Natural killer-like activity induced in spleen by IP injection of BCG

Pioch, Y; Gerber, Mariette; Serrou, B

doi:10.1007/bf00199196

Cited by 7 publications

(1 citation statement)

References 25 publications

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“…Previous studies (Ting et al, 1976a;Glaser et al, 1976) (Pioch et al, 1979) that our system did not possess natural killers against MBL2 target cells, and that when non-Tkiller cells were induced after BCG treatment they were not protective in the Winn assay. Formal proof would require the use of more purified populations (i.e.…”

Section: Significance Of Ctl After Various Immunizing Proceduresmentioning

confidence: 72%

Significance of cytotoxic lymphocytes after various immunizing procedures in a virus-induced non-producer syngeneic system: correlation between in vitro and in vivo lytic activity

Pioch¹,

Gerber²,

Serrou³

1980

Br J Cancer

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An originally virus-induced, non-producer tumour system has been studied in relation to humoral and cellular cytotoxic responses to transplantation and other immunization techniques. In all experimental groups cytotoxic lymphocytes (CTL) were observed either directly or after mixed culture of lymphocytes and tumour cells (MLTC). Except for C'-dependent cytotoxic antibodies in mice immunized by irradiated cells, no antibody-mediated cytotoxicity was observed. In 2 protocols (transplantation and immunization by mitomycin-treated cells) CTL in vitro were not protective. In a third protocol (immunization by irradiated cells) CTL afforded partial protection and other factors appeared to be involved. The best in vivo protection was induced by immunization consequent on early surgical removal of a small number of transplanted tumour cells. This study provides lines of evidence for the effectiveness of protection supplied by CTL in well-defined conditions. Comparison with other modes of immunization indicated that these conditions were related to the quantity and to the characteristics of antigen involved.

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Section: Significance Of Ctl After Various Immunizing Proceduresmentioning

confidence: 72%

Significance of cytotoxic lymphocytes after various immunizing procedures in a virus-induced non-producer syngeneic system: correlation between in vitro and in vivo lytic activity

Pioch¹,

Gerber²,

Serrou³

1980

Br J Cancer

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Natural killer cells induced by acute and chronic toxoplasma infection

Hauser

Sharma

Remington

1982

Cellular Immunology

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The Effect of Tumor Burden on the Modulation of Natural Killer Cell Activity

Morales

Pang

1984

Journal of Urology

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In this study, experiments were conducted to investigate immuno-modulating effects of bacillus Calmette-Guerin and poly I:C as determined by the cytotoxic activity of spleen and peritoneal exudates of C3H/HeN mice against MBT-2 target cells in vitro and the tumor growth patterns in vivo. It was found that animals receiving bacillus Calmette-Guerin exhibited most of the cytotoxic activity in the peritoneal exudate cells. On the contrary, animals receiving poly I:C exhibited most of the NK activity in the splenocytes and little or none in the peritoneal exudate cells. Administration of bacillus Calmette-Guerin or poly I:C in mice bearing small tumors (1 cm. mean diameter) resulted in an increased natural killer cell activity in the exudates and splenocytes of 65 and 50 per cent respectively. No cytotoxic activity was demonstrated when either of the 2 agents was administered to mice bearing large tumors. However, surgical excision of the tumor followed by bacillus Calmette-Guerin or poly I:C administration resulted in levels of natural killer cell activity comparable to those observed in tumor-free animals or in mice bearing tumors of 1 cm. in diameter.

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Natural killer-like activity induced in spleen by IP injection of BCG

Cited by 7 publications

References 25 publications

Significance of cytotoxic lymphocytes after various immunizing procedures in a virus-induced non-producer syngeneic system: correlation between in vitro and in vivo lytic activity

Significance of cytotoxic lymphocytes after various immunizing procedures in a virus-induced non-producer syngeneic system: correlation between in vitro and in vivo lytic activity

Natural killer cells induced by acute and chronic toxoplasma infection

The Effect of Tumor Burden on the Modulation of Natural Killer Cell Activity

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