Natural killer cells in experimental and human leishmaniasis

Bogdan, Christian

doi:10.3389/fcimb.2012.00069

Cited by 59 publications

(50 citation statements)

References 109 publications

(152 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…With respect to TNF‐α and IFN‐γ, Group I patients expressed more than those from Group II. These data suggest that the presence of these two cytokines and CD57 in the early period of infection can be correlated with the control of parasites as previously described in other studies . IFN‐γ synergistically linked to TNF‐α activate macrophages to induce the nitric oxide synthase that leads to death of intracellular parasites .…”

Section: Discussionsupporting

confidence: 81%

American cutaneous leishmaniasis: In situ immune response of patients with recent and late lesions

Gomes

Martines

Kanamura

et al. 2017

Parasite Immunology

View full text Add to dashboard Cite

TNF-α, IFN-γ, IL-10, IL-17, CD68 and CD57 were evaluated in biopsies of patients with American cutaneous leishmaniasis living in Sorocaba, Brazil. The analyses were performed considering the time of lesions from 23 patients with recent lesions (Group I) and 19 patients with late lesions (Group II). All patients were infected with Leishmania (Viannia) braziliensis. Immunostaining cells for CD68, CD57, TNF- α, IFN-γ, IL-10 and IL-17 were performed by immunohistochemistry. Except for CD68 and IL-17, the distribution of in situ for CD57, IL-10, TNF-α and IFN-γ showed that patients with recent lesions expressed higher levels than those with late lesions. The comparison of cytokine expression/group showed that IL-10 was significantly higher than IL-17 and IFN-γ (similar data were shown in IL-17 compared with TNF-α), suggesting an immunological balance between inflammatory-anti-inflammatory agents. This balance was similar for two groups of patients. In conclusion, these data suggested that (i) patients from Group I had recent lesions (in the beginning of chronic phase) compared to those from Group II and (ii) the modulation of inflammatory response in patients with recent American cutaneous leishmaniasis was correlated with IL-10 expression in skin lesions preventing the development of mucosal forms. The parasite treatment also prevented the evolution of severe forms.

show abstract

Section: Discussionsupporting

confidence: 81%

American cutaneous leishmaniasis: In situ immune response of patients with recent and late lesions

Gomes

Martines

Kanamura

et al. 2017

Parasite Immunology

View full text Add to dashboard Cite

show abstract

“…It is likely that other cells contribute to IL-10-mediated immune regulation during progressive human VL. Follicular dendritic cells (DCs) (45), natural killer cells (NK) (46), or T follicular helper cells (45, 47) were shown to be immune regulators of VL. IgD hi regulatory B cells may be an early inducer of additional regulatory cell populations.…”

Section: Discussionmentioning

confidence: 99%

Regulatory IgDhi B Cells Suppress T Cell Function via IL-10 and PD-L1 during Progressive Visceral Leishmaniasis

Schaut

Lamb

Toepp

et al. 2016

The Journal of Immunology

View full text Add to dashboard Cite

During visceral leishmaniasis (VL), T helper 1 (Th1)-based inflammation is induced to control intracellular parasites. Inflammation-based pathology has been shown to be dampened by interleukin 10 and eventual Programmed Death1 (PD1)-mediated T cell exhaustion. Cell type(s) responsible for the initiation of T cell-produced IL-10 during VL are unknown. CD19+, CD5−, CD1d−, IgDhi regulatory B cells from healthy controls produced IL-10 in absence of infection or stimulation in contrast to IgDlo/neg B cells. IgDhi B cells may have a de novo vs. induced regulatory program. IgDhi B cells increased three-fold in population size as VL progressed. B cells from VL dogs were necessary and sufficient to suppress T helper 1 (Th1) cell effector function. IgDhi B cells induced T cell and IgDlo B cell IL-10 production. Blockage of B cell-specific PD-L1 restored Th1 responses. IgDhi regulatory B cells represent a novel regulatory B cell which may precipitate T cell exhaustion during VL.

show abstract

“…3), which suggested a generalized defect in T cell activation. The low NK cell numbers fluctuating with disease activity could be explained as a reaction to leishmaniasis (27). The clinical observation that the patient only suffered from relapses of visceral leishmaniasis, but did not develop persistent or recurrent infections with other pathogens, might indicate impairment of his immunosurveillance against only certain intracellular microbes.…”

Section: Discussionmentioning

confidence: 95%

A Novel Thymoma-Associated Immunodeficiency with Increased Naive T Cells and Reduced CD247 Expression

Christopoulos

Dopfer

Malkovsky

et al. 2015

The Journal of Immunology

Self Cite

View full text Add to dashboard Cite

The mechanisms underlying thymoma-associated immunodeficiency are largely unknown, and the significance of increased blood γδ Τ cells often remains elusive. In this study we address these questions based on an index patient with thymoma, chronic visceral leishmaniasis, myasthenia gravis, and a marked increase of rare γδ T cell subsets in the peripheral blood. This patient showed cutaneous anergy, even though he had normal numbers of peripheral blood total lymphocytes as well as CD4+ and CD8+ T cells. Despite his chronic infection, analyses of immunophenotypes and spectratyping of his lymphocytes revealed an unusual accumulation of naive γδ and αβ T cells, suggesting a generalized T cell activation defect. Functional studies in vitro demonstrated substantially diminished IL-2 and IFN-γ production following TCR stimulation of his “untouched” naive CD4+ T cells. Biochemical analysis revealed that his γδ and αβ T cells carried an altered TCR complex with reduced amounts of the ζ-chain (CD247). No mutations were found in the CD247 gene that encodes the homodimeric ζ protein. The diminished presence of CD247 and increased numbers of γδ T cells were also observed in thymocyte populations obtained from three other thymoma patients. Thus, our findings describe a novel type of a clinically relevant acquired T cell immunodeficiency in thymoma patients that is distinct from Good’s syndrome. Its characteristics are an accumulation of CD247-deficient, hyporresponsive naive γδ and αβ T cells and an increased susceptibility to infections.

show abstract

Natural killer cells in experimental and human leishmaniasis

Cited by 59 publications

References 109 publications

American cutaneous leishmaniasis: In situ immune response of patients with recent and late lesions

American cutaneous leishmaniasis: In situ immune response of patients with recent and late lesions

Regulatory IgDhi B Cells Suppress T Cell Function via IL-10 and PD-L1 during Progressive Visceral Leishmaniasis

A Novel Thymoma-Associated Immunodeficiency with Increased Naive T Cells and Reduced CD247 Expression

Contact Info

Product

Resources

About