Natural nodular worm infection in goats induces eosinophil extracellular DNA trap (EET) formation

Anisuzzaman, Anisuzzaman; Anas, Abu; Yasin, Md. Golam; Labony, Sharmin Shahid; Hossain, Md. Mokbul; Begum, Nurjahan; Hatta, Takeshi; Tsuji, Naotoshi; Alim, Md. Abdul

doi:10.1016/j.parint.2020.102178

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…However, no killing was observed in this model. Such trapping without killing has been demonstrated for numerous helminth species, both of human and agricultural importance, such as H. contortus ( 72 , 73 ), B. malayi ( 74 ), Dirofilaria immitis ( 75 ), Onchocerca volvulus ( 76 ), Ostertagia ostertagi ( 77 ), Fasciola hepatica ( 78 ), Oesophagostomum columbianum ( 79 ), and E. granulosus ( 80 ). Interestingly, it was reported that human neutrophils do not release NETs when stimulated by S. mansoni eggs but do when stimulated by S. japonicum eggs ( 81 ).…”

Section: Evidence For Myeloid Cell Killing and Control Of Infectionmentioning

confidence: 99%

How to train your myeloid cells: a way forward for helminth vaccines?

Doolan,

Putananickal,

Tritten

et al. 2023

Front. Immunol.

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Soil-transmitted helminths affect approximately 1.5 billion people worldwide. However, as no vaccine is currently available for humans, the current strategy for elimination as a public health problem relies on preventive chemotherapy. Despite more than 20 years of intense research effort, the development of human helminth vaccines (HHVs) has not yet come to fruition. Current vaccine development focuses on peptide antigens that trigger strong humoral immunity, with the goal of generating neutralizing antibodies against key parasite molecules. Notably, this approach aims to reduce the pathology of infection, not worm burden, with only partial protection observed in laboratory models. In addition to the typical translational hurdles that vaccines struggle to overcome, HHVs face several challenges (1): helminth infections have been associated with poor vaccine responses in endemic countries, probably due to the strong immunomodulation caused by these parasites, and (2) the target population displays pre-existing type 2 immune responses to helminth products, increasing the likelihood of adverse events such as allergy or anaphylaxis. We argue that such traditional vaccines are unlikely to be successful on their own and that, based on laboratory models, mucosal and cellular-based vaccines could be a way to move forward in the fight against helminth infection. Here, we review the evidence for the role of innate immune cells, specifically the myeloid compartment, in controlling helminth infections. We explore how the parasite may reprogram myeloid cells to avoid killing, notably using excretory/secretory (ES) proteins and extracellular vesicles (EVs). Finally, learning from the field of tuberculosis, we will discuss how anti-helminth innate memory could be harnessed in a mucosal-trained immunity-based vaccine.

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Section: Evidence For Myeloid Cell Killing and Control Of Infectionmentioning

confidence: 99%

How to train your myeloid cells: a way forward for helminth vaccines?

Doolan,

Putananickal,

Tritten

et al. 2023

Front. Immunol.

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“…Inflammation plays a vital role in host defence against attacking pathogens. In response to an infection, a cascade of signals first activates innate immune systems consisting of neutrophils, macrophages, eosinophils or mast cells, which phagocytose infectious agents or kill them by releasing chemical mediators [5,6]. Microbially induced inflammation is elicited by structural moieties found on or released by microorganisms, which are known as pathogen-associated molecular patterns (PAMPs).…”

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confidence: 99%

Receptor for Advanced Glycation End Product (RAGE) Modulates Inflammation During Feeding of the Hard Tick, Haemaphysalis longicornis in Mice

Anisuzzaman,

Alim,

Matsubyashi

et al. 2024

Parasite Immunology

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Ticks are notorious blood‐sucking ectoparasites that affect both humans and animals. They serve as a unique vector of various deadly diseases. Here, we have shown the roles of the receptor for advanced glycation end products (RAGE) during repeated infestations by the tick Haemaphysalis longicornis using RAGE−/− mice. In primary infestation, a large blood pool developed, which was flooded with numerous RBCs, especially during the rapid feeding phase of the tick both in wild‐type (wt) and RAGE−/− mice. Very few inflammatory cells were detected around the zones of haemorrhage in the primary infestations. However, the number of inflammatory cells gradually increased in the subsequent tick infestations, and during the third infestations, the number of inflammatory cells reached to the highest level (350.3 ± 16.8 cells/focus). The site of attachment was totally occupied by the inflammatory cells in wt mice, whereas very few cells were detected at the ticks' biting sites in RAGE−/− mice. RAGE was highly expressed during the third infestation in wt mice. In the third infestation, infiltration of CD44+ lymphocytes, eosinophils and expression of S100A8 and S100B significantly increased at the biting sites of ticks in wt, but not in RAGE−/− mice. In addition, peripheral eosinophil counts significantly increased in wt but not in RAGE−/− mice. Taken together, our study revealed that RAGE‐mediated inflammation and eosinophils played crucial roles in the tick‐induced inflammatory reactions.

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Natural nodular worm infection in goats induces eosinophil extracellular DNA trap (EET) formation

Cited by 2 publications

References 25 publications

How to train your myeloid cells: a way forward for helminth vaccines?

How to train your myeloid cells: a way forward for helminth vaccines?

Receptor for Advanced Glycation End Product (RAGE) Modulates Inflammation During Feeding of the Hard Tick, Haemaphysalis longicornis in Mice

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