Natural Killer Lymphoma/Leukemia: An Uncommon Pediatric Case with Indolent Course

Cataldo, Andrea Di; Bertuna, Gregoria; Mirabile, Elena; Munda, Silvana; Tettoni, K.; Notarangelo, Luigi D.; Facchetti, Fabio; Nigro, Luca Lo

doi:10.1080/10428190410001683714

Cited by 2 publications

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“…Only five cases of T/NK nasal‐type lymphomas were diagnosed in this series. This frequency is somewhat high compared with series in Western countries 10,33,55,56. Unfortunately, information about HTLV‐1 serological status was not usually available in our study.…”

Section: Discussionmentioning

confidence: 59%

Pediatric lymphomas in Brazil

Gualco¹,

Klumb²,

Barber³

et al. 2010

Clinics

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OBJECTIVE:This study provides the clinical pathological characteristics of 1301 cases of pediatric/adolescent lymphomas in patients from different geographic regions of Brazil.METHODS:A retrospective analyses of diagnosed pediatric lymphoma cases in a 10‐year period was performed. We believe that it represents the largest series of pediatric lymphomas presented from Brazil.RESULTS:Non‐Hodgkin lymphomas represented 68% of the cases, including those of precursor (36%) and mature (64%) cell origin. Mature cell lymphomas comprised 81% of the B‐cell phenotype and 19% of the T‐cell phenotype. Hodgkin lymphomas represented 32% of all cases, including 87% of the classical type and 13% of nodular lymphocyte predominant type. The geographic distribution showed 38.4% of the cases in the Southeast region, 28.7% in the Northeast, 16.1% in the South, 8.8% in the North, and 8% in the Central‐west region. The distribution by age groups was 15–18 years old, 33%; 11–14 years old, 26%; 6–10 years old, 24%; and 6 years old or younger, 17%. Among mature B‐cell lymphomas, most of the cases were Burkitt lymphomas (65%), followed by diffuse large B‐cell lymphomas (24%). In the mature T‐cell group, anaplastic large cell lymphoma, ALK‐positive was the most prevalent (57%), followed by peripheral T‐cell lymphoma, then not otherwise specified (25%). In the group of classic Hodgkin lymphomas, the main histological subtype was nodular sclerosis (76%). Nodular lymphocyte predominance occurred more frequently than in other series.CONCLUSION:Some of the results found in this study may reflect the heterogeneous socioeconomical status and environmental factors of the Brazilian population in different regions.

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