Natural killer cells in the innate immunity network of atherosclerosis

Bonaccorsi, Irene; Pasquale, Claudia De; Campana, Stefania; Barberi, Chiara; Cavaliere, Riccardo; Benedetto, Filippo; Ferlazzo, Guido

doi:10.1016/j.imlet.2015.09.006

Cited by 29 publications

(20 citation statements)

References 108 publications

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“…CD8 + , γδ and natural killer T‐cells; Bonaccorsi et al. ) and CD4 + regulatory T‐cells. These interact with anti‐inflammatory factors, such as interleukin (IL)‐1 receptor antagonist, transforming growth factor (TGF)‐ β 2 and matrix protease inhibitors like tissue inhibitor of metalloproteinase (TIMP)‐1 (Gupta et al.…”

Section: Vicious Circle Of Dedmentioning

confidence: 99%

Clinical impact of inflammation in dry eye disease: proceedings of the ODISSEY group meeting

Baudouin

İrkeç

Messmer

et al. 2017

Acta Ophthalmologica

126

141

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Dry eye disease (DED) is a common, multifactorial ocular condition with major impact on vision and quality of life. It is now well recognized that the pathophysiology of chronic DED can include a cycle of inflammation involving both innate and adaptive immune responses. Recently, in vitro/in vivo models have been used to obtain a better understanding of DED‐related inflammatory processes at molecular/cellular levels although they do not truly reproduce the complex and chronic hallmarks of human DED. In clinical DED research, advanced techniques such as impression cytology, conjunctival biopsy, in vivo confocal microscopy and multiplex tear analyses have allowed an improved assessment of inflammation in DED patients. This was supported by the identification of reliable inflammatory markers including matrix metalloproteinase‐9, human leucocyte antigen‐DR or intercellular adhesion molecule‐1 in tears and impression cytology samples. One of the current therapeutic strategies focuses on breaking the inflammatory cycle perpetuating the ocular surface disease, and preclinical/clinical research has led to the development of promising anti‐inflammatory compounds. For instance, cyclosporine, already approved in the United States, has recently been authorized in Europe to treat DED associated with severe keratitis. In addition, other agents such as corticosteroids, doxycycline and essential fatty acids, through their anti‐inflammatory properties, show encouraging results. We now have a clearer understanding of the inflammatory processes involved in DED, and there is hope that the still emerging preclinical/clinical findings will be translated into new and highly effective therapies for patients in the near future.

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Section: Vicious Circle Of Dedmentioning

confidence: 99%

Clinical impact of inflammation in dry eye disease: proceedings of the ODISSEY group meeting

Baudouin

İrkeç

Messmer

et al. 2017

Acta Ophthalmologica

126

141

View full text Add to dashboard Cite

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“…NK-released cytokines are able in turn to promote DC maturation, leading to an exacerbation inflammatory response. NK/DC crosstalk might be envisaged as a potential interaction occurring within atherosclerotic lesions, which might worsen disease progression [102] (Figure 5(a)). In fact, the crosstalk between activated dendritic cells/macrophages and NK cells induces IFN- γ release by NK cells that in turn promotes metalloproteinases (MMPs) secretion from cDCs and MΦ.…”

Section: Natural Killer Cells In Atherosclerosismentioning

confidence: 99%

“…In fact, the crosstalk between activated dendritic cells/macrophages and NK cells induces IFN- γ release by NK cells that in turn promotes metalloproteinases (MMPs) secretion from cDCs and MΦ. Activated MΦ produce TNF- α increasing enhance endothelial cell adhesion molecules and MMPs can damage the extracellular matrix leading to atherosclerotic plaque destabilization [102] (Figure 5(a)). …”

Section: Natural Killer Cells In Atherosclerosismentioning

confidence: 99%

Natural Killer Cells in the Orchestration of Chronic Inflammatory Diseases

Parisi

Bassani

Tremolati

et al. 2017

Journal of Immunology Research

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Inflammation, altered immune cell phenotype, and functions are key features shared by diverse chronic diseases, including cardiovascular, neurodegenerative diseases, diabetes, metabolic syndrome, and cancer. Natural killer cells are innate lymphoid cells primarily involved in the immune system response to non-self-components but their plasticity is largely influenced by the pathological microenvironment. Altered NK phenotype and function have been reported in several pathological conditions, basically related to impaired or enhanced toxicity. Here we reviewed and discussed the role of NKs in selected, different, and “distant” chronic diseases, cancer, diabetes, periodontitis, and atherosclerosis, placing NK cells as crucial orchestrator of these pathologic conditions.

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“…Currently, there is a certain consensus that probiotic bacteria can help in the relief of symptoms associated to several human diseases, including some immunopathologies such as atopic diseases and inflammatory bowel diseases (IBD), chronic infections [2], neoplasms and they have even been proposed to play a role in the complex immune network underlying atherogenesis [3,4]. The beneficial effects of probiotics, which are usually administered per os, have been ascribed to different factors: help in the absorption of otherwise indigestible nutrients, especially complex carbohydrates; release of anti-inflammatory soluble factors; production of antimicrobial substances; competition for adhesion, sites and nutrients with pathogenic bacteria; stimulation of the immune system [5].…”

Section: Th17 Skewing In the Galt Of A Crohn Disease Patient Upon Lacmentioning

confidence: 99%

Th17 skewing in the GALT of a Crohn disease patient upon Lactobacillus rhamnosus GG consumption

et al. 2016

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Natural killer cells in the innate immunity network of atherosclerosis

Cited by 29 publications

References 108 publications

Clinical impact of inflammation in dry eye disease: proceedings of the ODISSEY group meeting

Clinical impact of inflammation in dry eye disease: proceedings of the ODISSEY group meeting

Natural Killer Cells in the Orchestration of Chronic Inflammatory Diseases

Th17 skewing in the GALT of a Crohn disease patient upon Lactobacillus rhamnosus GG consumption

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