Natural Killer (NK) Cell Receptors' Repertoire in Couples with Recurrent Spontaneous Abortions

Varla-Leftherioti, M.; Spyropoulou-Vlachou, Maria; Niokou, Demetra; Keramitsoglou, Theodora; Darlamitsou, Areti; Tsekoura, Christina; Papadimitropoulos, Miltiadis; Lepage, V.; Balafoutas, Christos; Stavropoulos-Giokas, Catherine

doi:10.1034/j.1600-0897.2003.00018.x

Cited by 90 publications

(58 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…RSA patients seem to show a higher prevalence of B haplotypes when compared with A haplotypes, and individuals with BB genotypes might be at a greater risk for spontaneous miscarriages than those having AA or AB genotypes [61,62].…”

Section: Nk Cells: Harmful In Pregnancy?mentioning

confidence: 96%

NK Cells, Autoantibodies, and Immunologic Infertility: A Complex Interplay

Carolis

Perricone

2009

Clinic Rev Allerg Immunol

View full text Add to dashboard Cite

Infertility and recurrent spontaneous abortion (RSA) are heterogeneous conditions that have been frequently explained with an immunological pathomechanism. A deeper insight into apparently unexplained infertility and RSA shows increasing evidences supporting both alloimmune and autoimmune mechanisms, in which natural killer (NK) cells and autoantibodies seem to play a relevant role. Successful pregnancy is considered as Th1-Th2 cooperation phenomenon, with a predominantly Th2-type lymphocytes response, together with the emerging role of interleukin (IL)-12, IL-15, and IL-18 and of other unidentified soluble factors dependent on NK cells. Uterine NK cells comprise the largest population at implantation site, and their activity, characteristics, and abundance suggest that they participate at the "decidualization" process that, vice versa, induces NK activation and recruitment in each menstrual cycle. However, NK cell alteration may be associated with impaired pregnancy, and the modulation in the number of circulating NK cells is most likely to be a primary event rather than an active inflammation/drug administration consequence during an inflammatory/autoimmune process, thus playing an important role in the pathogenesis of immunological infertility. Relationships within immunological infertility, recurrent spontaneous abortion, autoantibodies, and NK cells will be reviewed herein.

show abstract

Section: Nk Cells: Harmful In Pregnancy?mentioning

confidence: 96%

NK Cells, Autoantibodies, and Immunologic Infertility: A Complex Interplay

Carolis

Perricone

2009

Clinic Rev Allerg Immunol

View full text Add to dashboard Cite

show abstract

“…Studies of NKR polymorphism and the HLA-C alleles expressed on the trophoblasts aimed at uncovering the consequences that the various combinations might have on pregnancy outcome have been reported. In one preliminary study, 26 childless couples with two or greater incidences of abortions presenting alloimmune abnormalities were compared with 26 normal couples (33). It was found that the percentage of women with alloimmune recurrent spontaneous abortions lacking inhibitory NKRs carried by their husbands and/or having a limited inhibitory KIR repertoire was much higher than that for women with successful pregnancy outcomes, thereby arguing for a role of the inhibitory KIRs in protecting the fetus.…”

Section: Mechanisms Of Fetomaternal Tolerancementioning

confidence: 99%

Maternal Acceptance of the Fetus: True Human Tolerance

Guleria

Sayegh

2007

The Journal of Immunology

206

191

View full text Add to dashboard Cite

Induction and maintenance of immunologic tolerance in humans remains a desirable but elusive goal. Therefore, understanding the physiologic mechanisms of regulation of immune responses is highly clinically relevant for immune-mediated diseases (e.g., autoimmunity and asthma/allergy) and for cell and organ transplantation. Acceptance of the fetus, which expresses paternally inherited alloantigens, by the mother during pregnancy is a unique example of how the immune system reshapes a destructive alloimmune response to a state of tolerance. Understanding the complex mechanisms of fetomaternal tolerance has important implications for developing novel strategies to induce immunologic tolerance in humans in general and for prevention of spontaneous abortion in at-risk populations in particular.

show abstract

“…[25][26][27] NK hücre reseptörlerinin araştırıldığı bir çalışmada, tekrarlayan spontan düşükleri olan kadınlarda inhibitr KIR'lerin kontrollere göre daha az olduğu bulunmuştur. 27 Bu çalışmada, alloimmün düşüklerde daha az sayıda inhibitör KIR olduğu ve bu düşüklerin trofoblastik HLA klas I moleküllerinin uygun inhibitör KIR olmayan uNK hücreleri tarafından tanınmasın-dan kaynaklandığı kanısına varılmıştır. Yan ve ark.nın yaptığı çalışma bu çalışma ile benzer sonuç-lar sunsa da Witt ve ark.nın sonuçları bu sonuçlarla uyum göstermemektedir.…”

Section: Discussionunclassified