Natural killer cells in inflammation and autoimmunity

Zitti, Beatrice; Bryceson, Yenan T.

doi:10.1016/j.cytogfr.2018.08.001

Cited by 115 publications

(92 citation statements)

References 124 publications

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“…Among these, NK cells are lymphocytes that mediate multiple effector functions and detect and eliminate transformed or virus-infected cells. However, NK cells reportedly express cell surface TLRs and directly recognize or respond to pathogens [6,10]. TLR expression and function in NK cells were revealed owing to their potential involvement in the innate immune response to bacterial and viral infections via induction of NK cell-mediated cytotoxicity and cytokine production [6,8,11,12].…”

Section: Introductionmentioning

confidence: 99%

Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy

Noh

Yoon

Kim

et al. 2020

Journal of Immunology Research

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Innate immunity represents the first barrier for host defense against microbial infection. Toll-like receptors (TLRs) are the most well-defined PRRs with respect to PAMP recognition and induction of innate immune responses. They recognize pathogen-associated molecular patterns (PAMPs) and trigger innate immune responses by inducing inflammatory cytokines, chemokines, antigen-presenting molecules, and costimulatory molecules. TLRs are expressed either on the cell surface or within endosomes of innate immune cells. NK cells are one of the innate immune cells and also express TLRs to recognize or respond to PAMPs. TLRs in NK cells induce the innate immune responses against bacterial and viral infections via inducing NK cytotoxicity and cytokine production. In this review, we will discuss the expression and cellular function of TLRs in NK cells and also introduce some therapeutic applications of TLR agonists for NK cell-mediated immunotherapy.

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Section: Introductionmentioning

confidence: 99%

Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy

Noh

Yoon

Kim

et al. 2020

Journal of Immunology Research

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“…Natural Killer (NK) cells are important effector cells of the innate immune system. They comprise about 10-15% of the mononuclear cells in the peripheral blood [1][2][3]. Phenotypically, they are non-T and non-B lymphocytes and express CD16 (FcγRIIIa; the low-affinity receptor for the Fc region of IgG) and CD56 (an isoform of the Neural Cell Adhesion Molecule (N-CAM)) on their surface.…”

Section: Introductionmentioning

confidence: 99%

Phenotypic and Functional Changes in Peripheral Blood Natural Killer Cells in Crohn Disease Patients

Samarani

Sagala

Jantchou

et al. 2020

Mediators of Inflammation

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We investigated activation status, cytotoxic potential, and gut homing ability of the peripheral blood Natural Killer (NK) cells in Crohn disease (CD) patients. For this purpose, we compared the expression of different activating and inhibitory receptors (KIR and non-KIR) and integrins on NK cells as well as their recent degranulation history between the patients and age-matched healthy controls. The study was conducted using freshly obtained peripheral blood samples from the study participants. Multiple color flow cytometry was used for these determinations. Our results show that NK cells from treatment-naïve CD patients expressed higher levels of activating KIR as well as other non-KIR activating receptors vis-à-vis healthy controls. They also showed increased frequencies of the cells expressing these receptors. The expression of several KIR and non-KIR inhibitory receptors tended to decrease compared with the cells from healthy donors. NK cells from the patients also expressed increased levels of different gut-homing integrin molecules and showed a history of increased recent degranulation events both constitutively and in response to their in vitro stimulation. Furthermore, treatment of the patients tended to reverse these NK cell changes. Our results demonstrate unequivocally, for the first time, that peripheral blood NK cells in treatment-naïve CD patients are more activated and are more poised to migrate to the gut compared to their counterpart cells from healthy individuals. Moreover, they show that treatment of the patients tends to normalize their NK cells. The results suggest that NK cells are very likely to play a role in the immunopathogenesis of Crohn disease.

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“…In contrast to mammals, tissues, such as spleen, blood, or lung, of chickens contain a very low frequency of NK cells (ranging from 0.5% to 1%), being mainly confined in the intestinal epithelium [90]. These cells not only have the ability to kill infected or malignant cells, but also mediate cytotoxicity on several types of activated immune cells, playing a key role in the control of immune responses and maintenance of homeostasis [91]. A therapeutic effect of Lactobacillus plantarum has been detected in vitro on NK cells.…”

Section: Effects Of Probiotics On Cells Of the Innate Immune Systemmentioning

confidence: 99%

The Control of Intestinal Inflammation: A Major Objective in the Research of Probiotic Strains as Alternatives to Antibiotic Growth Promoters in Poultry

et al. 2020

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The reduction of antimicrobial resistance is a major challenge for the scientific community. In a few decades, infections by resistant bacteria are forecasted to be the main cause of death in the world. The withdrawal of antibiotics as growth promoters and their preventive use in animal production is essential to avoid these resistances, but this may impair productivity and health due to the increase in gut inflammation. This reduction in productivity aggravates the problem of increasing meat demand in developing countries and limits the availability of raw materials. Probiotics are promising products to address this challenge due to their beneficial effects on microbiota composition, mucosal barrier integrity, and immune system to control inflammation. Although many modes of action have been demonstrated, the scientific community is not able to describe the specific effects that a probiotic should induce on the host to maximize both productivity and animal health. First, it may be necessary to define what are the innate immune pathways acting in the gut that optimize productivity and health and to then investigate which probiotic strain is able to induce the specific effect needed. This review describes several gaps in the knowledge of host-microbiota-pathogen interaction and the related mechanisms involved in the inflammatory response not demonstrated yet in poultry.

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Natural killer cells in inflammation and autoimmunity

Cited by 115 publications

References 124 publications

Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy

Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy

Phenotypic and Functional Changes in Peripheral Blood Natural Killer Cells in Crohn Disease Patients

The Control of Intestinal Inflammation: A Major Objective in the Research of Probiotic Strains as Alternatives to Antibiotic Growth Promoters in Poultry

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