Natural killer NKG2A and NKG2D serum levels in patients with colorectal cancer

Abstract

metastases in multiple organs or locations. Correlations between the location, number, and SUVmax of metastatic lesions and overall survival (OS) were evaluated. Results: Of 136 patients, hepatic metastasis was found in 104, pulmonary metastasis in 36, distant lymph node metastasis in 18, peritoneal metastasis in 15, and bone metastasis in 13. The SUVmax range for metastatic lesions was 4-9.9 (mean 7.8; median 7.5). According to the sub-classification, groups I, II, and III were consisted of 35, 58, and 43 patients, respectively. The patients without bone and distant lymph node metastasis, with metastatic lesion of SUVmax <7.5, from groups I and II had significantly longer OS compared with those of the patients with bone and distant lymph node metastasis, with metastatic lesion of SUVmax 7.5, and from group III. Moreover, multivariate analysis showed that bone metastasis and higher SUVmax of metastatic lesion ( 7.5) were independent prognostic factors for OS. Conclusions: The presence of bone metastasis and high SUVmax of metastatic lesion in staging PET/CT might have prognostic value in predicting the survival of mCRC patients.