Natural Lignans Honokiol and Magnolol as Potential Anticarcinogenic and Anticancer Agents. A Comprehensive Mechanistic Review

Mottaghi, Sayeh; Abbaszadeh, Hassan

doi:10.1080/01635581.2021.1931364

Cited by 36 publications

(19 citation statements)

References 156 publications

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“…Besides, MN and HK were shown to inhibit the protein expression of NF-κB, which was one of the major downstream targets of EGFR/PI3K and involved in a variety of processes, such as inflammatory, immune responses and MDR [ 32 , 33 , 34 , 35 ]. Therefore, our present results indicating that MN and HK inhibited EGFR/PI3K signaling pathway was in good agreements with these previous findings [ 29 , 30 , 31 ].…”

Section: Discussionsupporting

confidence: 93%

“…The present results showed that MN and HK inhibited the protein expressions of p-EGFR and p-PI3K, thereby inhibiting BCRP expression, indicating that MN and HK down-regulated BCRP via the EGFR/PI3K signaling pathway. Recently, MN and HK have been reported as promising anticarcinogenic and anticancer agents through inhibiting PI3K/AKT/mammalian target of rapamycin (mTOR) signaling pathway [ 29 ]. In addition, MN triggered the apoptosis of human prostate cancer cells by suppressing the EGFR/PI3K/AKT signaling pathway [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

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Magnolol and Honokiol Inhibited the Function and Expression of BCRP with Mechanism Exploration

Chen

et al. 2021

Molecules

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Breast cancer resistance protein (BCRP), one of the ATP-binding cassette (ABC) transporters, was associated with the multidrug resistance (MDR) of chemotherapy. Magnolol (MN) and honokiol (HK) are major bioactive polyphenols of Magnolia officinalis. This study investigated the effects of MN and HK on the function and expression of BCRP for the purpose of developing BCRP inhibitor to overcome MDR. Cell lines including MDCKII-BCRP and MDCKII-WT were used for evaluating the function and expression of BCRP. The results showed that MN (100–12.5 µM) and HK (100–12.5 µM) significantly decreased the function of BCRP by 80~12% and 67~14%, respectively. In addition, MN and HK were verified as substrates of BCRP. Furthermore, MN and HK reduced the protein expression of BCRP, and inhibited the phosphorylation of epidermal growth factor receptor (EGFR) and phosphatidylinositol 3-kinase (PI3K). In conclusion, both MN and HK decreased the function and expression of BCRP via EGFR/PI3K signaling pathway. Therefore, both compounds were promising candidates for reversing the MDR of chemotherapy.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Magnolol and Honokiol Inhibited the Function and Expression of BCRP with Mechanism Exploration

Chen

et al. 2021

Molecules

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“…Studies using purified magnolol have shown that it can have anti-inflammatory effects [6], anti-microbial activities [7], anti-oxidant effects [8], neuroprotection [9], cardiovascular protection [10], and anti-cancer properties [11]. Numerous previous in vitro and in vivo studies have demonstrated that magnolol has cancer chemo-preventive and inhibiting properties through different molecular mechanisms [11,12]. Jin et al reported that magnolol could suppress cell migration and induced cell apoptosis via the inhibition of the nuclear factor-κB (NF-κB) signaling pathway in human multiple myeloma cells [13].…”

Section: Introductionmentioning

confidence: 99%

Magnolol Triggers Caspase-Mediated Apoptotic Cell Death in Human Oral Cancer Cells through JNK1/2 and p38 Pathways

Chen

Lin

et al. 2021

Biomedicines

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Magnolol is a natural compound extracted from Chinese herbal medicine and can induce apoptosis in numerous types of cancer cells. However, the molecular mechanisms of magnolol in oral cancer are still unclear. In this study, we investigated the anti-cancer effects and underlying mechanisms of magnolol in human oral cancer cell lines. Our results exhibited that magnolol inhibited the cell proliferation via inducing the sub-G1 phase and cell apoptosis of HSC-3 and SCC-9 cells. The human apoptosis array and Western blot assay showed that magnolol increased the expression of cleaved caspase-3 proteins and heme oxygenase-1 (HO-1). Moreover, we proved that magnolol induces apoptosis in oral cancer cell lines via the c-Jun N-terminal kinase (JNK)1/2 and p38 pathways. Overall, the current study supports the role for magnolol as a therapeutic approach for oral cancer through JNK1/2- and p38-mediated caspase activation.

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“…Magnolol Figure 1a is a chemical compound classified in the specific group of polyphenols called lignans. Magnolol occurs in the bark of various types of magnolia, including: Magnolia officinals, Magnolia obovata, or Magnolia dealbata, and is often accompanied by another lignan, which is its optical isomer, honokiol Figure 1b [9][10][11][12]. In traditional Chinese medicine, magnolia bark is considered to have antipyretic, analgesic, sedative, constipating, anti-asthmatic, cardioprotective, vasoprotective, or antibacterial properties.…”

Section: Magnolol-a Brief Description Of a Chemical Compound Its Occurrence In Nature And The Most Important Activitiesmentioning

confidence: 99%

Effectiveness of Magnolol, a Lignan from Magnolia Bark, in Diabetes, Its Complications and Comorbidities—A Review

Szałabska-Rąpała

Borymska

Kaczmarczyk-Sedlak

2021

IJMS

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Diabetes mellitus is a chronic metabolic disease characterized by disturbances in carbohydrate, protein, and lipid metabolism, often accompanied by oxidative stress. Diabetes treatment is a complicated process in which, in addition to the standard pharmacological action, it is necessary to append a comprehensive approach. Introducing the aspect of non-pharmacological treatment of diabetes allows one to alleviate its many adverse complications. Therefore, it seems important to look for substances that, when included in the daily diet, can improve diabetic parameters. Magnolol, a polyphenolic compound found in magnolia bark, is known for its health-promoting activities and multidirectional beneficial effects on the body. Accordingly, the goal of this review is to systematize the available scientific literature on its beneficial effects on type 2 diabetes and its complications. Taking the above into consideration, the article collects data on the favorable effects of magnolol on parameters related to glycemia, lipid metabolism, or oxidative stress in the course of diabetes. After careful analysis of many scientific articles, it can be concluded that this lignan is a promising agent supporting the conventional therapies with antidiabetic drugs in order to manage diabetes and diabetes-related diseases.

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Natural Lignans Honokiol and Magnolol as Potential Anticarcinogenic and Anticancer Agents. A Comprehensive Mechanistic Review

Cited by 36 publications

References 156 publications

Magnolol and Honokiol Inhibited the Function and Expression of BCRP with Mechanism Exploration

Magnolol and Honokiol Inhibited the Function and Expression of BCRP with Mechanism Exploration

Magnolol Triggers Caspase-Mediated Apoptotic Cell Death in Human Oral Cancer Cells through JNK1/2 and p38 Pathways

Effectiveness of Magnolol, a Lignan from Magnolia Bark, in Diabetes, Its Complications and Comorbidities—A Review

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