Natural medicinal plant products as an immune-boosters: A possible role to lessen the impact of Covid-19

Islam, Sk Saruk; Midya, Sujoy; Sinha, Sanjit; Saadi, Sk Md Abu Imam

doi:10.1016/j.cscee.2021.100105

Cited by 14 publications

(8 citation statements)

References 76 publications

(96 reference statements)

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“…In this series, the entire tulsi plant is useful for the immunomodulatory effect. The myricetin and scutellarein found in tulsi potentially inhibited SARS-COV helicase by inhibition of ATPase activity ( Islam et al, 2021 ). Scutellarein is a natural flavonoid obtained from tulsi.…”

Section: Antiviral and Immunomodulatory Mechanisms Of Recommended Bio...mentioning

confidence: 99%

“…Ayurveda intrusions become even more pertinent by the fact that there is a broad explanation of the causation and management of the COVID-19 pandemic in Ayurveda. The identification and the use of phytochemicals obtained from medicinal herbs could help to lower the infection rate and successfully have become a new approach for the treatment of viral SARS-COV-2 infection ( Anand et al, 2021 ; Islam et al, 2021 ). Some risk factors, for instance, age, diabetes, cardiac diseases, reduced oxygen level, and psychosis, are the chief hurdles seen in the treatment of SARS-COV-2.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An exhaustive comprehension of the role of herbal medicines in Pre- and Post-COVID manifestations

Prajapati¹,

Malaiya²,

Mishra³

et al. 2022

Journal of Ethnopharmacology

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Section: Antiviral and Immunomodulatory Mechanisms Of Recommended Bio...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An exhaustive comprehension of the role of herbal medicines in Pre- and Post-COVID manifestations

Prajapati¹,

Malaiya²,

Mishra³

et al. 2022

Journal of Ethnopharmacology

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“…Even direct precipitation, the sol-gel method, reverse micelles, thermal decomposition, or the solvothermal method was successfully used for the obtaining of metallic nanoparticles; "green methods" (with biological sources such as bacteria, fungi, yeast, actinobacteria, and plants) can be used as well (Figure 4). The recent pandemic of the COVID-19 virus has demonstrated that costs in both human life and economic terms can be very high if the spread of the infection is not controlled [76]. Therefore, it is very important to have measures to minimize this spread of infection.…”

Section: Application Of Brassica Genus In Green Nanotechnologymentioning

confidence: 99%

Sustainable Use of Cruciferous Wastes in Nanotechnological Applications

Ungureanu

Fierăscu

2022

Coatings

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Over the last few years, new nanoparticle preparation methods have emerged by replacing the usual reagents with plant extracts obtained in different conditions. An example of a natural plant extract is those of cruciferous vegetables, to obtain the new bio-nano-coatings. Given the composition of cruciferous extracts and large amounts of wastes produced all over the world, they can be successful substitutes to replace conventional coatings and extend the possibility of “smart coatings“. The present review aims to be a critical discussion regarding the application of cruciferous waste in nanotechnological applications. This review paper can be a starting report for different researchers who intend to use this sustainable approach “from green to nanotechnology” to transpose manufacturing from laboratory to industry. Applying this approach to obtain nanostructures with plant waste highlights the importance of minimizing and re-utilizing residues from primary and secondary processing via chemical and social intervention, in order to contribute to the sustainability needs of the planet and its inhabitants.

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“…Many natural products, particularly flavonoids, have been shown to inhibit the regulation of TMPRSS2, through an interesting binding with the active site of human TMPRSS2 (Omokhua-Uyi & Van Staden, 2021). This includes quercetin, luteolin, and kaempferol that have the capacity to suppress TMPRSS2 expression (Islam et al, 2021).…”

Section: Polyphenols Targeting Tmprss2mentioning

confidence: 99%

“…Seven coronaviruses have been discovered to be transmissible through human contact so far (Ezhilan et al, 2021), causing pneumonia-like symptoms (Wu et al, 2020).Among them, the two recent deadly forms are, SARS-CoV in China in 2002and MERS-CoV in Saudi Arabia in 2012(Boozari&Hosseinzadeh, 2021. In the 21st century, SARS-CoV-2 made history as the third coronavirus outbreak causing a dangerous disease called Covid-19 (coronavirus disease 2019) (Islam et al, 2021). The first appearance of this pathogen was in late November 2019 in Wuhan, China.…”

Section: Introductionmentioning

confidence: 99%

General overview on SARS-CoV-2 and potential role of natural compounds as antiviral drugs targeting SARS-CoV-2 proteins

Dassamiour

Ghebache

Garbi

2022

AGJSR

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Purpose: The novel coronavirus disease namely COVID-19 is a viral disease induced by severe acute respiratory syndrome coronavirus (SARS-CoV-2). The cases were first reported in Wuhan, China, by the end of 2019 and subsequently spread worldwide. The virus can be transferred through direct or indirect contact and leads to several manifestations; the most common are fever, dry cough, pneumonia, and acute respiratory distress syndrome (ARDS). COVID-19 has caused massive human and economic losses, posing an ongoing threat. Understanding the current situation and developing a treatment which can be both safe and effective has become essential. In this regard, natural products could be an important resource in the development of treatment for COVID-19, as they have contributed to the treatment of other viruses in the past. This review aims to understand the cellular machinery of SARS-CoV-2 and to identify its drug targets. Methods: Emphasis has been given on the literature survey based on in vitro, in vivo, and in silico studies of natural products as anti-SARS-CoV-2. The important role of these compounds in boosting the immune system was also highlighted. Results: It was found that some natural products showed prominent antiviral activity against coronaviruses through impeding the main machinery used in their pathogenesis and replication cycle. Based on in vitro, in vivo, and in silico investigations, several classes of secondary metabolites, particularly polyphenols, have the ability to disrupt the interaction between SARS-CoV-2 S protein and the ACE2 receptor, resulting in virus entry inhibition. As well as the ability to block the activity of several enzymes involved in the virus replication cycle, including, 3CLpro, PLpro and RdRp. On the other hand, several vitamins and minerals can improve the immune response and are useful for COVID-19 prevention. Essential oils also show the ability to disrupt the fluidity of the virus envelope. Conclusion: Many phytonutrients are counted as bioactive components against SARS-CoV-2, phenolic compounds by their potent mechanisms of action via the immune system rank first. Group B vitamins, vitamins A, C and E as well as minerals such as zinc, selenium and magnesium also play an important role in in preventing the attack by this virus.

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Natural medicinal plant products as an immune-boosters: A possible role to lessen the impact of Covid-19

Cited by 14 publications

References 76 publications

An exhaustive comprehension of the role of herbal medicines in Pre- and Post-COVID manifestations

An exhaustive comprehension of the role of herbal medicines in Pre- and Post-COVID manifestations

Sustainable Use of Cruciferous Wastes in Nanotechnological Applications

General overview on SARS-CoV-2 and potential role of natural compounds as antiviral drugs targeting SARS-CoV-2 proteins

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