronic acid (OHA), and cross‐linked polyacrylic acid grafted with N‐hydrosuccinimide ester. Notably, compared to most conventional wound dressing that lack adhesion or are difficult to remove, our prepared hydrogels exhibit excellent adhesion and mild stimulation‐triggered detachment. In‐vitro and in‐vivo experiments revealed that the PAN/Ag‐PLG hydrogel exhibits outstanding biocompatibility and antibacterial properties and promotes diabetic wound repair by reducing oxidative damage and promoting cell migration and angiogenesis. The smart PAN/Ag‐PLG hydrogel reported in this study provides an approach for the potential clinical development of painless antibacterial dressings.This article is protected by copyright. All rights reserved

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Section: Resultsmentioning

confidence: 99%

A Smart Stimulation–Deadhesion and Antimicrobial Hydrogel for Repairing Diabetic Wounds Infected with Methicillin‐Resistant Staphylococcus aureus

Bei,

Zhang,

et al. 2023

Adv Healthcare Materials

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“…The hemolysis testing was based on our previous literature method with slight modification. , Deionized water (positive control group), sterile PBS buffer (negative control group), and 500 μL of CMS/Lap hydrogel extract were each added to 500 μL of 2% sheep erythrocyte suspension before they were cocultured in a 37 °C water bath for 3 h. Afterward, the samples were centrifuged at 3000 rpm for 20 min, and the supernatant of each group was transferred to a 96-well plate. The absorbance of the samples at 575 nm was measured by using a microplate reader.…”

Section: Methodsmentioning

confidence: 99%

Versatile Injectable Carboxymethyl Chitosan Hydrogel for Immediate Hemostasis, Robust Tissue Adhesion Barrier, and Antibacterial Applications

Guo,

Shen,

et al. 2023

ACS Appl. Mater. Interfaces

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Iatrogenic ulcers resulting from endoscopic submucosal dissection surgery remain a significant clinical concern due to the risk of uncontrolled bleeding. Herein, we have developed an injectable shear-thinning hydrogel cross-linked through electrostatic interactions and hydrogen bonding. The hydrogel underwent comprehensive characterization, focusing on rheological behavior, injectability, microstructure, film-forming capability, adhesion, swelling behavior, degradation kinetics, antibacterial efficacy, hemostatic performance, and biocompatibility. The incorporation of poly(vinyl alcohol) notably enhanced the internal structural stability and injection pressure, while the Laponite content influenced self-healing ability, modulus, and viscosity. Additionally, the hydrogel exhibited pH sensitivity, appropriate degradation, and swelling rates and displayed favorable film-forming and adhesion properties. Notably, it demonstrated excellent resistance against Escherichia coli and Staphylococcus aureus, highlighting its potential to create an optimal wound environment. In vivo studies further confirmed the hydrogel's exceptional hemostatic performance, positioning it as an optimal material for endoscopic submucosal dissection (ESD) surgery. Moreover, cell experiments and hemolysis tests revealed high biocompatibility, supporting their potential to facilitate the healing of iatrogenic ulcers post-ESD surgery. In conclusion, our hydrogels hold great promise as endoscopic treatment materials for ESD-induced ulcers given their outstanding properties.

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“…These properties can support hydrogels as excellent carriers for inducing cell proliferation or differentiation and internal environment homeostasis in endometrial injury. [300][301][302] Hydrogels have recently found extensive application in bone repair, 303 cardiovascular scaffolds, 304 vascular regeneration, [305][306][307] and skin excipients. 308 The exceptional properties of hydrogels enable them to serve as carriers for estrogens, active substances, drugs, and stem cells, facilitating their transportation into the uterine cavity.…”

Section: Requirements Of Biomedical Hydrogelsmentioning

confidence: 99%

Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions

Hu,

Wu,

Yong

et al. 2023

MedComm

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The endometrium is a unique human tissue with an extraordinary ability to undergo a hormone‐regulated cycle encompassing shedding, bleeding, scarless repair, and regeneration throughout the female reproductive cycle. The cyclical repair and regeneration of the endometrium manifest as changes in endometrial epithelialization, glandular regeneration, and vascularization. The mechanisms encompass inflammation, coagulation, and fibrinolytic system balance. However, specific conditions such as endometriosis or TCRA treatment can disrupt the process of cyclical endometrial repair and regeneration. There is uncertainty about traditional clinical treatments' efficacy and side effects, and finding new therapeutic interventions is essential. Researchers have made substantial progress in the perspective of regenerative medicine toward maintaining cyclical endometrial repair and regeneration in recent years. Such progress encompasses the integration of biomaterials, tissue‐engineered scaffolds, stem cell therapies, and 3D printing. This review analyzes the mechanisms, diseases, and interventions associated with cyclical endometrial repair and regeneration. The review discusses the advantages and disadvantages of the regenerative interventions currently employed in clinical practice. Additionally, it highlights the significant advantages of regenerative medicine in this domain. Finally, we review stem cells and biologics among the available interventions in regenerative medicine, providing insights into future therapeutic strategies.

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Natural okra-based hydrogel for chronic diabetic wound healing

Cited by 31 publications

References 33 publications

A Smart Stimulation–Deadhesion and Antimicrobial Hydrogel for Repairing Diabetic Wounds Infected with Methicillin‐Resistant Staphylococcus aureus

A Smart Stimulation–Deadhesion and Antimicrobial Hydrogel for Repairing Diabetic Wounds Infected with Methicillin‐Resistant Staphylococcus aureus

Versatile Injectable Carboxymethyl Chitosan Hydrogel for Immediate Hemostasis, Robust Tissue Adhesion Barrier, and Antibacterial Applications

Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions

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