Natural killing activity in patients with spontaneous regression of malignant lymphoma

Ono, Kazutoshi; Kikuchi, Masako; Funai, Noriko; Matsuzaki, Morio; Shimamoto, Yoshinori

doi:10.1007/bf01541669

Cited by 22 publications

(13 citation statements)

References 36 publications

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“…We have diagnosed SR of ML based on these results and no local recurrence for 7 years. These findings strongly suggest that activated CD8‐positive T cells might be one of the possible factors responsible for spontaneous regression of malignant lymphoma, as reported by Ono et al 15 …”

Section: Discussionsupporting

confidence: 83%

Spontaneous regression of malignant lymphoma of the breast

Iihara

Yamaguchi

Nishimura

et al. 2004

Pathology International

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A complete spontaneous regression of diffuse large B cell lymphoma involving the right breast, confirmed by aspiration cytology, is reported. The patient visited a hospital due to the rapid growth of a tumor in the right breast. Five years previously she underwent a craniotomy for a brain tumor, diagnosed as B-cell malignant lymphoma, and received several courses of irradiation to the brain. Analysis of the breast tumor cells obtained by aspiration revealed lymphoma cells morphologically, which were similar to the tumor cells in the brain expressing CD20. While waiting for further examination, the tumor regressed rapidly and was not palpable after 20 days. An excisional biopsy of the breast exhibited no definite malignant lymphoma cells among a diffuse population of CD45RO and CD8-positive small lymphocytes. Nucleotide sequencing of HCDR3s of the brain tumor and breast tumor cells showed a completely matched sequence, revealing the breast mass to be a metastatic lesion from the tumor of the brain. Although there was no tumorous lesion, the patient received additional chemotherapy and has shown no sign of recurrence in the breast for 7 years. We were able to confirm that the breast lymphoma shown in the aspiration cytology was a metastatic one, which was not proven histologically prior to chemotherapy, and regard the present case as a malignant lymphoma of the breast showing spontaneous regression. The present case shows a rare occurrence of spontaneous regression of diffuse large B cell malignant lymphoma after aspiration and suggests that CD8-positive T cells might be related to the regression.

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Section: Discussionsupporting

confidence: 83%

Spontaneous regression of malignant lymphoma of the breast

Iihara

Yamaguchi

Nishimura

et al. 2004

Pathology International

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“…These findings suggest that the immune reaction of the host to infectious pathogens may exert anticancer effects. Ono et al [15] described that augmentation of natural killer activity that accompanies viral infection may contribute to tumor regression. In our cases, no infectious pathogens, including EBV, HBV, and HCV, were associated with tumor remission.…”

Section: Discussionmentioning

confidence: 99%

Self-Limited Effusion Large B-Cell Lymphoma: Two Cases of Effusion Lymphoma Maintaining Remission after Drainage Alone

Nakatsuka¹,

Kimura²,

Nagano³

et al. 2013

Acta Haematol

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We report two cases of human herpesvirus-8 (HHV-8)-negative large B-cell lymphoma involving pericardial and/or pleural effusion that regressed after drainage alone. Case 1 is a 70-year-old man showing massive pericardial effusion. Cytology of the drained effusion showed monotonous infiltration of CD3-, CD20+, CD79a+, and CD138- large B-cells. Monoclonality was shown by Southern blot analysis. Case 2 is a 70-year-old man with massive pericardial and bilateral pleural effusion. Cytology of pericardial effusion showed infiltration of CD20+, CD45RO-, CD138-, immunoglobulin lambda chain+, and kappa chain- large B cells. In both cases, effusion resolved after drainage and no relapse has been observed. HHV-8 was not demonstrated in either case. Clinical presentation of our two cases resembled primary effusion lymphoma (PEL), but cytomorphology, immunophenotype, and prognosis were clearly distinct from those of PEL. HHV-8-negative effusion lymphomas might include prognostically favorable self-limited tumors that could regress without any cytotoxic therapy.

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“…The mechanism of spontaneous remission is not clear, but apoptosis seems to be a part of it [27]. There are many speculations as to what causes this apoptosis; some believe in immunological factors [28,29], like natural killing activity [30] or antibodies [31], while other speculate in a positive effect of fever [32], thyroid hormone stimulation [33], and surgery [34,35].…”

Section: Improving Coherence Quality Of Life and Survivalmentioning

confidence: 99%

Clinical Holistic Medicine: Metastatic Cancer

Ventegodt

Solheim²,

Saunte³

et al. 2004

The Scientific World JOURNAL

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We believe that the consciousness-based/holistic medical toolbox has a serious additional offer to cancer patients and, as a consequence, designed a treatment for the patient with metastasized cancer. From a holistic perspective, cancer can be understood as a simple disturbance of the cells, arising from the tissue holding on to a trauma with strong emotional content. This is called “a blockage”, where the function of the cells is allocated from their original function in the tissue to a function of holding emotions. We hope to be able not only to improve the quality of life, but also to improve survival and in some cases even induce spontaneous remission of the metastasized cancer. This paper describes how work with a patient with metastasized cancer can be done in the holistic clinical practice in 14 days on an individual basis, helping the patient to recover her human character, purpose of life, coherence, and will to live, thus improving quality of life and possibly also survival time. The holistic therapeutic work includes (1) teaching existential theory, (2) working with life perspective and philosophy of life, (3) helping the patient to acknowledge the state of the disease and the feelings connected to it, and finally (4) getting the patient into the holistic state of healing: (a) feeling old repressed emotions, (b) understanding why she got sick from a holistic point of view, and finally (c) letting go of the negative beliefs and decisions that made her sick according to the holistic theory of nongenetic diseases. The theory of the human character, the quality of life theories, the holistic theory of cancer, the holistic process theory of healing, the theory of (Antonovsky) coherence, and the life mission theory are the most important theories for the patient to find hope and mobilize the will to fight the cancer and survive. The patient went through the following phases: (1) finding the purpose of life and hidden resources; (2) confronting denial; (3) taking responsibility for being very ill; (4) severe existential crises with no wish to live while still fighting; (5) integration of many repressed feelings and negative decisions thus rehabilitating character; (6) confronting lack of intimacy and trust in others and this way rehabilitating the ability to love; (7) rehabilitating the will to live, breaking through and falling in love with life; (8) assuming responsibility for the social relations; and sometimes (9) quality of life is improved radically with indications of spontaneous remission of the liver tumors.

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Natural killing activity in patients with spontaneous regression of malignant lymphoma

Cited by 22 publications

References 36 publications

Spontaneous regression of malignant lymphoma of the breast

Spontaneous regression of malignant lymphoma of the breast

Self-Limited Effusion Large B-Cell Lymphoma: Two Cases of Effusion Lymphoma Maintaining Remission after Drainage Alone

Clinical Holistic Medicine: Metastatic Cancer

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